Biocompatible anti-microbial coatings for urinary catheters

Thompson, Vaness C; Adamson, Penny; Dilag, Jessirie; Liyanage, Dhanushka Bandara Uswatte Uswatte; Srikantharajah, Kagithiri; Blok, Andrew J.; Ellis, Amanda; Gordon, David L.; Köper, Ingo

doi:10.1039/c6ra07678e

Cited by 18 publications

(12 citation statements)

References 39 publications

(47 reference statements)

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“…Such coatings frequently employed QACs, AMPs, or enzymes. A coating with immobilized QA moieties was fabricated via surface initiated activator regeneration by electron transfer-atom transfer radical polymerization (ARGET–ATRP) of [2-(methacryloyloxy)ethyl]trimethylammonium chloride (MTAC) using a CuCl 2 catalyst, a tris(2-pyridylmethyl)amine ligand, and surface-grafted PDA-2-bromoisobutyryl bromide as the initiator . The CFU count on the coated catheter after incubation with E. coli or P. aeruginosa for 48 h was ≥50% lower compared to uncoated catheters.…”

Section: Dual-functional Coatings For Biomedical Applicationsmentioning

confidence: 99%

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Mitra

Kang

Neoh

2021

ACS Appl. Polym. Mater.

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One of the most detrimental consequences of surface colonization by bacteria is healthcare-associated infections (HAIs), which contribute to increased patient mortality and morbidity. Medical devices inserted into the body provide a route for bacterial migration and conducive surfaces for their attachment and proliferation. Antibacterial coatings can potentially minimize bacterial colonization and consequently reduce the occurrence of HAIs. Antibacterial coatings function by either inhibiting the attachment of bacteria (antifouling coatings) or killing bacteria attached to the surface and/or in the vicinity (bactericidal coatings). On an antifouling coating, any bacterium that manages to attach will proliferate, while on bactericidal coatings, the accumulation of dead bacteria and debris provides opportunities for other bacteria to colonize the surface. As such, the integration of antifouling and bactericidal functionalities in a single coating combines the advantages of each, increasing the probability that bacterial colonization can be successfully inhibited. This Review highlights recent developments in dual-functional polymer-based antibacterial coatings for specific biomedical applications. General strategies for endowing surfaces with either antifouling or bactericidal polymeric coatings are first discussed, followed by more detailed descriptions of coatings with integrated antifouling and bactericidal functionalities that target the important biomedical applications: blood-contacting devices, orthopedic implants, wound dressings, ocular devices, urinary catheters, endotracheal tubes, and hospital textiles. The importance of tailoring the coatings to meet the specific constraints and requirements of the intended application beyond the antibacterial functionality is emphasized, and finally, the potential challenges in translating such coatings to clinical application are highlighted.

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Section: Dual-functional Coatings For Biomedical Applicationsmentioning

confidence: 99%

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Mitra

Kang

Neoh

2021

ACS Appl. Polym. Mater.

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“…This type of coatings adsorbs both proteins and bacterial cells by electrostatic interaction through the negatively charged bacterial membrane, exerting an antimicrobial and anti-biofilm effect, simultaneously. [61,109,110] Both hydrophilic polymer-coated films [111] and catheters coated with amphiphilic polymers [112,113] demonstrated a high capability to reduce bacterial adhesion and subsequent biofilm formation. Lastly, polymer brushes have been developed to prevent microbial adhesion by limiting the contact of substratum with living microorganisms.…”

Section: Coatingsmentioning

confidence: 99%

Future Directions for Ureteral Stent Technology: From Bench to the Market

Domingues

Pacheco

Cruz

et al. 2021

Advanced Therapeutics

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Ureteral stents are broadly used for the treatment of a wide range of pathologies, with different complexities and characteristics. Despite being efficient, the morbidity associated with stents, such as bacterial infection and pain, limits their therapeutic action and often represents an increase in healthcare costs. As no single solution fits all problems, there is still a need to improve these medical devices. Throughout this review, the most recent innovations are outlined and suggestions regarding future directions for ureteral stent technology are formulated with respect to materials, coatings, and designs of these devices. As highlighted here, during the process of passing these innovations to the growing market of ureteral stents, one of the biggest challenges is to increase the predictive value of the in vitro assays and, consequently, reduce the number of in vivo tests needed. Thus, recommendations concerning in vitro standard testing of these devices are provided, with focus on medium, flow conditions, and microbiological parameters. Additionally, the reader is also presented with insights about a crucial but rarely discussed topic, the bureaucratic part of the bench to market process, particularly the product certification legislation in Europe.

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“…The α-bromoisobutyryl-functionalized DA entrapped in the modified PDA coating is presumably the initiator for the ATRP reaction, and this was used subsequently for the SI-ATRP growth of poly(methacrylate) brushes. Not surprisingly, the use of SI-ATRP pioneered by Zhu et al has proven to be extremely versatile, and has found applications in the preparation of substrate grafted polymer brushes for a wide variety of use, ranging from water purification membranes to hemocompatible surfaces …”

Section: Introductionmentioning

confidence: 99%

“…Not surprisingly, the use of SI-ATRP pioneered by Zhu et al 26 has proven to be extremely versatile, and has found applications in the preparation of substrate grafted polymer brushes for a wide variety of use, ranging from water purification membranes to hemocompatible surfaces. 27 However, despite the widespread usage of this method, an investigation into the efficacy of other 2-bromoisobutyrylmodified catechol derivatives for initiator immobilization and/ or subsequent SI-ATRP has not been undertaken, with the exception of an alkyl-bromide tripeptide with 3,4-dihydroxyphenylalanine (DOPA) and lysine residues reported by Messersmith et al 28 This is significant because under the conventional protocol, the modification of the free amino group of DA into an amide by α-bromoisobutyryl bromide would be expected to hinder cross-linking in the ATRPmodified PDA. Some steps in PDA film formation are known to involve cross-linking, which in turn requires the presence of the free amino group in DA.…”

Section: ■ Introductionmentioning

confidence: 99%

Evaluation of 2-Bromoisobutyryl Catechol Derivatives for Atom Transfer Radical Polymerization-Functionalized Polydopamine Coatings

Hsueh

Chai

2021

Langmuir

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The use of α-bromoisobutyryl-functionalized polydopamine (PDA), derived from an in situ mixture with dopamine (DA) and α-bromoisobutyryl bromide, enables surface-initiated atom transfer radical polymerization (SI-ATRP) of a broad range of methacrylate monomers for surface functionalization. Although the putative intermediate 2-bromo-N-(3,4-dihydroxyphenethyl)-2methylpropanamide 1 has been proposed to account for the SI-ATRP activity of α-bromoisobutyryl-functionalized PDA, there has not been a systematic investigation on the efficacy of other catechol-derived 2-bromoisobutyryl derivatives for SI-ATRP. In this work, a number of catechol-derived ATRP initiators containing the 2-bromoisobutyryl moiety were designed and synthesized, in an effort to investigate the effect of changes in structure on initiator immobilization, and subsequent ATRP performance. The change in the length of the linker unit bearing the 2bromoisobutyryl moiety, the introduction of a free amine group, or the replacement of the amide with an ester were found to have profound effects on the ability of the molecule to deposit ATRP-initiator-modified PDA coatings, as well as the subsequent SI-ATRP performance. Among the ATRP initiators synthesized, 5-(2-aminoethyl)-2,3-dihydroxyphenethyl 2-bromo-2-methylpropanoate hydrobromide 4•HBr was most efficiently incorporated into ATRP-initiator-modified PDA coatings and also the best at effecting SI-ATRP with 2-hydroxyethyl methacrylate; the high performance of this initiator is likely due to the presence of a free amine and an appropriately long methylene linker unit to the 2-bromoisobutyryl moiety. This methodology was found to be suitable for the functionalization of a range of organic and inorganic surfaces, for the fabrication of high-value surface-grafted polymer brush coatings for various applications.

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Biocompatible anti-microbial coatings for urinary catheters

Cited by 18 publications

References 39 publications

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Future Directions for Ureteral Stent Technology: From Bench to the Market

Evaluation of 2-Bromoisobutyryl Catechol Derivatives for Atom Transfer Radical Polymerization-Functionalized Polydopamine Coatings

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