Biocompatible packagings for fully implantable multi-panel devices for remote monitoring of metabolism

Baj-Rossi, Camilla; Cavallini, Alberto; Jost, Tanja Rezzonico; Proietti, Michele; Grassi, Fabio; Micheli, Giovanni De; Carrara, Sandro

doi:10.1109/biocas.2015.7348398

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Following the authors conclusion, the results stress the importance of (1) miniaturization of the biosensors, “the smaller the better” as well as (2) a need for bioactive, immune-suppressive coatings for long-time body acceptance of the foreign elements. Other coating materials could be silicone or polyurethane . Furthermore, investigations focus on different materials and techniques used as biofluid barriers of implantable devices or biodegradable silicon-based encapsulation layers and electrical interfaces, e.g., for temporary in vivo sensors, biodegradable conducting inks, or degradable supercapacitors for energy storage …”

Section: Sensor Solutions For Point-of-care and In Vivo Detectionmentioning

confidence: 99%

A Megatrend Challenging Analytical Chemistry: Biosensor and Chemosensor Concepts Ready for the Internet of Things

2019

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The Internet of Things (IoT) is a megatrend that cuts across all scientific and engineering disciplines and establishes an integrating technical evolution to improve production efficiencies and daily human life. Linked machines and sensors use decision-making routines to work toward a common product or solution. Expanding this technical revolution into the value chain of complex areas such as agriculture, food production, and healthcare requires the implementation and connection of sophisticated (bio)analytical methods. Today, wearable sensors, monitors, and point-of-care diagnostic tests are part of our daily lives and improve patients’ medical progression or athletes’ monitoring capabilities that are already beyond imagination. Also, early contributions toward sensor networks and finally the IT revolution with wireless data collection and transmission via Bluetooth or smartphones have set the foundation to connect remote sensors and distributed analytical chemical services with centralized laboratories, cloud storage, and cloud computing. Here, we critically review those biosensor and chemosensor technologies and concepts used in an IoT setting or considered IoT-ready that were published in the period 2013–2018, while also pointing to those foundational concepts and ideas that arose over the last two decades. We focus on these sensors due to their unique ability to be remotely stationed and that easily function in networks and have made the greatest progress toward IoT integration. Finally, we highlight requirements and existing and future challenges and provide possible solutions important toward the vision of a seamless integration into a global analytical concept, which includes many more analytical techniques than sensors and includes foremost next-generation sequencing and separation principles coupled with MS detection.

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Section: Sensor Solutions For Point-of-care and In Vivo Detectionmentioning

confidence: 99%

A Megatrend Challenging Analytical Chemistry: Biosensor and Chemosensor Concepts Ready for the Internet of Things

2019

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“…Failing in these aspects may cause serious injuries to the patients that can even be fatal. [49][50][51][52][53][54]…”

Section: End Notementioning

confidence: 99%

Pharmacoelectronics and Electropharmaceutics: The Arts and Science of Electronic Drug Delivery

Narayanan¹,

Charyulu²

2017

Rese. Jour. of Pharm. and Technol.

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Electronics is deemed to have tremendous scope in the improvement of diagnostic and drug delivery devices. Miniaturization of microprocessors, along with development of biocompatible semiconductor materials can offer breakthrough in drug therapy tomorrow. Controlled drug delivery systems based on polymeric materials have captured the market replacing the conventional formulations. The author discuss the current development in the field of bioelectronics towards electronic drug delivery systems (EDDS) proposing the emergence of new subject specialties in the field of electronics and pharmaceutics that may be termed as 'pharmacoelectronics' and 'electro pharmaceutics'. Many technological advancements like Actipatch TM , Intellicap®, Smart bandages etc are discussed. The basic electronic components incorporated in an electronic drug delivery device may be the drug reservoir, a power source, pumping system, microcontroller, various sensors for ambient temperature, pH, osmotic pressure, light, ion concentrations etc. The study of basic electronics and these electronic components may be an integral part of training for a future pharmaceutical formulation scientist.

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Uncovering the Diversification of Tissue Engineering on the Emergent Areas of Stem Cells, Nanotechnology and Biomaterials

Dubey

Alexander

Munnangi

et al. 2020

CSCR

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Damaged or disabled tissue is life-threatening due to the lack of proper treatment. Many conventional transplantation methods like autograft, iso-graft and allograft are in existence for ages, but they are not sufficient to treat all types of tissue or organ damages. Stem cells, with their unique capabilities like self-renewal and differentiate into various cell types, can be a potential strategy for tissue regeneration. However, the challenges like reproducibility, uncontrolled propagation and differentiation, isolation of specific kinds of cell and tumorigenic nature made these stem cells away from clinical application. Today, various types of stem cells like embryonic, fetal or gestational tissue, mesenchymal and induced-pluripotent stem cells are under investigation for their clinical application. Tissue engineering helps in configuring the stem cells to develop into a desired viable tissue, to use them clinically as a substitute for the conventional method. The use of stem cell-derived Extracellular Vesicles (EVs) is being studied to replace the stem cells, which decreases the immunological complications associated with the direct administration of stem cells. Tissue engineering also investigates various biomaterials to use clinically, either to replace the bones or as a scaffold to support the growth of stemcells/ tissue. Depending upon the need, there are various biomaterials like bio-ceramics, natural and synthetic biodegradable polymers to support replacement or regeneration of tissue. Like the other fields of science, tissue engineering is also incorporating the nanotechnology to develop nano-scaffolds to provide and support the growth of stem cells with an environment mimicking the Extracellular matrix (ECM) of the desired tissue. Tissue engineering is also used in the modulation of the immune system by using patient-specific Mesenchymal Stem Cells (MSCs) and by modifying the physical features of scaffolds that may provoke the immune system. This review describes the use of various stem cells, biomaterials and the impact of nanotechnology in regenerative medicine.

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Biocompatible packagings for fully implantable multi-panel devices for remote monitoring of metabolism

Cited by 3 publications

References 13 publications

A Megatrend Challenging Analytical Chemistry: Biosensor and Chemosensor Concepts Ready for the Internet of Things

A Megatrend Challenging Analytical Chemistry: Biosensor and Chemosensor Concepts Ready for the Internet of Things

Pharmacoelectronics and Electropharmaceutics: The Arts and Science of Electronic Drug Delivery

Uncovering the Diversification of Tissue Engineering on the Emergent Areas of Stem Cells, Nanotechnology and Biomaterials

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