Biocompatible formulation of cationic antimicrobial peptide Polylysine (PL) through nanotechnology principles and its potential role in food preservation — A review

Namasivayam, S. Karthick Raja; John, Arun Ravi; Bharani, R. S. Arvind; Kavisri, M.; Moovendhan, Meivelu

doi:10.1016/j.ijbiomac.2022.09.238

Cited by 14 publications

(3 citation statements)

References 91 publications

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“…However, some positively charged polymers can have biological activity in their own right, as demonstrated in the example of PCL-poly(lysine-stat-(S-aroylthiooxime) polymersomes [53]. PolyLys is a positively charged antimicrobial peptide [54] that promotes bacterial death and cellular uptake via interactions with cell membranes. Incorporation within a copolymer provides increased peptide stability and at the same time serves as a hydrophilic block.…”

Section: Copolymer Typesmentioning

confidence: 99%

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Fonseca,

Jarak,

Victor

et al. 2024

Materials

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Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed of hydrophobic and hydrophilic blocks. They can encapsulate hydrophilic molecules in the aqueous core and hydrophobic molecules within the membrane. The composition of block copolymers can be tuned, enabling control of characteristics and properties of formed polymersomes and, thus, their application in areas such as drug delivery, diagnostics, or bioimaging. The preparation methods of polymersomes can also impact their characteristics and the preservation of the encapsulated drugs. Many methods have been described, including direct hydration, thin film hydration, electroporation, the pH-switch method, solvent shift method, single and double emulsion method, flash nanoprecipitation, and microfluidic synthesis. Considering polymersome structure and composition, there are several types of polymersomes including theranostic polymersomes, polymersomes decorated with targeting ligands for selective delivery, stimuli-responsive polymersomes, or porous polymersomes with multiple promising applications. Due to the shortcomings related to the stability, efficacy, and safety of some therapeutics in the human body, polymersomes as drug delivery systems have been good candidates to improve the quality of therapies against a wide range of diseases, including cancer. Chemotherapy and immunotherapy can be improved by using polymersomes to deliver the drugs, protecting and directing them to the exact site of action. Moreover, this approach is also promising for targeted delivery of biologics since they represent a class of drugs with poor stability and high susceptibility to in vivo clearance. However, the lack of a well-defined regulatory plan for polymersome formulations has hampered their follow-up to clinical trials and subsequent market entry.

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Section: Copolymer Typesmentioning

confidence: 99%

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Fonseca,

Jarak,

Victor

et al. 2024

Materials

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“…Overall, the integration of nanotechnology in the food industry has paved the way for significant advancements in detecting harmful substances, controlling flavor characteristics, and improving the bioavailability of food materials, contributing to the overall enhancement of food safety, quality, and consumer satisfaction. The rapid growth and widespread adoption of nanotechnology in various industries, including the food sector, have raised several ethical, regulatory, and safety concerns (Namasivayam et al 2022). Nanomaterials exhibit diverse biological and physicochemical characteristics compared to their bulk counterparts, making their risks unpredictable and necessitating careful evaluation and risk management.…”

Section: The Role Of Nanotechnology In Food Industrymentioning

confidence: 99%

Unveiling the Future: Nanotechnology's Role in Advanced Food Packaging

2024

Agrobiol. Rec.

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The integration of nanotechnology in the food industry has shown great potential for addressing challenges in food processing, packaging, and safety. This review explores the role of nanotechnology in enhancing food functioning, focusing on its impact on defense against chemical corrosion, improvement of physical properties, protection of food, detection of foodborne pathogens, defense against allergens, prevention of heavy metal contamination, and inhibition of biofilm formation. Nanoparticles have been identified as effective agents for preventing undesirable chemical reactions in food media, while also improving the stability and shelf life of food products. Additionally, the incorporation of nanomaterials has significantly enhanced the physical properties of food packaging materials, ensuring UV radiation protection and high flame resistance. Nanotechnology has played a crucial role in ensuring food safety by enabling the rapid and precise detection of foodborne pathogens and allergens, thus mitigating potential health risks. Furthermore, nanomaterials have demonstrated their effectiveness in removing heavy metal contaminants from food items and wastewater, contributing to environmental remediation efforts. The use of nanotechnology has also shown promise in inhibiting biofilm formation and preventing bacterial contamination in food processing industries. Despite the promising advancements, challenges related to the potential hazards of certain nanomaterials and their regulatory implications in the food industry need to be addressed. Future research endeavors are expected to focus on further optimizing nanotechnology applications to ensure sustainable and safe practices in the food industry.

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“…According to the study of Tuersuntuoheti et al, ε-PL has been employed for preserving postharvest fruits and vegetables, such as apple, bamboo shoot, kiwi, carrot, and citrus [14], and effectively inhibited the aging and extended the shelf life of fruits and vegetables. The application of ε-PL solution and its composite solution has demonstrated a significant enhancement in the storage quality of fresh food [16], leading to a reduction in water loss. Additionally, numerous researchers have observed a synergistic effect between ε-PL and various natural bacteriostatic agents [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chitosan Combined with ε-Polylysine Treatment on the Postharvest Quality and Antioxidant Status of Winter Jujube

Chang,

Zhang

2024

Journal of Food Processing and Preservation

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During storage, winter jujube often experiences physiological disorders that can result in postharvest quality deterioration. To address this concern, a combination of 1% chitosan (CTS) and varying concentrations (0.02, 0.2, and 2 mg mL-1) of ε-polylysine (ε-PL) was applied. The findings indicated that the treatment involving the combination of 1% CTS with 0.2 mg mL-1ε-PL exhibited superior efficacy in preserving the hardness and titratable acid content of winter jujube. Additionally, the jujube fruits of this treatment exhibited a deceleration in the rise of decay incidence, red index, and weight loss rate. Simultaneously, the application of CTS combined with ε-PL treatment improved the levels of antioxidant enzyme activities (SOD, CAT, POD, and APX) and enhanced contents of antioxidant compounds (AsA and GSH). Moreover, the generation of reactive oxygen species (H2O2 and O2-.) was suppressed. Consequently, CTS combined with ε-PL treatment effectively enhanced postharvest quality and regulated antioxidant status of winter jujube.

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Biocompatible formulation of cationic antimicrobial peptide Polylysine (PL) through nanotechnology principles and its potential role in food preservation — A review

Cited by 14 publications

References 91 publications

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Unveiling the Future: Nanotechnology's Role in Advanced Food Packaging

Effects of Chitosan Combined with ε-Polylysine Treatment on the Postharvest Quality and Antioxidant Status of Winter Jujube

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