Biocompatible Heterostructured Nanoparticles for Multimodal Biological Detection

Choi, Jin Woo; Jun, Young‐wook; Yeon, Soo In; Kim, Hyoung Chan; Shin, Jeon Soo; Cheon, Jinwoo

doi:10.1021/ja066547g

Cited by 330 publications

(231 citation statements)

References 22 publications

(13 reference statements)

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“…For example, SPIO has been coated with a luminescent CdSe [60], or Yb or Er [61], or silica dye infused layer [62]. Exotic heterostructures have been reported containing combinations such as a quantum dot with an FePt particle [63] or an FePt and Au particle fusion [64]. In some of our work, we have reported Fe-Au nanoparticles.…”

Section: Multimodality Contrast Agentsmentioning

confidence: 85%

“…In work recently reported by our group, we have generated gadolinium-based MRI contrast agents and iron oxide-based probes that can be labeled with 64 Cu for PET imaging [68], [69]. These agents have potential for dualmode PET/MRI imaging of vascular inflammation.…”

Section: Multimodality Contrast Agentsmentioning

confidence: 99%

“…11, the polymer is the targeting component and consists of amino acid or nucleotide polymers (mal-BSA, polyI, or polyG) that are ligands recognized by macrophage scavenger receptors. The polymer is conjugated to chelators that can hold either paramagnetic gadolinium or 64 Cu. The chelator selected, DOTA binds strongly to either metal [76], [77].…”

Section: Design Of Dual-mode Pet/mri Agentsmentioning

confidence: 99%

“…The targeting polymer is a polysaccharide (dextran sulfate) conjugated to DOTA chelating 64 Cu. The two types of agents differ in their mechanism of MRI contrast.…”

Section: Cherry Et Al: Integration Of Pet With Mrimentioning

confidence: 99%

“…With extremely high sensitivity, PET allows the quantitative imaging of even relatively low abundance targets without introducing mass effects. PET radionuclides range from short-lived biologically relevant isotopes such as 15 OðT 1=2 ¼ 2 minÞ and 11 CðT 1=2 ¼ 20 minÞ to the clinically ubiquitous 18 FðT 1=2 ¼ 110 minÞ and longer lived radiohalogens and radiometals such as 64 CuðT 1=2 ¼ 12:6 hÞ, 76 BrðT 1=2 ¼ 16:1 hÞ, and 124 IðT 1=2 ¼ 4:2 dÞ. While the sensitivity for detection is several orders of magnitude better than MRI, the spatial resolution is significantly inferior, ranging from around 1 mm for preclinical PET scanners to 4-6 mm for human whole-body PET scanners.…”

Section: Introductionmentioning

confidence: 99%

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The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Cherry¹,

Louie

Jacobs

2008

Proc. IEEE

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| A number of laboratories and companies are currently exploring the development of integrated imaging systems for magnetic resonance imaging (MRI) and positron emission tomography (PET). Scanners for both preclinical and human research applications are being pursued. In contrast to the widely distributed and now quite mature PET/computed tomography technology, most PET/MRI designs allow for simultaneous rather than sequential acquisition of PET and MRI data. While this offers the possibility of novel imaging strategies, it also creates considerable challenges for acquiring artifact-free images from both modalities. This paper discusses the motivation for developing combined PET/MRI technology, outlines the obstacles in realizing such an integrated instrument, and presents recent progress in the development of both the instrumentation and of novel imaging agents for combined PET/MRI studies. The performance of the first-generation PET/MRI systems is described. Finally, a range of possible biomedical applications for PET/MRI are outlined.

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Section: Multimodality Contrast Agentsmentioning

confidence: 85%

Section: Multimodality Contrast Agentsmentioning

confidence: 99%

Section: Design Of Dual-mode Pet/mri Agentsmentioning

confidence: 99%

“…The targeting polymer is a polysaccharide (dextran sulfate) conjugated to DOTA chelating 64 Cu. The two types of agents differ in their mechanism of MRI contrast.…”

Section: Cherry Et Al: Integration Of Pet With Mrimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Cherry¹,

Louie

Jacobs

2008

Proc. IEEE

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Monodisperse Magnetic Nanoparticles: Chemical Synthesis and Surface Modification

Xie

Sun

2005

Encyclopedia of Inorganic Chemistry

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Magnetic nanoparticles, due to their prospective applications in data storage, drug delivery, hyperthermia, and magnetic resonance imaging, have attracted considerable attention in the past decade. From aqueous‐phase condensation to organic‐phase thermal decomposition, the synthesis of magnetic nanoparticles has been greatly improved. Nowadays, one can readily synthesize monodisperse magnetic nanoparticles with controlled sizes, shapes, and magnetic properties. In this article, we first briefly describe the general synthesis of monodisperse nanoparticles, and then focus on the synthesis of magnetic nanoparticles via thermal decomposition of metal precursors. The nanoparticles are grouped into ferrite, metallic, alloy, and multicomponent categories, and the mechanism for the formation of nanoparticles with critical parameters in determining size, shape, and multifunctionality is discussed. We further summarize the chemistry used for nanoparticle surface functionalization and briefly discuss the potential applications of these magnetic nanoparticles in biomedicine.

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MRI Contrast Agents Based on Inorganic Nanoparticles

Na¹,

Hyeon²

2011

Nanoplatform‐Based Molecular Imaging

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INTRODUCTIONMagnetic resonance imaging (MRI) is currently one of the most powerful diagnosis tools in medical science [1]. MRI produces images through monitoring the relaxation processes of water protons under a magnetic field. With this technique, it is possible to obtain realtime images of the internal anatomy and physiology of living organisms in a noninvasive manner. Since it can give anatomic images of soft tissue with high resolution, it has been the preferred tool for imaging the brain and the central nervous system, for assessing cardiac function, and for detecting tumors. Although MRI itself gives detailed images, making a diagnosis based purely on the resulting images may not be accurate since normal tissues and lesions often show small differences in relaxation time. There are several strategies to obtain high-resolution MR images such as the use of high magnetic field and the design of coil systems. In economical and practical terms, it is more feasible to develop supplements that can maximize the ability of imaging tools. One of the most effective supplements is a chemical compound known as a contrast agent that is introduced to a living body for the improvement of visibility in the image. In particular, biological and functional information can be obtained in image form as a result of the interrelation of the contrast agent and the biological system. Therefore a MRI contrast agent is an essential research field in biological and medical sciences to supply a vision for the analysis of biological information and the diagnosis of diseases.Most of the presently available MRI contrast agents are paramagnetic complexes, usually gadolinium (Gd 3+ ) chelates [2]. Among them, Gd-DTPA has been the most widely used. Its main clinical applications are focused on detecting the breakage of the blood-brain barrier (BBB) and on changes in vascularity, flow dynamics, and perfusion. Twenty years ago, a different class of contrast agent, superparamagnetic iron oxide (SPIO), was developed, and it has received great attention as a liver contrasting agent [3]. It was the first nanoparticulate MRI contrast agent and is still used clinically. Gd-based contrast agents Nanoplatform-Based Molecular Imaging Edited by Xiaoyuan Chen

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Biocompatible Heterostructured Nanoparticles for Multimodal Biological Detection

Cited by 330 publications

References 22 publications

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Monodisperse Magnetic Nanoparticles: Chemical Synthesis and Surface Modification

MRI Contrast Agents Based on Inorganic Nanoparticles

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