Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas

Gonçalves, Jenifer Pendiuk; Cruz, Anderson Fraga da; Nunes, A. M.; Meneghetti, Mário R.; Barros, Heloise Ribeiro de; Borges, Beatriz Santana; Medeiros, Lia Carolina Soares; Soares, Maurílio J.; Santos, Mayara Padovan dos; Grassi, Marco Tadeu; Rossi, Gustavo Rodrigues; Bellan, D. L.; Biscaia, Stellee Marcela Petris; Buzzo, João Luiz Aldinucci; Ribeiro, Yasmin Carla; Acco, Alexandra; Cardoso, Mateus Borba; Simas, Fernanda Fogagnoli; Trindade, Edvaldo S.; Riegel‐Vidotti, Izabel C.; Oliveira, Carolina Camargo de

doi:10.1016/j.ijbiomac.2021.06.172

Cited by 19 publications

(18 citation statements)

References 58 publications

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“…The dye is neutral at physiological pH, which allows it to diffuse freely across cell membranes, but becomes protonated and retained within acidic vesicles. Therefore, by dividing the absorbance of incorporated neutral red dye by the crystal violet stain absorbance (related to the number of cells), we compared the amount of acidic intracellular vesicles generated by each cell due to the absorption of nanoparticles 18,20,21 . Although not statistically significant, exposure of fibroblasts and macrophages to the three highest concentrations of NPs 1–2 krpm shows a trend of increasing cellular uptake in a concentration‐dependent manner, where 4 μg/mL increases by 35% for both cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…Before crystal violet dye elution, representative images of each experimental group were obtained using an inverted light microscope. For nanoparticle uptake estimation, the neutral red absorbance was normalized by the cell number (crystal violet absorbance) of each sample 16,20,21 …”

Section: Methodsmentioning

confidence: 99%

“…For nanoparticle uptake estimation, the neutral red absorbance was normalized by the cell number (crystal violet absorbance) of each sample. 16,20,21…”

Section: Biocompatibility Screeningmentioning

confidence: 99%

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Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

et al. 2023

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NiFeMo alloy nanoparticles were synthesized by co-precipitation in the presence of organic additives. Nanoparticles thermal evolution shows that there is a significant increase in the average size (from 28 to 60 nm), consolidating a crystalline structure of the same type as the Ni 3 Fe phase but with lattice parameter a = 0.362 nm. Measurements of magnetic properties follow this morphological and structural evolution increasing saturation magnetization (Ms) by 578% and reducing remanence magnetization (Mr) by 29%. Cell viability assays on as-synthesized revealed that nanoparticles (NPs) are not cytotoxic up to a concentration of 0.4 μg/mL for both non-tumorigenic (fibroblasts and macrophages) and tumor cells (melanoma).

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

et al. 2023

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“…Generally, CTAB, a positively charged surfactant, is used as a stabilizer in the synthesis of AuNPs, which is deemed cytotoxic. Therefore, a recent study by Goncalves and teammates synthesized the gum-arabic coated gold nanorods (GA-AuNRs) for treating aggressive melanoma conditions without severe toxicity to normal cells [ 164 ]. The GA is a negatively charged polysaccharide that selectively binds and encapsulates the CTAB electrostatically.…”

Section: Inorganic Nanoparticles For Skin Cancer Therapymentioning

confidence: 99%

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

et al. 2023

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Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic modification have further exacerbated skin cancer statistics. Current treatment modalities such as surgery, radiotherapy, conventional chemotherapy, targeted therapy, and immunotherapy are facing several issues related to cost, toxicity, and bioavailability thereby leading to declined anti-skin cancer therapeutic efficacy and poor patient compliance. In the context of overcoming this limitation, several nanotechnological advancements have been witnessed so far. Among various nanomaterials, nanoparticles have endowed exorbitant advantages by acting as both therapeutic agents and drug carriers for the remarkable treatment of skin cancer. The small size and large surface area to volume ratio of nanoparticles escalate the skin tumor uptake through their leaky vasculature resulting in enhanced therapeutic efficacy. In this context, the present review provides up to date information about different types and pathology of skin cancer, followed by their current treatment modalities and associated drawbacks. Furthermore, it meticulously discusses the role of numerous inorganic, polymer, and lipid-based nanoparticles in skin cancer therapy with subsequent descriptions of their patents and clinical trials. Graphical Abstract

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“…Arabic gum (AG) or acacia senegal (AS) is a dietary additive that gained popularity because of its diverse use in food manufacturing [1]. It works as a delivery system for many medications used in treating patients and can decrease the toxicity of other medications if used too [2][3][4][5]. At the same time, its antioxidant and anti-inflammatory effects made it a hot topic for evaluation in human diseases with background inflammation and activation of inflammatory cascades.…”

Section: Introductionmentioning

confidence: 99%

Arabic gum as a natural therapeutic agent for diabetic patients with CKD: A retrospective study

et al. 2023

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Arabic gum (AG) is a dietary additive widely used in food manufacture and drugs; it has also gained popularity as herbal tea that can cure diseases such as diabetes, hypertension, and chronic kidney disease. Studies showed its antioxidant and anti-inflammatory effects. In a retrospective study design, we included CKD patients taking AG for at least three months. Data were collected over one year for each patient: age, co-morbidities, duration, amount of AG used, serum creatinine, inflammatory markers, lipid profile, blood sugar, hemoglobin A1C, and blood pressure readings. For the changes in values and trends, we compared the values individually for each patient separately. A<b> </b>total of 30 patients consisted of 20 males (66.7%) and 10 females (33.3%), with a mean age of 63.2 years. The mean (M) eGFR pre-enrollment in the study was 23.5 ml/min (standard deviation [SD]=15.8), and the mean eGFR at the end of the study was 26.1 ml/min (SD=18.9, p=0.56). There was a significant difference in the eGFR after using AG between diabetics (M=31.3 ml/min, SD=18.5) and non-diabetics (M=20.5 ml/min, SD=18.2, p=0.03). With a history of catheterization, there was a significant difference in eGFR between patients who had catheterization (M=31.76, SD=20.86) and patients without catheterization (M=18.36, SD=13.08, p=0.04). No significant effect on lipid profile, or CRP, yet significant effect on blood sugar control (fasting blood sugar 0.0001, and HBAa1c 0.01). In conclusion, AG is a promising natural material that affects decreasing eGFR in CKD diabetics patients.

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Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas

Cited by 19 publications

References 58 publications

Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

Temperature influence on NiFeMo nanoparticles magnetic properties and their viability in biomedical applications

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Arabic gum as a natural therapeutic agent for diabetic patients with CKD: A retrospective study

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