Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation

Santos, Carla I. M.; Gonçalves, Gil; Cicuéndez, Mónica; Mariz, Inês F. A.; Silva, Virgília S.; Oliveira, Helena; Campos, Fabio de; Vieira, Sandra I.; Marques, Paula A.A.P.; Maçôas, Ermelinda; Neves, Maria G. P. M. S.; Martinho, J. M. G.

doi:10.1016/j.carbon.2018.04.040

Cited by 21 publications

(22 citation statements)

References 71 publications

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“…The unique properties of graphene oxide, such as a large surface area decorated with different functional groups, biocompatibility, a lack of obvious toxicity, photothermal activity, intrinsic high near-infrared absorbance, and water solubility, are making it an ideal material to carry PSs [ 188 ]. Under this context, and considering the attention given to PDI as an effective approach to improve root canal disinfection, Tayebeh Akbaria et al [ 189 ] used functionalized nano-graphene oxide (GO) with APTS and then with l -carnitine (GO-APTES-L CA) as a platform to load, via π-π stacking interactions, the amphiphilic dye indocyanine green (ICG), also known as Cardio-Green ® ( Figure 35 ).…”

Section: Supports Based On Carbon Nanomaterialsmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Supports Based On Carbon Nanomaterialsmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…Graphene and its derivatives were widely investigated due to their excellent conductivity, biocompatibility, non-toxicity, and photothermal activity 38. Recently, much attention was transferred to target microbial pathogens, which was becoming increasingly resistant to conventional therapy 39–42. Graphene oxide (GO) had unique properties such as a large surface area decorated with different functional groups, intrinsic high NIR absorbance and well-dispersed stability in aqueous solution, and was an ideal nanoplatform for PS delivery.…”

Section: Nanomaterials In Apdtmentioning

confidence: 99%

<p>Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases</p>

Qi¹,

Chi²,

Sun³

et al. 2019

IJN

116

100

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Oral diseases such as tooth caries, periodontal diseases, endodontic infections, etc., are prevalent worldwide. The heavy burden of oral infectious diseases and their consequences on the patients’ quality of life indicates a strong need for developing effective therapies. Advanced understandings of such oral diseases, e.g., inflammatory periodontal lesions, have raised the demand for antibacterial therapeutic strategies, because these diseases are caused by viruses and bacteria. The application of antimicrobial photodynamic therapy (aPDT) on oral infectious diseases has attracted tremendous interest in the past decade. However, aPDT had a minimal effect on the viability of organized biofilms due to the hydrophobic nature of the majority of the photosensitizers (PSs). Therefore, novel nanotechnologies were rapidly developed to target the delivery of hydrophobic PSs into microorganisms for the antimicrobial performance improvement of aPDT. This review focuses on the state-of-the-art of nanomaterials applications in aPDT against oral infectious diseases. The first part of this article focuses on the cutting-edge research on the synthesis, toxicity, and therapeutic effects of various forms of nanomaterials serving as PS carriers for aPDT applications. The second part discusses nanomaterials applications for aPDT in treatments of oral diseases. These novel bioactive nanomaterials have demonstrated great potential to serve as carriers for PSs to substantially enhance the PDT therapeutic effects. Furthermore, the novel aPDT applications not only have exciting therapeutic potential to inhibit bacterial plaque-initiated oral diseases, but also have a wide applicability to other biomedical and tissue engineering applications.

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“…143 In another study, Santos et al reported the functionalization of GO directly to porphyrins previously functionalized with different glycol branches. [144] In this case, there was a primary step of carboxylation of GO using chloroacetic acid in basic conditions to maximize the number of À CO 2 H groups, which were then covalently linked (by ester bonds) to the glycol branches of the functionalized porphyrin (Scheme 8). In addition, such hybrids were proved to be successfully internalized into cancer cells (namely in the perinuclear area) and to be biocompatible in human Saos-2 osteoblasts, thus providing interesting findings to continue the study of such hybrids towards cancer therapies.…”

Section: Tgamentioning

confidence: 99%

“…As previously mentioned, Santos et al reported the synthesis of GO/porphyrin hybrids (Scheme 8) and their successful internalization into the perinuclear area of cancer cells. [144] More recently, Tománková et al reported the cellular uptake of a size-selected GO/TMPyP composite followed by internalization of TMPyP in the nuclei of HeLa cells. [203] In addition, GO/TMPyP showed higher ROS values and higher DNA damage followed by induction of apoptosis, when compared to non-functionalized TMPyP, which shows the potential of GO/porphyrin hybrids for clinical use.…”

Section: Applications Of Go/porphyrin Hybrids In Cancer Therapiesmentioning

confidence: 99%

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Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications

2020

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Among the available carbon nanomaterials, graphene oxide (GO) has been widely studied because of the possibility of anchoring different chemical species for a large number of applications, including those requiring water‐compatible systems. This Review summarizes the state‐of‐the‐art of synthetic routes used to functionalize GO, such as those involving multiple covalent and non‐covalent bonds to organic molecules, functionalization with nanoparticles and doping. As a recent development in this field, special focus is given to the formation of nanocomposites comprising GO and porphyrins, and their characterization through spectroscopic techniques (such as UV‐Vis, fluorescence, Raman spectroscopy), among others. The potential of such hybrid systems in targeted biological applications is also discussed, namely for cancer therapies relying on photodynamic and photothermal therapies and for the inhibition of telomerase enzyme. Lastly, some promising alternative materials to GO are presented to overcome current challenges of GO‐based research and to inspire future research directions in this field.

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Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation

Cited by 21 publications

References 71 publications

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

<p>Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases</p>

Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications

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