Biocompatible carboxymethyl chitosan-modified glass ionomer cement with enhanced mechanical and anti-bacterial properties

Kashyap, Preety Kumari; Chauhan, Sonal; Negi, Yuvraj Singh; Goel, Narendra S.; Rattan, Sunita

doi:10.1016/j.ijbiomac.2022.11.028

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…They claimed that this newly developed material has anticariogenic and cytotoxic properties. 25 New biocompatible products can be used as a result of the non-cytotoxic properties discovered in our study.…”

Section: Figurementioning

confidence: 72%

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

ÜNAL,

GÜÇYETMEZ TOPAL,

HAZMAN

2024

Turkiye Klinikleri J Dental Sci

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Glass ionomers, commonly used as base materials, are also employed as restorative materials after modifications are made to their content. By altering their physical properties through additives, attempts have been made to impart antibacterial characteristics. This study aimed to assess the cytotoxic effects resulting from the addition of calcium carbonate (marble powder) to conventional glass ionomer luting cement on gingival fibroblast cells. Material and Methods: Conventional glass ionomer cement (Ionofil U, VOCO, Germany) was used in this study. The specimens were divided into three groups: Group A-Glass ionomer without marble particles (control). Group B-Glass ionomer with 5% wt. Calcium Carbonate (marble particles) added to the powder component. Group C-Glass ionomer with 10% wt. Calcium carbonate (marble particles) added to the powder component. Prepared samples were kept in medium for 24 hours. The cytotoxicity levels of the biomaterials used in the study were determined using the MTT (3-4.5-dimethyl-thiazolyl-2.5-diphenyltetrazolium bromide) method on gingival fibroblast cell. Statistical evaluation was performed using one-way analysis of variance and post hoc Duncan test (p<0.05). Results: Biomaterials other than those in Group A, when applied to fibroblast cells, did not exhibit cytotoxicity; instead, they stimulated fibroblast cell proliferation. Group A reduced fibroblast cell viability rates at concentrations of 100%, 50%, and 25%. Conclusion: Marble powder enhanced glass ionomers showed potential for clinical applications as samples did not show cytotoxic effects. Further physical tests are needed to assess the clinical suitability of the materials.

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Section: Figurementioning

confidence: 72%

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

ÜNAL,

GÜÇYETMEZ TOPAL,

HAZMAN

2024

Turkiye Klinikleri J Dental Sci

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“…14 However, the mixing technique for modified GIC and chitosan mentioned by Bao et al and Kashyap et al were different compared with Mulder and Anderson-Small using a w/w% ratio and analyzing the ion release that affected remineralization in carious dentin. 12,13,15 The modification of CMC-ACP as scaffolds with various concentration (1%, 2.5%, 5%, and 10%) showed higher calcium and phosphate level when applying 10% CMC/ACP on demineralized dentin. 16 Mulder and Anderson-Small found that the combination of chitosan with GIC enhances the ion release capabilities of GIC.…”

Section: Introductionmentioning

confidence: 99%

“…12 Kashyap et al, in their study, used a modified GIC powder (homogenized in a ball mill) with the addition of carboxymethyl chitosan (10 wt.%) to form a carboxymethyl-chitosan-modified glass powder (CMC-m-GP), improved compressive strength and flexural strength. 13 Studies by Pratiwi et al showed that modifying the GIC using the Xylotrupes gideon nano-chitosan increased the cracks on the surface morphology of GIC. 14 However, the mixing technique for modified GIC and chitosan mentioned by Bao et al and Kashyap et al were different compared with Mulder and Anderson-Small using a w/w% ratio and analyzing the ion release that affected remineralization in carious dentin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Physical Properties in Carboxymethyl Chitosan Modified Glass Ionomer Cements and the Effect for Dentin Remineralization: SEM/EDX, Compressive Strength, and Ca/P Ratio

Putranto,

Meidyawati,

Dwiseptyoga

et al. 2024

Eur J Dent

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Objective The aim of this article was to evaluate the effects of modifying glass ionomer cement (GIC) with carboxymethyl chitosan (CMC) on surface morphology and remineralization outcomes by examining dentin morphology and calcium ion composition changes. Materials and Methods Thirty holes in a cylindrical acrylic mold were filled with three groups of restorative materials: GIC, GIC modified with CMC (GIC-CMC) 5%, and GIC-CMC10%. The surface morphology of each group's materials was observed using scanning electron microscopy (SEM). The compressive strength measurement was performed using a universal testing machine. The dentin remineralization process was performed by applying GIC, GIC-CMC5%, and GIC-CMC10% materials for 14 days on demineralized dentin cavities treated with 17% ethylenediamine tetraacetic acid (EDTA) for 7 days. A morphological evaluation was conducted using SEM. The calcium ion composition and calcium-to-phosphorous (Ca/P) ratio were examined using an energy-dispersive X-ray (EDX). Statistical Analysis The Kruskal–Wallis and post-hoc Mann–Whitney U tests were performed to compare all four groups of calcium ions (p < 0.05). Results The modification of GIC with CMC affected the morphological changes in the materials in the form of reduced porosity and increased fractures. A significant difference was found in compressive strength between the GIC-CMC modification materials of GIC-CMC5% and GIC-CMC10% and the GIC control group. The dentin tubule morphology and surface changes were observed after applying GIC, GIC-CMC5%, and GIC-CMC10% materials for 14 days, as evaluated by SEM. The EDX examination showed an increase in calcium ion content and hydroxyapatite formation (Ca/P ratio) after applying the GIC-CMC10% material. Conclusion The surface porosity of the GIC modification material with the addition of CMC tended to decrease. However, an increase in cracked surfaces that widened, along with the rise in CMC percentage, was found. This modification also reduced the compressive strength of the materials, with the lowest average yield at 10% CMC addition. Therefore, the modification of GIC with CMC affects changes in morphology, calcium ion composition, and Ca/P ratio in demineralized dentin.

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“…[17][18][19][20][21][22] CMC is one of the most commonly used cellulose esters in biomedical applications. [23][24][25] It is a very water-soluble cellulose derivative. It is a bioadhesive polymer that can adhere to mucous membranes support salivation, movement, and swallowing in the mouth over a prolonged period of time.…”

Section: Introductionmentioning

confidence: 99%

“…CH is a natural biocompatible and biodegradable polymer with low toxicity obtained from the exoskeleton of crustaceans, insects, and fungi. [25][26][27][28] It also has excellent filmforming properties. CH-porous matrices have been used for various applications, such as periodontal bone regeneration, pancreatic islet cultivation, and as peptide/protein carriers.…”

Section: Introductionmentioning

confidence: 99%

Exploring Interactions and Properties of the Sodium Carboxymethyl Cellulose–Chitosan Biopolymer Complex

Ardhaoui,

Cherif,

Herth

2024

Physica Status Solidi (a)

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The complex of sodium carboxymethyl cellulose (CMC) and chitosan (CH) in aqueous solution can be used for biomedical applications and is very beneficial for tissue engineering, drug delivery, and disease treatment. This article presents elaboration and properties of the complex of two polysaccharides with opposite charges of CMC/CH in aqueous solutions. The electrical conductivity under the influence of increasing concentrations of the CMC/CH mixtures from (0.5 to 10) g l−1 and increasing temperatures from 288.15 to 318.15 K is investigated. The reduced conductivities, , energy of activation , the Gibbs free energy of conductivity , and the activations parameters of the enthalpy () and entropy () are estimated.

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Biocompatible carboxymethyl chitosan-modified glass ionomer cement with enhanced mechanical and anti-bacterial properties

Cited by 9 publications

References 38 publications

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

Evaluation of Cytotoxic Effect on Modified Glass Ionomer Cement with Calcium Carbonate: An in vitro Study

Evaluation of Physical Properties in Carboxymethyl Chitosan Modified Glass Ionomer Cements and the Effect for Dentin Remineralization: SEM/EDX, Compressive Strength, and Ca/P Ratio

Exploring Interactions and Properties of the Sodium Carboxymethyl Cellulose–Chitosan Biopolymer Complex

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