Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

Qi, Lei; Pan, Tonghe; Ou, Liling; Ye, Zhiqiang; Yu, Chunlei; Bao, Bijun; Wu, Zixia; Cao, Dengqing; Dai, Liming

doi:10.1038/s42003-021-01713-1

Cited by 61 publications

(46 citation statements)

References 43 publications

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“…TAT peptides (TAT-NGs) that target the nucleus were incorporated to aminefunctionalized GQDs, which were subsequently grafted with cancer-cell-targeting folic acid (FA) modified PEG through disulfide linkage (FAPEG-TNGs). The resulting FAPEG-TNGs demonstrated excellent biocompatibility, nucleus uptake, and cancer cell targeting abilities (Qi et al, 2021).…”

Section: Graphene Qdsmentioning

confidence: 99%

Quantum Dots: An Emerging Approach for Cancer Therapy

Devi¹,

Kumar

Tiwari

et al. 2022

Front. Mater.

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Nanotechnology is indisputably a scientific technique that offers the prospect of new therapies, and hope, for the treatment of malignant illnesses. It is a novel technology that offers new approaches for the diagnosis and management of diverse diseases. Although the discovery of Quantum dots (QD) nano-transporters has already led to a few positive developments, QD nano-transporters are still at their initial stage, though have yet proven valuable to society. The excertion of QD indicates conversion in natural imaging along with photograph have established incredible suitability in bio-imaging, new drug development, targeted gene deliverance, biosensing, photodynamic treatment as well as diagnosis. The present review aimed to confer the significance of QD in diagnosis as well as in management of cancer. This review aims to impart fundamental insight as well as conception of QD its merits, properties, utilization as well as mode of action. This review highlight of different designing schemes of QD like hydrothermal, drop-casting, ultrasonic, solvothermal, spin-coating, atomic layer desorption, layer by layer, polymethylmethacrylate aided-transfer, electrochemical, ion beam sputtering deposition. Moreover, we have elaborated on the diverse researches related to cytotoxic examination to reveal that QDs are harmless. Concisely, the present review summarizes the fabrication schemes, current research and utilization of QD in cancer treatment.

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Section: Graphene Qdsmentioning

confidence: 99%

Quantum Dots: An Emerging Approach for Cancer Therapy

Devi¹,

Kumar

Tiwari

et al. 2022

Front. Mater.

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“…As anticancer antibodies are quite expensive, many researchers investigated alternative ligand-based QDs including folic acid (FA), epidermal growth factors, transferrin, and a few aptamers to target cancer cells. For instance, Qi et al developed GQDs that suppress the growth of the tumor by selectively damaging the DNA of the cancer cells (42). The nucleustargeting TAT peptides (TAT-NGs) were added to the aminefunctionalized GQDs, which were then grafted with cancer-celltargeting FA modified PEG via disulfide linkage (FAPEG-TNGs).…”

Section: Qds For In Vitro Diagnosis and Imagingmentioning

confidence: 99%

Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging

et al. 2021

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Ultrasound, computed tomography, magnetic resonance, and gamma scintigraphy-based detection and bio-imaging technologies have achieved outstanding breakthroughs in recent years. However, these technologies still encounter several limitations such as insufficient sensitivity, specificity and security that limit their applications in cancer detection and bio-imaging. The semiconductor quantum dots (QDs) are a kind of newly developed fluorescent nanoparticles that have superior fluorescence intensity, strong resistance to photo-bleaching, size-tunable light emission and could produce multiple fluorescent colors under single-source excitation. Furthermore, QDs have optimal surface to link with multiple targets such as antibodies, peptides, and several other small molecules. Thus, QDs might serve as potential, more sensitive and specific methods of detection than conventional methods applied in cancer molecular targeting and bio-imaging. However, many challenges such as cytotoxicity and nonspecific uptake still exist limiting their wider applications. In the present review, we aim to summarize the current applications and challenges of QDs in cancer research mainly focusing on tumor detection, bio-imaging, and provides opinions on how to address these challenges.

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“…Functionalization of GMs with cancer‐cell‐targeting molecules, for instance, folic acid, [ 94 ] peptide nucleic acids, [ 95 ] DNA [ 96 ] has been widely applied for GMs‐based selective cancer treatment. Meanwhile, inspired by the ability of GMs to activate transport pathways via interaction with membrane proteins (e.g.…”

Section: Interaction Between Membrane Proteins and Gmsmentioning

confidence: 99%

Interactions Between Graphene‐Based Materials and Biological Surfaces: A Review of Underlying Molecular Mechanisms

Chen

Pandit

Rahimi

et al. 2021

Adv Materials Inter

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Understanding the underlying molecular mechanism of how graphene materials (GMs) interact with biological surfaces is the key to develop safe and effective biomedical applications of GMs. Here, a systematic and comprehensive mechanistic perspective of interactions between pristine GMs and biological membranes is provided. To this end, first the known mechanisms of interaction between GMs and membrane components are summarized and classified, with a focus on phospholipids, cholesterol, and membrane proteins. Both experimental observations and computational simulations are included. Detailed experimental conditions and physiochemical properties of GMs are listed for each cited application. At the end of this review, current challenges and conflicts that limit biomedical applications of GMs are discussed. Based on reported mechanisms, guidelines for future studies to address the remaining challenges are proposed, specifically with respect to modulating the intrinsic properties of GMs for more efficient and safer therapeutic applications.

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Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

Cited by 61 publications

References 43 publications

Quantum Dots: An Emerging Approach for Cancer Therapy

Quantum Dots: An Emerging Approach for Cancer Therapy

Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging

Interactions Between Graphene‐Based Materials and Biological Surfaces: A Review of Underlying Molecular Mechanisms

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