Biocompatible Hydrogel Film of Polyethylene Oxide-Polyethylene Glycol Dimetacrylate for Wound Dressing Application

Haryanto,; Fani,; Mahardian, A

doi:10.1088/1757-899x/288/1/012076

Cited by 14 publications

(5 citation statements)

References 12 publications

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“…The results showed that PEG MA/PEO 20% hydrogel films show the highest amount of gel fraction (76%), the highest tensile strength (0.65 MPa), and the lowest swelling ratio (235%). Based on these results, the researchers confirmed that PEG MA/PEO 20% hydrogel can be used in potential wound dressing applications (Mahardian and Fani, 2018). In another study, a composite nanofiber network of antimicrobial peptides (AMPs) and PEO was prepared by pressurized gyration method for wound healing applications and its antibacterial properties were evaluated on S. epidermidis species.…”

Section: Polyethylene Oxide (Peo)mentioning

confidence: 78%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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Skin, the largest biological organ, consists of three main parts: the epidermis, dermis, and subcutaneous tissue. Wounds are abnormal wounds in various forms, such as lacerations, burns, chronic wounds, diabetic wounds, acute wounds, and fractures. The wound healing process is dynamic, complex, and lengthy in four stages involving cells, macrophages, and growth factors. Wound dressing refers to a substance that covers the surface of a wound to prevent infection and secondary damage. Biomaterials applied in wound management have advanced significantly. Natural biomaterials are increasingly used due to their advantages including biomimicry of ECM, convenient accessibility, and involvement in native wound healing. However, there are still limitations such as low mechanical properties and expensive extraction methods. Therefore, their combination with synthetic biomaterials and/or adding bioactive agents has become an option for researchers in this field. In the present study, the stages of natural wound healing and the effect of biomaterials on its direction, type, and level will be investigated. Then, different types of polysaccharides and proteins were selected as desirable natural biomaterials, polymers as synthetic biomaterials with variable and suitable properties, and bioactive agents as effective additives. In the following, the structure of selected biomaterials, their extraction and production methods, their participation in wound healing, and quality control techniques of biomaterials-based wound dressings will be discussed.

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Section: Polyethylene Oxide (Peo)mentioning

confidence: 78%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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“…The slight increase may be due to the presence of PEO, which has been reported to increase the swelling ratio of chitosan and CS/PEO hydrogels [53]. Haryanto et al on the other hand reported a swelling ratio of 8.00 for PEO hydrogels [54], while Mizraei et al reported 8.50 for CS/PEO blends [55].…”

Section: Swelling Ratiomentioning

confidence: 96%

Impact of Surface Area on Sensitivity in Autonomously Reporting Sensing Hydrogel Nanomaterials for the Detection of Bacterial Enzymes

Kinyua

Owino²,

Kaur³

et al. 2022

Chemosensors

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The rapid and selective detection of bacterial contaminations and bacterial infections in a non-laboratory setting using advanced sensing materials holds the promise to enable robust point-of-care tests and rapid diagnostics for applications in the medical field as well as food safety. Among the various possible analytes, bacterial enzymes have been targeted successfully in various sensing formats. In this current work, we focus on the systematic investigation of the role of surface area on the sensitivity in micro- and nanostructured autonomously reporting sensing hydrogel materials for the detection of bacterial enzymes. The colorimetric sensing materials for the detection of β-glucuronidase (ß-GUS) from Escherichia coli (E. coli) were fabricated by template replication of crosslinked pullulan acetoacetate (PUAA) and by electrospinning chitosan/polyethylene oxide nanofibers (CS/PEO NFs), both equipped with the chromogenic substrate 5-bromo-4-chloro-3-indolyl-β-D-glucuronide. The investigation of the dependence of the initial reaction rates on surface area unveiled a linear relationship of rate and thereby time to observe a signal for a given concentration of bacterial enzyme. This knowledge was exploited in nanoscale sensing materials made of CS/PEO NFs with diameters of 295 ± 100 nm. Compared to bulk hydrogel slabs, the rate of hydrolysis was significantly enhanced in NFs when exposed to bacteria suspension cultures and thus ensuring a rapid detection of living E. coli that produces the enzyme β-GUS. The findings afford generalized design principles for the improvement of known and novel sensing materials towards rapid detection of bacteria by nanostructuring in medical and food related settings.

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“… 34 Haryanto and colleagues employed an electron beam irradiation-based crosslinking technique to generate polyethylene oxide-PEG dimetacrylate for wound dressing applications. 35 …”

Section: Introductionmentioning

confidence: 99%

“…By using direct-writing melt electrospinning, fiber mats of poly(ε-caprolactone) (PCL), PEG, and Ciprofloxacin (CPFX) with various geometric configurations were effectively manufactured, and the releasing behavior of CPFX was examined in vitro by He et al Similarly, the PCL/PEG diacrylate (PEGDA)/copper oxide-exchange zeolite (Z-CuO) composites synthesized by the semi-interpenetrating network were explored by Mahdis and colleagues . Haryanto and colleagues employed an electron beam irradiation-based crosslinking technique to generate polyethylene oxide-PEG dimetacrylate for wound dressing applications …”

Section: Introductionmentioning

confidence: 99%

Density Functional Theory Interaction Study of a Polyethylene Glycol-Based Nanocomposite with Cephalexin Drug for the Elimination of Wound Infection

Adekoya

Sadiku

et al. 2022

ACS Omega

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In this paper, density functional theory (DFT) simulations are used to evaluate the possible use of a graphene oxide-based poly(ethylene glycol) (GO/PEG) nanocomposite as a drug delivery substrate for cephalexin (CEX), an antibiotic drug employed to treat wound infection. First, the stable configuration of the PEGylated system was generated with a binding energy of −25.67 kcal/mol at 1.62 Å through Monte Carlo simulation and DFT calculation for a favorable adsorption site. The most stable configuration shows that PEG interacts with GO through hydrogen bonding of the oxygen atom on the hydroxyl group of PEG with the hydrogen atom of the carboxylic group on GO. Similarly, for the interaction of the CEX drug with the GO/PEG nanocomposite excipient system, the adsorption energies are computed after determining the optimal and thermodynamically favorable configuration. The nitrogen atom from the amine group of the drug binds with a hydrogen atom from the carboxylic group of the GO/PEG nanocomposite at 1.75 Å, with an adsorption energy of −36.17 kcal/mol, in the most stable drug–excipient system. Drug release for tissue regeneration at the predicted target cell is more rapid in moist conditions than in the gas phase. The solubility of the suggested drug in the aqueous media around the open wound is shown by the magnitude of the predicted solvation energy. The findings from this study theoretically validate the potential use of a GO/PEG nanocomposite for wound treatment application as a drug carrier for sustained release of the CEX drug.

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Biocompatible Hydrogel Film of Polyethylene Oxide-Polyethylene Glycol Dimetacrylate for Wound Dressing Application

Cited by 14 publications

References 12 publications

A review of the current state of natural biomaterials in wound healing applications

A review of the current state of natural biomaterials in wound healing applications

Impact of Surface Area on Sensitivity in Autonomously Reporting Sensing Hydrogel Nanomaterials for the Detection of Bacterial Enzymes

Density Functional Theory Interaction Study of a Polyethylene Glycol-Based Nanocomposite with Cephalexin Drug for the Elimination of Wound Infection

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