Biocompatible nanocarriers an emerging platform for augmenting the antiviral attributes of bioactive polyphenols: A review

Mansi, Kumari; Kumar, Raj; Jindal, Neha; Singh, Kulvinder

doi:10.1016/j.jddst.2023.104269

Cited by 5 publications

(3 citation statements)

References 176 publications

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“…2,6 Aromatic Turmerone (Tur), one of the key components found in turmeric and its essential oil, has garnered attention for its varied therapeutic properties, encompassing anti-oxidant, anti-tumor and anti-cancer activities. [7][8][9][10] The therapeutic potential of Tur extends to the realm of dermatology, particularly in the management of inflammatory skin conditions. Notably, topical applications of Tur have demonstrated efficacy in alleviating skin inflammation in murine models by modulating the expression of key cytokines, presenting itself as a promising candidate for treating inflammatory skin diseases such as psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

Aydin,

Sagiroglu,

Ozturk Civelek

et al. 2024

IJN

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Background: Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in its rhizome. These compounds exhibit diverse therapeutic properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, the topical application of these compounds has a significant potential for inducing skin irritation. This study focuses on formulating solid lipid nanoparticle (SLN) carriers encapsulating both Cur and Tur for reduced irritation and enhanced stability. Methods: SLN formulations were prepared by a method using homogenization followed by ultrasonication procedures and optimized by applying response surface methodology (RSM). Results:The optimized SLN formulation demonstrated entrapment efficiencies, with 77.21 ± 4.28% for Cur and 75.12 ± 2.51% for Tur. A size distribution of 292.11 ± 9.43 nm was obtained, which was confirmed to be a spherical and uniform shape via environmental scanning electron microscopy (ESEM) images. The in vitro release study indicated cumulative releases of 71.32 ± 3.73% for Cur and 67.23 ± 1.64% for Tur after 24 hours under sink conditions. Physical stability tests confirmed the stability of formulation, allowing storage at 4°C for a minimum of 60 days. Notably, in vitro skin irritation studies, utilizing the reconstructed human epidermal model (EPI-200-SIT), revealed a significant reduction in irritation with the SLN containing Cur and Tur compared to nonencapsulated Cur and Tur. Conclusion: These findings collectively endorse the optimized SLN formulation as a favorable delivery system for Cur and Tur in diverse topical uses, offering enhanced stability, controlled release and reduced irritation.

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Section: Introductionmentioning

confidence: 99%

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

Aydin,

Sagiroglu,

Ozturk Civelek

et al. 2024

IJN

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“…They are utilized to treat viral infections by inhibiting viral replication in host cells. [15] The significance of antivirals lies in their ability to reduce the severity and duration of viral infections and prevent their spread to others. [16,17] It is essential to note, however, that not all viral infections can be treated with antivirals, and their efficacy may vary depending on the specific virus and infection stage.…”

Section: Introductionmentioning

confidence: 99%

“…Antivirals are crucial for the treatment of high‐risk patients, such as those with compromised immune systems or chronic medical conditions, who may be more susceptible to severe viral infection complications. They are utilized to treat viral infections by inhibiting viral replication in host cells [15] . The significance of antivirals lies in their ability to reduce the severity and duration of viral infections and prevent their spread to others [16,17] .…”

Section: Introductionmentioning

confidence: 99%

In Silico Antiviral Drug Repurposing Against COVID‐19 Infection: Targeting the Main Protease and Human ACE2 Receptor

Rupavarshini,

Karthikeyan

2023

ChemistrySelect

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Coronavirus Disease‐2019 (COVID‐19) is a highly contagious respiratory illness caused by a novel coronavirus known as SARS‐CoV‐2. The virus exerts its pathogenic activity and infects new cells by utilizing the spike protein (S1) of the coronavirus and the Angiotensin‐converting enzyme 2 (ACE2) receptor protein found in host cells, thereby transferring the genetic material. The SARS‐CoV‐2 main protease, essential for viral replication, presents a promising therapeutic target due to its structural and sequence similarity with other beta coronaviruses, facilitating drug development from existing lead compounds. With this context, we have considered SARS‐CoV‐2 Main protease and spike protein combined with ACE2 receptor as the target protein for inhibiting the replication. In this study, we employed High‐Throughput Virtual Screening (HTVS) to screen antiviral compounds from the drug bank. Based on the docking score, two compounds were screened with respect to the selected target proteins. Subsequently, Molecular docking investigations were conducted for compound A and compound B concerning the main protease and ACE2 receptor, which yields favorable docking scores of −8.212 kcal/mol and −9.373 kcal/mol, respectively. Further molecular dynamics, DFT studies and ADMET parameters were carried out to understand the stability, reactivity, and toxicity profile of the screened compounds.

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Surfactants produced from carbohydrate derivatives: Part 2. A review on the value chain, synthesis, and the potential role of artificial intelligence within the biorefinery concept

Marquez,

Ortiz,

Barrios

et al. 2024

J Surfact & Detergents

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This comprehensive and critical review explores the synthesis and applications of carbohydrate‐based surfactants within the biorefinery concept, focusing on biobased sugar‐head molecules suitable for use across several manufacturing sectors, including cosmetics, pharmaceuticals, household products, detergents, and foods. The main focus relies on sustainable alternatives to conventional surfactants, which could reduce the final manufacturing carbon footprint of several industrial feedstocks and products. A thorough analysis of raw materials, highlighting the significance of feedstock sources, and the current biobased surfactants and rhamnolipid biosurfactants production trends, is presented. Key organic reactions for the production of sorbitan esters, sucrose esters, alkyl polyglycosides, and fatty acid glucamines, such as glycosidation, acylation, and etherification, as well as the production of rhamnolipids through fermentation are described. Given the scarce literature on the characterization of these surfactant types within the hydrophilic–lipophilic deviation (HLD) framework, the surfactant contribution parameter (SCP) in the HLD equation for sugar‐head surfactants is critically assessed. The economic landscape is also discussed, noting the significant growth in the biobased surfactants and biosurfactant market, driven by environmental awareness and regulatory changes, with projections indicating a substantial market increase in the forthcoming years. Finally, the promising potential of generative artificial intelligence (AI) in developing customized surfactant molecules, with optimized properties for targeted applications, is emphasized as a promising avenue for future research.

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Biocompatible nanocarriers an emerging platform for augmenting the antiviral attributes of bioactive polyphenols: A review

Cited by 5 publications

References 176 publications

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

In Silico Antiviral Drug Repurposing Against COVID‐19 Infection: Targeting the Main Protease and Human ACE2 Receptor

Surfactants produced from carbohydrate derivatives: Part 2. A review on the value chain, synthesis, and the potential role of artificial intelligence within the biorefinery concept

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