Biocompatible core–shell electrospun nanofibers as potential application for chemotherapy against ovary cancer

Yan, Eryun; Fan, Yajing; Sun, Zeyang; Gao, Junkai; Hao, Xiaoyuan; Pei, Shichun; Wang, Cheng; Sun, Laijun; Zhang, Deqing

doi:10.1016/j.msec.2014.04.053

Cited by 93 publications

(30 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When the flow rate of the shell increased, the initial release reduced from 22% to 13% in 2 hours of time. However, total release of doxorubicin decreased from 68% to 43% when the flow rate increased [25]. Similar results in which acyclovir [26] and flurbiprofen axetil [27] were inserted in the core with a hydrophilic polymer were also obtained.…”

Section: Delivery Of Hydrophobic Drugs From Core-shell Nanofiberssupporting

confidence: 73%

“…In another example, an anticancer drug, doxorubicin was incorporated in the core of core-shell nanofibers consisting of polyvinyl alcohol (PVA) core and chitosan shell via electrospinning technique [25]. To prevent doxorubicin leakage from dissolution into the medium quickly, nanofibers were cross-linked with glutaraldehyde vapor for 3 minutes.…”

Section: Delivery Of Hydrophobic Drugs From Core-shell Nanofibersmentioning

confidence: 99%

See 1 more Smart Citation

Core-Shell Nanostructures for Drug Delivery and Theranostics

2018

View full text Add to dashboard Cite

additional parameters such as core to shell flow ratio, as well as interfacial tension to obtain nanofibers with core-shell structure and homogenous nanofiber production [6]. Core-shell nanofibers are of great significance to encapsulate various types of bioactive molecules including drugs, proteins, and genes for the sustained release of these molecules due to advantages summarized as follows: G possibility to obtain nanofibers from un-spinnable solutions [4,8], G preventing the burst release which might cause toxicological effects [4,9], G prolonging the time of release and exhibiting sustained release for a longer time [5,10], G controlling the release kinetics of bioactive molecules by changing the composition [11] or feed rate [12] of core and shell solutions, G encapsulating the unstable bioactive molecules in mild conditions and protecting biological activity of these molecules [9,13], and G loading more than one bioactive molecule in the same nanofiber and regulating the rate of release [10,14]. 13.2 Delivery of drugs from core-shell nanofibers 13.2.1 Delivery of hydrophilic drugs from core-shell nanofibers Prolonged release of hydrophilic drugs with the minimum release at the initial stage is a challenge because of their high solubility in aqueous medium. Using both

show abstract

Section: Delivery Of Hydrophobic Drugs From Core-shell Nanofiberssupporting

confidence: 73%

Section: Delivery Of Hydrophobic Drugs From Core-shell Nanofibersmentioning

confidence: 99%

Core-Shell Nanostructures for Drug Delivery and Theranostics

2018

View full text Add to dashboard Cite

show abstract

“…in 2014. Coaxial fiber membranes delivering DOX inhibit the cell viability of human ovary cancer cells in vitro . A more detailed investigation, including in vivo experiments, has been reported by the Zhou group in 2015.…”

Section: Recent Results and Applicationsmentioning

confidence: 96%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

View full text Add to dashboard Cite

The formation of fibers by electrospinning has experienced explosive growth in the past decade, recently reaching 4,000 publications and 1,500 patents per year. This impressive growth of interest is due to the ability to form fibers with a variety of materials, which lend themselves to a large and rapidly expanding set of applications. In particular, coaxial electrospinning, which forms fibers with multiple core−sheath layers from different materials in a single step, enables the combination of properties in a single fiber that are not found in nature in a single material. This article is a detailed review of coaxial electrospinning: basic mechanisms, early history and current status, and an in‐depth discussion of various applications (biomedical, environmental, sensors, energy, catalysis, textiles). We aim to provide readers who are currently involved in certain aspects of coaxial electrospinning research an appreciation of other applications and of current results.

show abstract

“…produced poly(butylene succinate) (PBS) /PEG C/S microfibers by coaxial electrospinning, leading to a release behavior of some hydrophobic drugs such as triclosan and curcumin. Yan et al . produced poly(vinyl alcohol) (PVA)/chitosan C/S nanofibers (Figure ) which can be used as a carrier for doxorubicin (DOX) delivery for chemotherapy of ovary cancer.…”

Section: C/s Nanofibersmentioning

confidence: 99%

Recent advances in core/shell bicomponent fibers and nanofibers: A review

Naeimirad

Ali

Kotek

et al. 2018

J of Applied Polymer Sci

139

103

View full text Add to dashboard Cite

There has been a steady progress in developing synthetic fibers in the past few years. Bicomponent fibers and nanofibers in a core/shell (C/S) configuration, including two dissimilar materials have presented unusual potential for use in many novel applications. These fibers can be produced using a variety of materials via different techniques i.e., coaxial melt spinning and electrospinning. In this review, we discuss the recent advances in C/S fibers and nanofibers' production. The first part has been assigned to the bicomponent fibers manufacturing technology, while production and applications of C/S nanofibers have been described in the second part.

show abstract

Biocompatible core–shell electrospun nanofibers as potential application for chemotherapy against ovary cancer

Cited by 93 publications

References 22 publications

Core-Shell Nanostructures for Drug Delivery and Theranostics

Core-Shell Nanostructures for Drug Delivery and Theranostics

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Recent advances in core/shell bicomponent fibers and nanofibers: A review

Contact Info

Product

Resources

About