Biocompatible and biodegradable triboelectric nanogenerators based on hyaluronic acid hydrogel film

Kim, Hyunki; Choi, Saehan; Hong, Yunhwa; Chung, Woo‐Jae; Choi, Jinsung; Choi, Woong-Ku; Park, In Woo; Park, Sang Hyeok; Park, Hyeok; Heo, Kwang; Lee, Minbaek

doi:10.1016/j.apmt.2020.100920

Cited by 36 publications

(23 citation statements)

References 44 publications

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“…Their chemical structure, molecular weight, crystal structure, and molecular interaction with CPMs have a significant influence on the mechanical stability, hydrophilicity, hydrophobicity, biocompatibility, and degradation rate of the final composite [ 53 ]. As shown in Figure 2 a, various naturally-derived polymers, such as cellulose [ 54 ], chitosan [ 55 ], alginate [ 56 ], fibroin [ 57 ], starch [ 58 ], hyaluronic acid [ 59 ], poly(glutamic acid) [ 60 ], and collagen [ 61 ], have been reported for their biodegradable characteristics. Due to their similarity of macro biomolecules, a lot of naturally-derived BFMs exhibit high biocompatibility for use as implantable temporary components in medical technology [ 62 ].…”

Section: Materials For Biodegradable Polymeric Compositesmentioning

confidence: 99%

Biodegradable Polymer Composites for Electrophysiological Signal Sensing

2022

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Electrophysiological signals are collected to characterize human health and applied in various fields, such as medicine, engineering, and pharmaceuticals. Studies of electrophysiological signals have focused on accurate signal acquisition, real-time monitoring, and signal interpretation. Furthermore, the development of electronic devices consisting of biodegradable and biocompatible materials has been attracting attention over the last decade. In this regard, this review presents a timely overview of electrophysiological signals collected with biodegradable polymer electrodes. Candidate polymers that can constitute biodegradable polymer electrodes are systemically classified by their essential properties for collecting electrophysiological signals. Moreover, electrophysiological signals, such as electrocardiograms, electromyograms, and electroencephalograms subdivided with human organs, are discussed. In addition, the evaluation of the biodegradability of various electrodes with an electrophysiology signal collection purpose is comprehensively revisited.

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Section: Materials For Biodegradable Polymeric Compositesmentioning

confidence: 99%

Biodegradable Polymer Composites for Electrophysiological Signal Sensing

2022

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“…Kim et al 73 attempted to develop a fully biodegradable TENG based on a hyaluronic acid (HA) hydrogel film and chitosan film as triboelectric layers and Mg electrodes. It was observed that the electrodes dissolved in DI water after 3 h, and the triboelectric layers after 3 days.…”

Section: Hydrogel Overviewmentioning

confidence: 99%

Hydrogel‐based triboelectric nanogenerators: Properties, performance, and applications

Torres

Troncoso

De-la-Torre

2021

Intl J of Energy Research

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Summary The development of triboelectric nanogenerators (TENGs) in 2012 revolutionized the vision of environmental energy harvesting. Nowadays, TENG assembly, working mode, and material selection are investigated continuously in order to obtain high‐performance and long‐lasting devices. Hydrogels are flexible and stretchable water‐swollen 3D polymer networks, which can be tailored to conduct electricity and render outstanding mechanical properties. Hydrogels have been used to develop novel flexible wearable TENGs. Here, we review the current knowledge concerning hydrogel‐based TENGs, including an overview of relevant hydrogel characteristics, hydrogel‐based TENG performance, and their practical applications. The single‐electrode TENG working mode is the most popular in hydrogel‐based TENGs as they can be easily attached and stretched for biomechanical energy harvesting. Hydrogel‐based TENGs have demonstrated to be capable of delivering high electrical output (250‐400 V, ≥10 μA) and being robust enough for devices that last for several months. Biomechanical energy sensing and harvesting, smart farming, biomedical, and human–machine control interfaces are investigated as potential applications of hydrogel‐based TENGs. Interestingly, energy harvesting from human motion is of particular interest for this type of TENG due to its outstanding stretchability, strength, and additional physical properties, such as self‐healing ability. In most cases, the devices are capable of powering small electronics entirely from harvested biomechanical energy. Biomedical applications involved wound healing acceleration driven by TENG‐powered electrical stimuli and disease monitoring, including implantable devices. Despite showing promising electrical performance, controlling water evaporation is still challenging to maintain the mechanical and conductive properties of hydrogel‐based TENGs. On the other hand, fully biodegradable TENGs are largely unexplored, as well as many applications, such as blue energy harvesting, the internet of things, and others. The next steps in this line of research must focus on addressing the main challenges of hydrogel‐based TENGs and filling the application knowledge gaps.

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“…Recovery of full-thickness skin wounds of different shapes can be facilitated using medicated bionic microneedle patches. Only recently, the electrical communication with tissues has attracted researcher’s attention. − Triboelectrical − or piezoelectrical ,− nanogenerators are increasingly explored for providing the electrical information beneficial for tissue repair. However, the delicate integration of the electrical and chemical components in multifunctional and user-friendly biomaterials is still challenging.…”

Section: Introductionmentioning

confidence: 99%

Effective Scald Wound Functional Recovery Patch Achieved by Molecularly Intertwined Electrical and Chemical Message in Self-Adhesive Assemblies

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Bioactive materials that communicate with biotissues via simultaneous chemical and electrical information promise an advanced medical treatment strategy. Rational design of simultaneous chemically and electrically active materials is still challenging. In this study, we develop a bioactive wound healing patch that enables functional recovery of scald skin wounds by integrating electrically and chemically active units at the molecular level. The patch should be used with massages for 10 min daily during the recovery process. This healing patch consists of a closely intertwined piezoelectric poly(vinylidene fluoride-cohexafluoropropylene) (PVDF) film and a self-adhesive poly(N,Ndimethylacrylamide) (PDMAA) hydrogel layer, which permits itself to adhere on skin wounds reversibly. Frequency-dependent electrical and chemical dose delivery is achieved in response to mechanical stimuli via the electrical−chemical crosstalk within the healing patch. Animal scald experiments show that the patch can effectively guide the functional recovery of grade I and shallow grade II scald wounds, promoting proper collagen deposition and hair follicle, blood vessel, and gland regeneration. Integrating electrically and chemically active units at the molecular level in treatment devices provides a new design concept for tissue engineering and medical treatment materials.

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Biocompatible and biodegradable triboelectric nanogenerators based on hyaluronic acid hydrogel film

Cited by 36 publications

References 44 publications

Biodegradable Polymer Composites for Electrophysiological Signal Sensing

Biodegradable Polymer Composites for Electrophysiological Signal Sensing

Hydrogel‐based triboelectric nanogenerators: Properties, performance, and applications

Effective Scald Wound Functional Recovery Patch Achieved by Molecularly Intertwined Electrical and Chemical Message in Self-Adhesive Assemblies

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