Biocompatible gold nanoclusters: synthetic strategies and biomedical prospects

Zuber, Guy; Weiss, Étienne; Chiper, Manuela

doi:10.1088/1361-6528/ab2088

Cited by 37 publications

(19 citation statements)

References 148 publications

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“…Among the emerging approaches, nanomaterials have been valued and listed front as effective cancer killing agents. Taking advantages of their small size, good biocompatibilities and thermal transmission abilities, several nanomaterials exert excellent cancer killing abilities in recent researches [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Liu

Shi²,

Zhang

et al. 2021

Nanoscale Res Lett

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Non-small-cell lung cancer (NSCLC) has become the second most diagnosed malignant tumors worldwide. As our long-term interests in seeking nanomaterials to develop strategies of cancer therapies, we herein constructed novel CoFe2O4-quantum dots (QDs) with outstanding synergistic photothermal/photodynamic property which suppressed NSCLC efficiently without apparent toxicity. We showed that the combination of CoFe2O4-QDs + NIR treatment induces apoptosis of NSCLC cells. In addition, the CoFe2O4-QDs + NIR treatment also promotes reactive oxygen species generation to trigger cell death through regulating PI3K/AKT pathway. Moreover, the CoFe2O4-QDs + NIR treatment successfully eliminates tumor xenografts in vivo without apparent toxic effects. Taken together, we reported that the novel nanomaterials CoFe2O4-QDs could exhibit enhanced synergistic photothermal therapy and photodynamic therapy effect on killing NSCLC without toxicity, which could be a promising photosensitizer for NSCLC therapy.

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Section: Discussionmentioning

confidence: 99%

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Liu

Shi²,

Zhang

et al. 2021

Nanoscale Res Lett

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“…For that reason, the few reports that provide direct evidence of linkage through an amide bond are for small clusters. 30,31 One of the earliest reports demonstrated that a known gold cluster molecule (“Undecagold” Au 11 (PPh 3 ) 7 I 3 ) could be obtained in a water-soluble form and modified by conjugation of the Ph*-groups to biomolecular groups. 32 It formed abundantly because it has eight (8) extra or “free” electrons that occupy a closed-shell s 2 p 6 configuration of globular “superatomic” orbitals.…”

Section: Resultsmentioning

confidence: 99%

Activating a Silver Lipoate Nanocluster with a Penicillin Backbone Induces a Synergistic Effect against S. aureus Biofilm

et al. 2019

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Many antibiotic resistances to penicillin have been reported, making them obsolete against multiresistant bacteria. Because penicillins act by inhibiting cell wall production while silver particles disrupt the cell wall directly, a synergetic effect is anticipated when both modes of action are incorporated into a chimera cluster. To test this hypothesis, the lipoate ligands (LA) of a silver cluster (Ag29) of known composition (Ag29LA12)[3−] were covalently conjugated to 6-aminopenicillanic acid, a molecule with a β-lactam backbone. Indeed, the partially conjugated cluster inhibited an Staphylococcus aureus biofilm, in a dose–response manner, with a half-maximal inhibitory concentration IC50 of 2.3 μM, an improvement over 60 times relative to the unconjugated cluster (IC50 = 140 μM). An enhancement of several orders of magnitude over 6-APA alone (unconjugated) was calculated (IC50 = 10 000 μM). Cell wall damage is documented via scanning electron microscopy. A synergistic effect of the conjugate was calculated by the combination index method described by Chou–Talalay. This hybrid nanoantibiotic opens a new front against multidrug-resistant pathogens.

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“…As an alternative to organic dyes and QDots, M NCs have a crowd of strike features like ultrasmall size, water solubility, high fluorescent efficiency, large Stokes shifts, excellent photostability, and low cytotoxicity [182], making them become the safe and nontoxic clinical fluorescent contrast agents. In comparison to well-studied Au and Ag NCs [31,[183][184][185], relatively little research investigated the bioimaging application of fluorescent Pt NCs. In general, the imaging way of Pt NCs can be divided into two parts: (1) direct labelling without any other materials and (2) combination of certain biomolecule (e.g., proteins and DNA) to targeted imaging.…”

Section: Biological Applications Of Platinum Nanoclustersmentioning

confidence: 99%

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

Huang

et al. 2019

Journal of Nanomaterials

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Noble metal nanoclusters (M NCs), defined as an aggregation of a few to tens of atoms, are considered a borderline between atoms and metal nanoparticles (M NPs), which tends to exhibit molecule-like behaviours such as discrete electronic state and size-dependent fluorescence. In the past decades, gold and silver nanoclusters (Au NCs and Ag NCs) have been massively explored and utilized in the field of industrial catalysis, optoelectronic devices, biological imaging, environmental detection, clinical diagnoses, and treatment. The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and rarely discussed. This review firstly investigates the synthetic methodology of Pt NCs including template-assisted and template-free approaches and then introduces their unique optical, catalytic, and thermal properties. Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. On the whole, the development of Pt NCs has already gained delectable progress; however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future.

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Biocompatible gold nanoclusters: synthetic strategies and biomedical prospects

Cited by 37 publications

References 148 publications

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Activating a Silver Lipoate Nanocluster with a Penicillin Backbone Induces a Synergistic Effect against S. aureus Biofilm

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

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