Biocompatible Chitosan Oligosaccharide Modified Gold Nanorods as Highly Effective Photothermal Agents for Ablation of Breast Cancer Cells

Manivasagan, Panchanathan; Bharathiraja, Subramaniyan; Moorthy, Madhappan Santha; Nguyen, Thanh Phuoc; Kim, Hyehyun; Phan, Thi Tuong Vy; Lee, Kang Dae

doi:10.3390/polym10030232

Cited by 41 publications

(23 citation statements)

References 41 publications

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“…By increasing the incident wavelength, the imaginary part of the permittivity of the gold nanoparticle is slightly increasing and requires designing the particle shape or decreasing the laser power [ 28 ]. We can note that our results have been compared to the experimental results of [ 6 , 7 , 8 , 9 , 10 ]. Our results are in agreement with the experimental ones (the absorption efficiencies due to the shape of the nanoparticles are counterbalanced by smaller laser power densities producing compatible heat sources Q and temperature elevations).…”

Section: Numerical Results and Discussionmentioning

confidence: 94%

“…Such therapies are non-invasive, as they do not require surgery. Thermal ablation involves the delivery of nanoparticles by injection and illumination by using a laser to produce local heating, which destroys the tumoral cell [ 6 , 7 , 8 , 9 , 10 ]. Nanoparticles with various shapes and sizes are therefore photothermal agents (PA).…”

Section: Introductionmentioning

confidence: 99%

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Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length

Grosges

Barchiesi

2018

Molecules

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In cancer therapy, the thermal ablation of diseased cells by embedded nanoparticles is one of the known therapies. It is based on the absorption of the energy of the illuminating laser by nanoparticles. The resulting heating of nanoparticles kills the cell where these photothermal agents are embedded. One of the main constraints of this therapy is preserving the surrounding healthy cells. Therefore, two parameters are of interest. The first one is the thermal ablation characteristic length, which corresponds to an action distance around the nanoparticles for which the temperature exceeds the ablation threshold. This critical geometric parameter is related to the expected conservation of the body temperature in the surroundings of the diseased cell. The second parameter is the temperature that should be reached to achieve active thermal agents. The temperature depends on the power of the illuminating laser, on the size of nanoparticles and on their physical properties. The purpose of this paper is to propose behavior laws under the constraints of both the body temperature at the boundary of the cell to preserve surrounding cells and an acceptable range of temperature in the target cell. The behavior laws are deduced from the finite element method, which is able to model aggregates of nanoparticles. We deduce sensitivities to the laser power and to the particle size. We show that the tuning of the temperature elevation and of the distance of action of a single nanoparticle is not significantly affected by variations of the particle size and of the laser power. Aggregates of nanoparticles are much more efficient, but represent a potential risk to the surrounding cells. Fortunately, by tuning the laser power, the thermal ablation characteristic length can be controlled.

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Section: Numerical Results and Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length

Grosges

Barchiesi

2018

Molecules

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“…Because of its high water solubility, short chain length, low viscosity, and antitumor properties, COL is suitable for pharmaceutical and biomedical applications [17,18]. The potential of COL as a carrier for imaging agents and anticancer drugs has been suggested due to its efficient intracellular and site-specific delivery [19][20][21][22][23][24]. Due to its tumour targetability, the biocompatible COL could be successfully used for PTT when combined with NIR fluorophores to act as an imaging as well as photothermal agent.…”

Section: Introductionmentioning

confidence: 99%

Near-infra-red fluorescent chitosan oligosaccharide lactate for targeted cancer imaging and photothermal therapy

Lee

Jung

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Photothermal therapy (PTT) is a promising approach for effective cancer treatment because of its noninvasive procedure, low toxicity to normal tissues, and high tumour ablation efficiency. Developing a PTT agent with precise tumour imaging capabilities is an essential prerequisite for effective PTT. In this study, we developed a bifunctional near-infra-red (NIR) fluorescent conjugate consisting of chitosan oligosaccharide lactate (COL) and the ZW800-1 NIR fluorophore (COL-ZW). We demonstrate that this conjugate is easy to use and that it is an effective theranostic agent for fluorescence-guided photothermal treatment. The temperature of COL-ZW increased by 62.3 C after NIR laser irradiation (1.1 W/cm 2) for 5 min in HT-29 tumour-bearing mice. The HT-29 tumours targeted by COL-ZW showed a remarkable decrease in tumour volume until a week after photothermal treatment. These in vivo results demonstrate that the bifunctional COL-ZW generates strong fluorescence and light-triggered PTT in tumour sites, indicating successful fluorescence-guided PTT. Importantly, no tumour recurrence or treatmentinduced toxicity was observed after a single dose of COL-ZW with laser irradiation. Therefore, a combinatorial treatment with COL-ZW and NIR laser irradiation could serve as a promising strategy for photothermal cancer therapy.

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“…The tumor inhibition rate of AuNCs (86.65%) and AuNShs (72.39%) demonstrated the efficacy in photothermal therapy. Au nanorods, modified with lipoic acid (LA) and chitosan oligosaccharide (COS, introduced to reduce the cytotoxicity caused by CTAB), showed excellent characteristics for photothermal therapy both in in vivo as in in vitro experiments [ 98 ]. AuNRs@LA@COS could reach a temperature of 52.6 °C for 5 min of NIR laser irradiation at 2 W/cm 2 .…”

Section: Anisotropic Gold Nanoparticles In Therapeutics and Imaginmentioning

confidence: 99%

Anisotropic Gold Nanoparticles in Biomedical Applications

Kohout

Santi

Polito

2018

IJMS

100

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Gold nanoparticles (AuNPs) play a crucial role in the development of nanomedicine, principally due to their unique photophysical properties and high biocompatibility. The possibility to tune and customize the localized surface plasmon resonance (LSPR) toward near-infrared region by modulating the AuNP shape is one of the reasons for the huge widespread use of AuNPs. The controlled synthesis of no-symmetrical nanoparticles, named anisotropic, is an exciting goal achieved by the scientific community which explains the exponential increase of the number of publications related to the synthesis and use of such type of AuNPs. Even with such steps forward and the AuNP translation in clinic being done, some key issues are still remain and they are related to a reliable and scalable production, a full characterization, and to the development of nanotoxicology studies on the long run. In this review we highlight the very recent advances on the synthesis of the main classes of anisotropic AuNPs (nanorods, nanourchins and nanocages) and their use in the biomedical fields, in terms of diagnosis and therapeutics.

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Biocompatible Chitosan Oligosaccharide Modified Gold Nanorods as Highly Effective Photothermal Agents for Ablation of Breast Cancer Cells

Cited by 41 publications

References 41 publications

Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length

Gold Nanoparticles as a Photothermal Agent in Cancer Therapy: The Thermal Ablation Characteristic Length

Near-infra-red fluorescent chitosan oligosaccharide lactate for targeted cancer imaging and photothermal therapy

Anisotropic Gold Nanoparticles in Biomedical Applications

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