Biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (review of literature)

Кузнецова, Т А; Беседнова, Н. Н.; Usov, V. V.; Андрюков, Б. Г.

doi:10.24884/0042-4625-2020-179-4-109-115

Cited by 9 publications

(2 citation statements)

References 36 publications

(9 reference statements)

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“…For example, there are products presented in the form of matrices, lyophilisates, powders, films, hydrogels, sponge materials, and patches [3,4]. The functional feature of many surgical materials is a complex favorable effect on tissues: they may be carriers of medicinal agents and deliver biologically active substances, growth factors, and regeneration stimulators to the damaged zone [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Selection of the Optimal Method for Creating Various Forms of Biocompatible Xenodermal Materials

Melkonyan¹,

Y.A.²,

Verevkin³

et al. 2022

Sovrem Tehnol Med

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The aim of the study was to select the optimal method for creating surgical porcine dermis-based biomaterials and to assess their biological safety.Materials and Methods. To create xenodermal biomaterials, the native skin of a 4-month-old Landrace pig was used. The porcine dermis was processed with saline (protocol No.1), peroxide-alkaline (protocol No.2), and alkaline (protocol No.3) solutions. The obtained samples were stained with hematoxylin-eosin and a DAPI fluorescent dye. Quantitative DNA analysis and assessment of cytotoxicity by the LIVE/DEAD assay were also performed. Samples were implanted/injected subcutaneously to 6-month-old male Wistar rats (n=30) weighing 260±20 g and explanted on day 14 of the experiment. Histological sections were stained with hematoxylin-eosin. Computer morphometry was performed using GraphPad Prism v. 6.04.Results. Samples of surgical materials obtained according to the three protocols had different physical characteristics: dermis treated according to protocol No.1 was dense and white in color after processing; samples processed by protocol No.2 were transparent and dense, and samples treated according to protocol No.3 had transparent gel-like structures. Histological analysis has shown oxyphilicity and extracellular matrix structure loss in all samples, and DAPI staining has revealed the destruction of cell nuclei. Nevertheless, DNA amount in the samples processed according to protocol No.1 did not meet the established quality criterion for decellularization (50 ng/mg dry weight). Further cytotoxicity assessment in vitro and in vivo was carried out only for samples fabricated according to protocols No.2 and No.3. According to the LIVE/DEAD analysis, both samples were not cytotoxic. On day 14 after the subcutaneous sample implantation, no signs of suppuration and immune rejection were found in the animals. Conclusion.To obtain surgical materials in the form of bioplastic coatings, it is recommended to use alkaline-peroxide treatment of the dermis, while hydrogel coatings are produced by alkaline hydrolysis.

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Section: Introductionmentioning

confidence: 99%

Selection of the Optimal Method for Creating Various Forms of Biocompatible Xenodermal Materials

Melkonyan¹,

Y.A.²,

Verevkin³

et al. 2022

Sovrem Tehnol Med

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“…На основе хитозана и кальциевой соли альгиновой кислоты для лечения инфицированных и гнойных ран различной локализации и генеза разработаны биосовместимые гелевые формы раневых покрытий, содержащие в качестве биологически активных компонентов БАВ из морских гидробионтов (фукоидан, тинростим, моллюскам) [43][44][45][46].…”

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Biologically Active Substances from Marine Hydrobionts of the Pacific Ocean as the Basis for Developing New Medicines

Беседнова¹,

Ts²,

Кузнецова³

et al. 2021

PH&LE

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Introduction: Since 1970s, a school of thought on management of innate and acquired immunity systems using biologically active substances of the Far East marine origin has been developed by the Immunology Laboratory of Somov Research Institute of Epidemiology and Microbiology of the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor). Biopolymers, which constitute the structural basis of live marine organisms and sustain numerous vital processes, draw special attention as potential candidates for pharmaceutical forms. The objective of our study was to summarize the results of long-term research on biologically active substances (BAS) from marine aquatic organisms (hydrobionts) of the Pacific Ocean as the basis for developing medicinal preparations for infectious disease prevention and treatment and dietary supplements for food and functional food products. Methods: We have selected and analyzed 46 principal published works of the researchers of the Institute found in electronic databases (Web of Science, PubMed, and eLibrary) using appropriate keywords. Results: We established that over 500 substances from various hydrobionts of the Pacific Ocean including invertebrates, fish, algae, marine bacteria (polycationic and polyanionic polysaccharides of brown and red algae), pectins (colloidal carbohydrates of high molecular weight and complex structure), lipopolysaccharides and polysaccharides from marine proteobacteria, glycoproteins, proteoglycans, glycolipids, low-molecular compounds of marine origin (sulfated polyoxysteroids, peptides, beta-glucans, nucleic acids, amino acid complexes, naphthoquinones and spinochromes of sea urchins) had been studied for their biological properties over the past almost half a century. The studies produced abundant new data on immunomodulatory, antibacterial, antiviral, antitumor, anti-adhesive, anti-endotoxic, pro-apoptotic, hepatoprotective, and hypolipidemic properties of biologically active substances, substantiated feasibility of designing innovative BAS-based medicines, and developed environmentally safe functional food products and dietary supplements. Conclusions: Biologically active substances from marine hydrobionts are a promising source for the development of novel domestic pharmaceuticals.

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Physical and Chemical Properties of Dense Ceramics Based on a Mixture of Calcium Phosphates

Golovanova,

Tsyganova

2023

Russ. Metall.

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Biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (review of literature)

Cited by 9 publications

References 36 publications

Selection of the Optimal Method for Creating Various Forms of Biocompatible Xenodermal Materials

Selection of the Optimal Method for Creating Various Forms of Biocompatible Xenodermal Materials

Biologically Active Substances from Marine Hydrobionts of the Pacific Ocean as the Basis for Developing New Medicines

Physical and Chemical Properties of Dense Ceramics Based on a Mixture of Calcium Phosphates

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