Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor

Wang, Shige; Li, Kai; Chen, Yu; Chen, Hangrong; Ma, Ming; Jiang, Feng; Zhao, Qinghua; Shi, Jianlin

doi:10.1016/j.biomaterials.2014.11.009

Cited by 298 publications

(244 citation statements)

References 56 publications

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“…On the other hand, in our previous reports about the use of polyethylene glycol (PEG) functionalized TMDCs for in vivo imaging and therapy applications, we have uncovered that PEGylated MoS 2 and WS 2 showed no appreciable acute toxicity to the treated mice at our tested dose 16, 20, 23, 34. Similar findings have also been reported by several other groups regarding the in vivo toxicity of TMDCs with biocompatible surface coatings 21, 30, 35. However, the detailed in vivo long‐term degradation and excretion behaviors of various TMDCs remain to be investigated to our best knowledge.…”

Section: Introductionsupporting

confidence: 90%

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In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

et al. 2016

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With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of different TMDCs, and hopefully to identify the most promising type of TMDCs with low toxicity and fast excretion for further biomedical applications. Herein, the in vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS2), tungsten dichalcogenides (WS2), and titanium dichalcogenides (TiS2) nanosheets are systematically investigated. Without showing significant in vitro cytotoxicity, all the three types of polyethylene glycol (PEG) functionalized TMDCs show dominate accumulation in reticuloendothelial systems (RES) such as liver and spleen after intravenous injection. In marked contrast to WS2‐PEG and TiS2‐PEG, which show high levels in the organs for months, MoS2‐PEG can be degraded and then excreted almost completely within one month. Further degradation experiments indicate that the distinctive in vivo excretion behaviors of TDMCs can be attributed to their different chemical properties. This work suggests that MoS2, among various TMDCs, may be particularly interesting for further biomedical applications owning to its low toxicity, capability of biodegradation, and rapid excretion.

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Section: Introductionsupporting

confidence: 90%

“…In the past few years, there have been a number of reports studying the toxicity of TMDCs nanomaterials in vitro and in vivo 27, 28, 29, 30, 31. At the in vitro level, it was found that the cytotoxicity of MoS 2 , WS 2 , and WSe 2 nanosheets appeared to be low to different cell lines 15, 18, 32, 33.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

et al. 2016

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“…In addition, previous studies have demonstrated that MoS 2 nanosheets possessed excellent photothermal therapeutic effects on tumors both in vitro and in vivo. [15][16][17][18] However, these studies primarily focused on simple tumor therapy using MoS 2 in the form of particles, which limits their application. Specifically, MoS 2 particles lack the desired mechanical strength and porous structure to induce bone regeneration after the surgical resection of tumor tissues and repair large tumor-induced bone defects.…”

Section: Introductionmentioning

confidence: 99%

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Wang

et al. 2017

NPG Asia Mater

126

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The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS 2 nanosheets were grown in situ on the strut surface of bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS 2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials.

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“…Due to the fascinating physicochemical and electronic properties arising from the small dimensions and quantum confinement effects (QCE) [1][2][3], ultrathin nanosheets have been the focus of substantial research in the light of fundamental studies and their broad applications in various fields, including optoelectronic devices [4], energy conversion and storage [5], sensors [6][7][8][9], biomedicine [10], and catalysis [11][12][13][14][15]. In particular, polymeric graphitic carbon nitride nanosheets (GCNNs), an n-type semiconductor, have been receiving considerable attention due to their many intriguing advantages such as the fact that they contain no metal, and nontoxicity, easy availability, sensitive photo-response, excellent chemical and thermal stability, and unique electronic structures [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Reduced-sized monolayer carbon nitride nanosheets for highly improved photoresponse for cell imaging and photocatalysis

Liang

Bai

et al. 2016

Sci. China Mater.

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Two-dimensional graphitic carbon nitride (g-C3N4) nanosheets (GCNNs) have been considered as an attractive metal-free semiconductor because of their superior catalytic, optical, and electronic properties. However, it is still challenging to prepare monolayer GCNNs with a reduced lateral size in nanoscale. Herein, a highly efficient ultrasonic technique was used to prepare nanosized monolayer graphitic carbon nitride nanosheets (NMGCNs) with a thickness of around 0.6 nm and an average lateral size of about 55 nm. With a reduced lateral size yet monolayer thickness, NMGCNs show unique photo-responsive properties as compared to both large-sized GCNNs and GCN quantum dots. A dispersion of NMGCNs in water has good stability and exhibits strong blue fluorescence with a high quantum yield of 32%, showing good biocompatibility for cell imaging. Besides, compared to the multilayer GCNNs, NMGCNs show a highly improved photocatalysis under visible light irradiation. Overall, NMGCNs, characterized with monolayer and nanosized lateral dimension, fill the gap between large size (very high aspect ratio) and quantum dot-like counterparts, and show great potential applications as sensors, photo-related and electronic devices.

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Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor

Cited by 298 publications

References 56 publications

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Reduced-sized monolayer carbon nitride nanosheets for highly improved photoresponse for cell imaging and photocatalysis

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Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor

Cited by 298 publications

References 56 publications

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Reduced-sized monolayer carbon nitride nanosheets for highly improved photoresponse for cell imaging and photocatalysis

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Product

Resources

About

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets