Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells

Das, Manash R.; Mudigunda, Sushma V.; Darabdhara, Gitashree; Boruah, Purna K.; Ghar, Sachin; Rengan, Aravind Kumar; Das, Manash R.

doi:10.1016/j.jphotobiol.2020.112028

Cited by 36 publications

(10 citation statements)

References 37 publications

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“…The better efficiency of the Au NRTs can be attributed to the hollow porous structure of the nanorattles. Whereas, the better PPTT efficiency achieved in case of bimetallic Au−Pd NRT can be linked to the bifunctional effect [1a] that exists between Au and Pd in the present case.…”

Section: Resultsmentioning

confidence: 55%

“…Gold nanostructures have been the protagonist in most PPTT applications due to its ease in synthesis and shape and structure dependent extinction spectra which can be tuned from visible to NIR region [2a,6] . However, palladium, platinum, copper, and iron oxide nanomaterials are also gaining ground due to the varied features and advantages they possess over gold [1b,7–8] For example, palladium is attracting attention as phototransducers due to its excellent photostability, biocompatibility and photothermal conversion efficiencies [1a,7a,8b,9] Furthermore, bimetallic nanoparticles are also being explored for PPTT where the combination of metals results in the enhancement or suppression of certain physical as well as chemical properties which is greatly desired while producing photothermal agents [8b,10] . Though various gold nanostructures have been demonstrated for PPPT applications, after the report on NIR active palladium nanosheet, there has been a search for other metal nanostructures with better photothermal conversion efficiency for PPTT applications [11] .…”

Section: Introductionmentioning

confidence: 99%

“…Though various gold nanostructures have been demonstrated for PPPT applications, after the report on NIR active palladium nanosheet, there has been a search for other metal nanostructures with better photothermal conversion efficiency for PPTT applications [11] . Additionally, the higher melting point of bulk palladium compared to gold metal can provide an advantage towards better photothermal stability to Pd based nanomaterials [1a,7a,8b,9,11] . However, the comparative account of the PPTT activity of gold and palladium nanostructures remain unexplored.…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Performance of Near‐Infrared Light Responsive Monometallic Gold and Bimetallic Gold‐Palladium Nanorattles towards Plasmonic Photothermal Therapy

Singh

Jaiswal

2022

ChemistrySelect

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The effect of different sizes and shapes of nanomaterials on its extinction spectrum is well studied and accordingly researchers have designed various nanostructures having absorbance in the near infrared (NIR) region for plasmonic photothermal therapy (PPTT) applications. However, the comparative study between the NIR active nanomaterials having different elemental composition for PPTT applications is not well explored. Herein, we investigate the photothermal activity of two different NIR active nanorattles viz. gold nanorattle (Au NRT) and bimetallic gold‐palladium nanorattle (Au−Pd NRT) having identical morphology but different elemental composition. The prepared nanorattles were PEGylated to render biocompatibility and identical surface functionalities. The aqueous solution of both the NRTs displayed a significant rise in temperature upon NIR irradiation which was not compromised on repeated exposure to light. The PPTT applicability of both the nanorattles were evaluated which suggested that the bimetallic Au−Pd NRT have better photothermal conversion efficiency of 35.4 % and better photothermal killing ability towards breast cancer cell line (SK‐BR‐3) compared to that of monometallic Au NRT having photothermal conversion efficiency of only 19.8 %. Thus, the present study indicates that NIR active nanostructures based on palladium acts as a better phototransducing agent than that of gold with similar morphology.

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Section: Resultsmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigating the Performance of Near‐Infrared Light Responsive Monometallic Gold and Bimetallic Gold‐Palladium Nanorattles towards Plasmonic Photothermal Therapy

Singh

Jaiswal

2022

ChemistrySelect

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“…From Raman analysis, it was clear there was no significant change in the rGO structure in both monometallic and bimetallic nanocomposites. [55,56]…”

Section: Chemistryselectmentioning

confidence: 99%

A Facile Preparation of Reduced Graphene Oxide Capped AuAg Bimetallic Nanoparticles: A Selective Nanozyme for Glutathione Detection

et al. 2022

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Over the last decade, artificial enzymes (nanozymes) have undergone substantial development in the field of sensing. In this study, Au−Ag bimetallic nanoparticles (NPs) decorated on reduced graphene oxide sheets (AuAg‐rGO) nanocomposite has been developed as a novel colorimetric probe based on the peroxidase imitating activity of the nanozyme. AuAg‐rGO nanocomposite proved to feature an intrinsic peroxidase mimic activity, facilitating the oxidation of a peroxidase substrate like 3,3’,5,5’‐tetramethylbenzidine (TMB) with high efficiency to oxidised TMB (blue coloured product) with the aid of hydrogen peroxide (H2O2). The characteristic Michaelis‐Menten kinetics study allowed the establishment of the catalytic performance of AuAg‐rGO as an artificial enzyme. Glutathione (GSH) displays inhibiting effect on the oxidation of the peroxidase substrate, TMB. Therefore, AuAg‐rGO nanozyme was applied for detection of GSH and exhibited exceptional selectivity and sensitivity with a low limit of detection (LOD) of 38 nM within the 0–200 μM concentration range. The artificial nanozyme system reported here is simple, convenient, and straightforward for colorimetric sensing of GSH.

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“…Polydopamine (PDA) functionalized rGO nanosheets and AuPd NP-based nanocomposites were synthesized using chemical reduction. [54] Photothermal irradiation for 3 min at 915 nm resulted in a temperature rise of 51 ± 3 °C and led to ablation of MDAMB-231 cancer cells. This high-performing AuPd-rGO/ PDA nanocomposite demonstrated photothermal ablation of cancer cells at a low concentration of 25 µg mL −1 due to the synergistic effect of AuPd and rGO.…”

Section: Surface Functionalized With Nanoparticlesmentioning

confidence: 99%

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

et al. 2021

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drug delivery, bioimaging probes, antibacterial agents, and tissue engineering. [2] The advantage of GBMs over other nanomaterials (NMs) in biomedical application is their high specific surface area which allows high density functionalization and drug loading on both sides of the planar structure. [3] The π-conjugated system offers high capacity for GBMs to interact with various organic compounds with aromatic structures through π-π stacking during fabrication of graphene composites or for immobilization of biomolecules such as nucleic acids, peptides, antibodies, or other therapeutic substances. [4] The same properties may also raise concerns regarding the potential risk that GBMs may cause to human health through binding of key signaling molecules for example. GBMs may interact with biomolecules, changing the structure of protein or DNA or induce oxidative damage, and so on. [5] Therefore, prior to the widespread use of GBMs, it is imperative to evaluate their potential risk to environmental and human health and to establish a proactive approach for the safe design of these materials.In a recent review article, Fadeel et al. comprehensively examined the literature on the effects of GBMs on human health and the environment and gave an overview of the state-of-the-art of safety assessment of GBMs, highlighting the importance of The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

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Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells

Cited by 36 publications

References 37 publications

Investigating the Performance of Near‐Infrared Light Responsive Monometallic Gold and Bimetallic Gold‐Palladium Nanorattles towards Plasmonic Photothermal Therapy

Investigating the Performance of Near‐Infrared Light Responsive Monometallic Gold and Bimetallic Gold‐Palladium Nanorattles towards Plasmonic Photothermal Therapy

A Facile Preparation of Reduced Graphene Oxide Capped AuAg Bimetallic Nanoparticles: A Selective Nanozyme for Glutathione Detection

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

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