Biocompatible Magnetic Polymer Carriers for In Vivo Radionuclide Delivery

Schütt, Wolfgang; Grüttner, Cordula; Teller, Joachim; Westphal, Fritz; Häfeli, Urs O.; Paulke, Bernd-Reiner; Goetz, Phil; Finck, W

doi:10.1046/j.1525-1594.1999.06278.x

Cited by 29 publications

(20 citation statements)

References 22 publications

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“…Considerable attention has recently been devoted to synthesis of iron oxide nanoparticles due to their potential applications in pigments, magnetic drug targeting, genes, radionuclides, magnetic resonance imaging, recording materials and catalysts [1][2][3][4][5][6]. When the particles become nanometric, the material exhibits superparamagnetic behavior, i.e.…”

Section: Introductionmentioning

confidence: 99%

Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats

Jalilian¹,

Panahifar

Akhlaghi³

et al. 2009

Radiochimica Acta

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Gallium-67 / Superparamagnetic iron oxide nanoparticles / Radiolabeling / Stability / BiodistributionSummary. Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67 Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe 3+ /Fe 2+ = 2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈ 5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67 Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The biodistribution of the radiolabeled SPION was checked in normal male rats up to 24 h compared to free Ga 3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelial system while the stability of the complex is highly retained.

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Section: Introductionmentioning

confidence: 99%

Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats

Jalilian¹,

Panahifar

Akhlaghi³

et al. 2009

Radiochimica Acta

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“…[42] 4-Magnetic microspheres of cisplastin and paclitaxel were used in localized hyperthermia for treatment of cancer. [43] 5-Magnetic microspheres can be used for stem cell extraction and bone marrow purging. [44] 6-Magnetic polystyrene microspheres have been used as specific cell labelling.…”

Section: Farah World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah¹

2017

WJPPS

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A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time.A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion.One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features. One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review is to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

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“…Magnetic microspheres of cisplastin and paclitaxel were used in localized hyperthermia for treatment of cancer [41].…”

Section: Applications Of Magnetic Microspheresmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah

2016

JAPLR

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A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time. A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion. One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features.One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

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Biocompatible Magnetic Polymer Carriers for In Vivo Radionuclide Delivery

Cited by 29 publications

References 22 publications

Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats

Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats

Magnetic Microspheres: A Novel Drug Delivery System

Magnetic Microspheres: A Novel Drug Delivery System

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