Biocompatible carboxymethylcellulose-g-poly(acrylic acid)/OMMT nanocomposite hydrogel for in vitro release of vitamin B<sub>12</sub>

Boruah, Monalisha; Gogoi, P. K.; Manhar, Ajay Kumar; Khannam, Momina; Mandal, Manabendra; Dolui, Swapan Kumar

doi:10.1039/c4ra07962k

Cited by 41 publications

(24 citation statements)

References 27 publications

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“…As is known, the key for the successful preparation of PLSN is to obtain a widely dispersed nanostructure which can lead to optimization of the organ‐clay performance in the polymer matrix. Many researchers have been interested in the influences of organic montmorillonite (OMMT) on the structure and properties of PLSN . For instance, Wang et al reported the effect of the addition of organoclay platelets on morphology and mechanical properties of poly(trimethylene terephthalate)/ethylene‐propylene‐diene copolymer grafted with maleic anhydride/organoclay (PTT/EPDM‐ g ‐MA/organoclay) nanocomposites and showed that almost all of the exfoliated or intercalated clay platelets existed in dispersed domains of the EPDM‐ g ‐MA phase and that enhanced mechanical properties were obtained .…”

Section: Introductionmentioning

confidence: 99%

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Guo

et al. 2017

Polymer Engineering & Sci

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Nanocomposites of organic nano-montmorillonite (nano-OMMT)-filled immiscible polyamide 6 (PA6)/polystyrene (PS) blends were prepared by three different processing methods. Masterbatch M1 of OMMT/PA6 and masterbatch M2 of OMMT/PS were prepared as separate masterbatchs by melt mixing with PA6 or PS, and then either mixed together or each mixed individually with appropriate amounts of PS or PA6, respectively. The effects of nano-OMMT content and processing method on the structure, phase morphology, and mechanical properties of the PA6/ PS/OMMT nanocomposites were investigated by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and mechanical properties tests. The results showed that the nano-OMMT by M1 and M2 masterbatches dispersed primarily as exfoliated platelets in the PA6 matrix in the final composites regardless of the method of preparation. A drastic decrease of dispersed PS phase size and a very homogeneous size distribution were observed with the addition of nano-OMMT. The PA6/ PS/OMMT nanocomposites prepared from the M2 displayed the smallest dispersed PS phase size and best distribution of OMMT. The improvement of the mechanical properties of the PA6/PS/OMMT nanocomposites was attributed to the enhanced compatibilization of the immiscible PA6/PS blends by using nano-OMMT. POLYM. ENG. SCI.,

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Section: Introductionmentioning

confidence: 99%

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Guo

et al. 2017

Polymer Engineering & Sci

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“…Moreover, the addition of montmorillonite shifted the dissolution-resistant properties of hydrogels, thereby affecting the release of drugs. 147 Kevadiya et al 148 synthesized montmorillonite/alginate nanocomposite hydrogels with the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug, into montmorillonite. Due to the host-guest intercalation and the pH-responsiveness of the alginate/montmorillonite nanocomposite hydrogels, LC was released from montmorillonite in the hydrogels in a controlled way.…”

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confidence: 99%

Recent advances in clay mineral-containing nanocomposite hydrogels

et al. 2015

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Clay mineral-containing nanocomposite hydrogels have been proven to have exceptional composition, properties, and applications, and consequently have attracted a significant amount of research effort over the past few years. The objective of this paper is to summarize and evaluate scientific advances in clay mineral-containing nanocomposite hydrogels in terms of their specific preparation, formation mechanisms, properties, and applications, and to identify the prevailing challenges and future directions in the field. The state-of-the-art of existing technologies and insights into the exfoliation of layered clay minerals, in particular montmorillonite and LAPONITE s , are discussed first. The formation and structural characteristics of polymer/clay nanocomposite hydrogels made from in situ free radical polymerization, supramolecular assembly, and freezing-thawing cycles are then examined. Studies indicate that additional hydrogen bonding, electrostatic interactions, coordination bonds, hydrophobic interaction, and even covalent bonds could occur between the clay mineral nanoplatelets and polymer chains, thereby leading to the formation of unique three-dimensional networks. Accordingly, the hydrogels exhibit exceptional optical and mechanical properties, swelling-deswelling behavior, and stimuli-responsiveness, reflecting the remarkable effects of clay minerals. With the pivotal roles of clay minerals in clay mineral-containing nanocomposite hydrogels, the nanocomposite hydrogels possess great potential as superabsorbents, drug vehicles, tissue scaffolds, wound dressing, and biosensors. Future studies should lay emphasis on the formation mechanisms with in-depth insights into interfacial interactions, the tactical functionalization of clay minerals and polymers for desired properties, and expanding of their applications.

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“…The proposed system revealed biocompatibility and more than 99% antibacterial activity . Boruah et al . developed a hydrogel based on carboxymethylcellulose and AAc with incorporated organically modified MMT clay to demonstrate the in vitro blood compatibility of the nanocomposite hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂

Nath¹,

Chowdhury²,

Ali³

et al. 2019

J of Applied Polymer Sci

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Gelatin (Ge)‐g‐poly(acrylic acid‐co‐acrylamide) and montmorillonite (MMT)‐clay‐based nanocomposite hydrogels were fabricated to study the controlled release of vitamin B12. Polymeric hydrogels were characterized with Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR spectroscopy confirmed the grafting of partially neutralized acrylic acid on a Ge backbone. The incorporation of MMT fillers inside the nanocomposite hydrogels and their increased crystallinity were established by XRD analysis. The rough surface morphologies of the composite hydrogels shown by SEM resulted from the assimilation of MMT inside the same. TEM confirmed the formation of nanosized composites. The average length and width of the MMT platelets were found to be 184.37 and 20.48 nm, respectively. The maximum swelling of the hydrogel was 375 g/g, and the results were established with Design‐Expert software. The biodegradability of the nanocomposite increased in comparison to that of the copolymer hydrogel. Biocompatibility and cytotoxicity studies were also performed. During different time intervals, the controlled release of vitamin B12 in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) was evaluated with a UV–visible spectrophotometer; this resulted in different controlled release curves. The release in AGF was 42%, and in AIF, the cumulative release was 80% over 6 h. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47596.

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Biocompatible carboxymethylcellulose-g-poly(acrylic acid)/OMMT nanocomposite hydrogel for in vitro release of vitamin B₁₂

Cited by 41 publications

References 27 publications

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Recent advances in clay mineral-containing nanocomposite hydrogels

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂

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Biocompatible carboxymethylcellulose-g-poly(acrylic acid)/OMMT nanocomposite hydrogel for in vitro release of vitamin B12

Cited by 41 publications

References 27 publications

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Phase morphology evolution and compatibilization of immiscible polyamide 6/polystyrene blends using nano‐montmorillonite

Recent advances in clay mineral-containing nanocomposite hydrogels

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B12

Contact Info

Product

Resources

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Biocompatible carboxymethylcellulose-g-poly(acrylic acid)/OMMT nanocomposite hydrogel for in vitro release of vitamin B₁₂

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂