Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Mustafa, Yasser Fakri

doi:10.1016/j.molstruc.2024.138193

Cited by 8 publications

(2 citation statements)

References 61 publications

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“…They have a bad biodegradability, are persistent in the environment, have a strong stench, and are poisonous and carcinogenic. 4–6 Discharging them into the hydrosphere is a substantial source of pollution due to their refractory nature. They are found in most industrial effluents, particularly those from the paper and textile sectors, which are hugely popular in both developing and wealthy nations.…”

Section: An Overview Of Chlorophenolsmentioning

confidence: 99%

Electrochemical sensors based on molecularly imprinted polymers for the detection of chlorophenols as emergent distributing chemicals (EDCs): a review

Kamel,

Abd-Rabboh

2024

Anal. Methods

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Section: An Overview Of Chlorophenolsmentioning

confidence: 99%

Electrochemical sensors based on molecularly imprinted polymers for the detection of chlorophenols as emergent distributing chemicals (EDCs): a review

Kamel,

Abd-Rabboh

2024

Anal. Methods

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“…Cadioprotective, [7,8] anticancer, [9,10] antibacterial, [11,12] antidiabetic, [13,14] anticoagulant, [15,16] antioxidant, [17,18] anti-Alzheimer's, [19,20] and anti-Parkinson's [21,22] actions are a few of these biologically significant characteristics. [23][24][25] The isolation of phytocoumarins is not a facile method since their molecular framework contains a cyclic ester that can be the target for various nucleophilic assaults. [26] Particular attention should be paid to improving this isolation type by using potent, eco-friendly, and selective methodologies.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Younes,

Mustafa

2024

Chemistry & Biodiversity

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For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90‐minute extraction duration and a 55°C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, 1H‐NMR, 13C‐NMR, and mass analysis. The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress‐mitigating characteristics, ranging from 71.51 to 81.48%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC50 values of 46.76–81.45 μg/ml). The isolates need to be taken into account as dual COX‐2/5‐LOX antagonists because they also showed a selective anti‐inflammatory effect

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Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Cited by 8 publications

References 61 publications

Electrochemical sensors based on molecularly imprinted polymers for the detection of chlorophenols as emergent distributing chemicals (EDCs): a review

Electrochemical sensors based on molecularly imprinted polymers for the detection of chlorophenols as emergent distributing chemicals (EDCs): a review

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

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