Biocompatible metal–organic frameworks for the storage and therapeutic delivery of hydrogen sulfide

Chen, Faith E.; Mandel, Ruth M.; Woods, Joshua J.; Lee, Jung‐Hoon; Kim, Jaehwan; Hsu, Jesse H.; Fuentes-Rivera, José J.; Wilson, Justin J.; Milner, Phillip J.

doi:10.1039/d1sc00691f

Cited by 23 publications

(13 citation statements)

References 67 publications

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“…On this ground, H 2 S‐releasing agents (also named H 2 S donors) seem to be adequate for either mimicking the endogenous H 2 S generation under physiological conditions, or replenishing additional H 2 S for both diagnostic and therapeutical purposes. During the past years, substantial endeavor has been made to develop various H 2 S donors, and a number of H 2 S donors with different releasing rates and mechanisms have been reported 101,105–125 . H 2 S donors, regarded as the exogenous suppliers of H 2 S, could be employed as the ideal candidates for the treatment of diseases whose H 2 S‐associated networks might be short‐circuited.…”

Section: Introductionmentioning

confidence: 99%

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song

Zhao

et al. 2022

Medicinal Research Reviews

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Section: Introductionmentioning

confidence: 99%

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song

Zhao

et al. 2022

Medicinal Research Reviews

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“…28 Like other Zrbased MOFs, the strong Zr-O bonds in this framework lend it remarkable chemical stability towards ambient air, water, and corrosive gases. 24,29 In addition, Zr-fum possesses a high density of accessible alkene sites for potential dichlorination. Combined with its scalable synthesis from inexpensive, easily accessible materials, these properties make Zr-fum a promising candidate for irreversible Cl2 capture.…”

Section: Resultsmentioning

confidence: 99%

“…Among MOFs, those assembled from Zr(IV) secondary building units (SBUs), known as Zr-MOFs, demonstrate a high degree of chemical robustness, including towards corrosive gases. [22][23][24][25][26] Indeed, bromination and iodination of alkenes within Zr-and analogous Hf-based MOFs have been previously demonstrated, 15,16,27 supporting the feasibility of halogen capture in alkene-containing MOFs. However, given the significantly higher reactivity of Cl2 compared to Br2 and iodine (I2), prior to our work it remained unclear whether MOFs could undergo linker dichlorination without complete framework degradation.…”

Section: Introductionmentioning

confidence: 86%

Reactive Chlorine Capture by Dichlorination of Alkene Linkers in Metal–Organic Frameworks

Azbell

Mandel

Lee

et al. 2022

Preprint

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Chlorine (Cl2) is a toxic and corrosive gas that is both an essential reagent in industry and a potent chemical warfare agent. Materials that can strongly bind Cl2 at low pressures are essential for industrial and civilian personal protective equipment (PPE). Herein, we report the first examples of irreversible Cl2 capture via the dichlorination of alkene linkages in Zr-based metal–organic frameworks (MOFs). Frameworks constructed from fumarate (Zr-fum) and stilbene (Zr-stilbene) linkers retain long-range order and accessible porosity after alkene dichlorination. In addition, energy-dispersive X-ray spectroscopy (EDS) reveals an even distribution of Cl throughout both materials after Cl2 capture. Cl2 uptake experiments reveal high irreversible uptake of Cl2 (>10 wt %) at low partial pressures (<100 mbar), particularly in Zr-fum. In contrast, traditional porous carbons display mostly reversible Cl2 capture, representing a continued risk to users after exposure. Overall, our results support that alkene dichlorination represents a new pathway for reactive Cl2 capture, opening up new opportunities for binding this gas irreversibly in PPE.

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“…H9c2 cells were initially derived from embryonic rat ventricular tissue and could well model the responses of primary cardiomyocytes ( Kimes and Brandt, 1976 ). Indeed, H9c2 cells are widely used as an important in vitro model of H/R injury ( Ye et al, 2020 ; Chen et al, 2021 ). The present study also adopted H9c2 cells as the in vitro H/R model to examine the cardioprotective mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of Small Ubiquitin-Like Modifier 2 and Protein SUMOylation as a Cardioprotective Mechanism Against Myocardial Ischemia-Reperfusion Injury

Zhao

Zhang

et al. 2021

Front. Pharmacol.

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Background: Small ubiquitin-like modifier (SUMO) proteins modify proteins through SUMOylation as an essential protein post-translational modification (PTM) for regulating redox status, inflammation, and cardiac fibrosis in myocardial infarction. This study aimed to investigate whether natural product puerarin could alleviate myocardial ischemia/reperfusion injury (MI-RI) by targeting protein SUMOylation.Methods: Mouse MI-RI model was induced by ligating the left anterior descending (LAD) coronary artery and subsequently treated with puerarin at the dose of 100 mg/kg. Rat cardiomyocyte H9c2 cells were challenged by hypoxia/reoxygenation and treated with puerarin at concentrations of 10, 20, and 40 μM. The infarction area of mouse hearts was assessed by 2% TTC staining. Cell damage was analyzed for the release of lactate dehydrogenase (LDH) in serum and cell culture medium. Western blot technique was employed to detect the expression of SUMO2, phospho-ERK, pro-inflammatory biomarker COX2, fibrosis index galectin-3, apoptosis-related protein cleaved PARP-1. The activation of the estrogen receptor (ER) pathway was assayed by the dual-luciferase reporter system.Results: The present study validated that puerarin effectively reduced myocardial infarct size and LDH release in the mouse MI-RI model. In the cell culture system, puerarin effectively decreased the release of LDH and the protein level of COX2, galectin-3, and cleaved PARP-1. Mechanistic studies revealed that puerarin increased the expression of SUMO2, SUMOylation of proteins and the activation of ER/ERK pathway in cardiomyocytes. ER, ERK and SUMO2 inhibitors attenuated the cardioprotective effects of puerarin.Conclusion: Puerarin may alleviate myocardial injury by promoting protein SUMOylation through ER/ERK/SUMO2-dependent mechanism.

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Biocompatible metal–organic frameworks for the storage and therapeutic delivery of hydrogen sulfide

Abstract: Metal–organic frameworks enable the delivery of hydrogen sulfide (H2S), an endogenous gasotransmitter with potential therapeutic value for treating disorders such as ischemia-reperfusion injury.

Cited by 23 publications

References 67 publications

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Reactive Chlorine Capture by Dichlorination of Alkene Linkers in Metal–Organic Frameworks

Upregulation of Small Ubiquitin-Like Modifier 2 and Protein SUMOylation as a Cardioprotective Mechanism Against Myocardial Ischemia-Reperfusion Injury

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