Biocompatible fluorescent organic nanoparticles derived from glucose and polyethylenimine

Zhang, Xiqi; Zhang, Xiaoyong; Yang, Bin; Yang, Yang; Chen, Qiaomei; Wei, Yen

doi:10.1016/j.colsurfb.2014.10.027

Cited by 17 publications

(8 citation statements)

References 55 publications

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“…Among them, fluorescent organic nanoparticles (FONs) based on self-assembled molecular units have received increasing attention owing to their structural variability, low toxicity, and favorable biodegradability. Involved materials such as conjugated polymers, , semiconducting polymer dots, , and aggregation-induced-emission nanoparticles, have established a burgeoning field with bright prospects in analytical and biological applications.…”

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confidence: 99%

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Liu

Yang

et al. 2019

Anal. Chem.

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Fluorescent organic nanoparticles (FONs) are promising alternatives for biological imaging applications owing to the increasing concerns over the potential toxicity and poor degradability of inorganic particles-based probes. However, synthesis of stable, small-sized FONs in aqueous media remains challenging. Inspired by the self-polymerization chemistry of phenolic compounds, we demonstrate ultrafast synthesis of FONs (phenolic compound-derived FONs, PhFONs) from a variety of molecular building blocks including dopamine, norepinephrine, pyrogallol, and gallic acid, simply by nontherml plasma treatment at the aqueous interface. Specifically, using dopamine as the precursor, poly(dopamine) (PD)-FONs featuring a small size of 3 nm are obtained within 1 min. Compositional and structural characterizations confirm the polymeric architectures in PD-FONs. The PhFONs, with multicolor emissions, excellent biocompatibility, high stability, and sizedependent access into cell nucleus, are suitable for live cell imaging and developing nucleus-targeting imaging platforms.

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confidence: 99%

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Liu

Yang

et al. 2019

Anal. Chem.

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“…In addition, the lyophilized hydrogels had typical vibrations at around 3278 cm −1 (N−H stretching), 2820 cm −1 (C−H stretching), 1580 cm −1 (N−H bending), 1458 cm −1 (C−H bending), and 1124 cm −1 (C−N stretching), 43,49,50 which are the characteristic FT-IR peaks of PEI (Figure 3b). These peaks are mostly identical to the ones of carbon dots from glucose and PEI.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Fluorescent Nanofibrillar Hydrogels of Carbon Dots and Cellulose Nanocrystals and Their Biocompatibility

Sui

Zhang

Huang

et al. 2020

ACS Sustainable Chem. Eng.

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Synthetic nanofibrillar hydrogels resembling a natural extracellular matrix have emerged as a promising material in the biomedical field; however, achievement of multifunctional nanofibrillar hydrogels with good biocompatibility is still an important and challenging task. Herein, we report a fluorescent nanofibrillar hydrogel prepared with polyethyleneimine (PEI) and cellulose nanocrystals (CNCs) via one-step hydrothermal treatment. The nanofibrillar hydrogels are mainly formed from CNCs cross-linked by carbon dots (CDs) through hydrogen bonding and hydrophobic interactions. The nanostructures and the mechanical properties of the hydrogels are controlled by weight ratios of CNCs to PEI and the total concentration of CNCs and PEI. In comparison with other hydrogels from CNCs and CDs, the nanofibrillar hydrogels exhibit better mechanical properties with relatively high Young’s moduli. The hydrogels show relatively low cytotoxicity and good biocompatibility, which are demonstrated by in vitro cell culture and in vivo subcutaneous implantation in rats. This work provides a new approach to prepare biomimetic nanofibrillar hydrogels with fluorescence properties, thus offering a promising synthetic material resembling a natural extracellular matrix for bioapplications.

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“…The as‐prepared PEI‐CDs were firstly reported and the refluxing condition was referred to other literatures when obtaining PEI‐capped fluorescent organic nanoparticles (FONs) . Different from saccharides, CA with much carboxyl groups has simpler structure and it could be another candidate carbon source for fabrication of FONs.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis of CA‐derived PEI‐CDs using refluxing method was firstly reported. The refluxing operation was referred to previous report . In brief, 200 mg CA and 100 mg PEI was dispersed in 20 mL ultrapure water, and the solution was vigorously stirred for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Facile reflux synthesis of polyethyleneimine‐capped fluorescent carbon dots for sequential bioassays toward Cu²⁺/H₂S and its application for a logic system

Chen

Han

Lin

et al. 2019

Biotech and App Biochem

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In this work, we present a novel facile strategy for green synthesis of polyethyleneimine (PEI)-capped carbon dots (PEI-CDs), in which citric acid and PEI were chosen as reactants and highly fluorescent PEI-CDs could be readily obtained via a simple one-pot refluxing under 120 • C within 2 H. Fluorescence studies indicate that the as-prepared PEI-CDs exhibit strong fluorescence emission at 446 nm with excitation at 365 nm. Upon the sequential addition of Cu 2+ and H 2 S, PEI-CDs result in an interesting "ON−OFF−ON" three-state emission responses, promising a bifunctional sensory platform. Moreover, the Cu 2+ /H 2 S-facilated reversible fluorescence changes of PEI-CDs have demonstrated the design of an INHIBIT logic system based on Boolean logic.

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Biocompatible fluorescent organic nanoparticles derived from glucose and polyethylenimine

Cited by 17 publications

References 55 publications

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Fluorescent Nanofibrillar Hydrogels of Carbon Dots and Cellulose Nanocrystals and Their Biocompatibility

Facile reflux synthesis of polyethyleneimine‐capped fluorescent carbon dots for sequential bioassays toward Cu²⁺/H₂S and its application for a logic system

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Biocompatible fluorescent organic nanoparticles derived from glucose and polyethylenimine

Cited by 17 publications

References 55 publications

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Plasma Treatment Conversion of Phenolic Compounds into Fluorescent Organic Nanoparticles for Cell Imaging

Fluorescent Nanofibrillar Hydrogels of Carbon Dots and Cellulose Nanocrystals and Their Biocompatibility

Facile reflux synthesis of polyethyleneimine‐capped fluorescent carbon dots for sequential bioassays toward Cu2+/H2S and its application for a logic system

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Facile reflux synthesis of polyethyleneimine‐capped fluorescent carbon dots for sequential bioassays toward Cu²⁺/H₂S and its application for a logic system