Biocompatible and bioactive gum Arabic coated iron oxide magnetic nanoparticles

Roque, Ana C. A.; Bicho, A.; Batalha, Íris L.; Cardoso, Ana Sofia; Hussain, Abid

doi:10.1016/j.jbiotec.2009.08.020

Cited by 84 publications

(55 citation statements)

References 31 publications

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“…The particles to each GA was added after the co-precipitation of magnetite yielded lower hydrodynamic diameters, showing the dispersing effect of GA. FTIR analysis on the samples confirmed the presence of GA on the MNP surface. Previously analysis (Roque et al, 2009) showed that the amount of GA bound to the MNPs by the different coating methods yielded about 1 g GA/g support. HEK293 cell cultures were grown in the presence of non-coated (MNP) or coated particles (MNP_GA ADS , MNP_GA APTS and MNP_GA EDC ).…”

Section: Resultsmentioning

confidence: 99%

“…GA (40 mg/ml) was adsorbed on to the surface of MNPs (MNP_GA ADS ) as described elsewhere (Roque et al, 2009). GA (40 mg/ml) was also covalently bound to the MNPs modified by two different routes: (i) glutaraldehyde-activated MNPs reacted with GA via their free amine groups (MNP_GA APTS ) and (ii) amine-modified MNPs reacted with GA via their free carboxyl groups through EDC reaction (MNP_GA EDC ) (Roque et al, 2009). All particles were characterized by dynamic light scattering, Fourier transformed infrared spectroscopy and transmission electron microscopy.…”

Section: Synthesis and Modification Of Mnpsmentioning

confidence: 99%

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In vitro studies with mammalian cell lines and gum arabic‐coated magnetic nanoparticles

Bicho

Roque

Cardoso

et al. 2010

J of Molecular Recognition

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Iron oxide magnetic nanoparticles (MNPs) were synthesized by the chemical co-precipitation method and coated with gum arabic (GA) by physical adsorption and covalent attachment. Cultures of mammalian cell lines (HEK293, CHO and TE671) were grown in the presence of uncoated and GA-coated MNPs. Cellular growth was followed by optical microscopy in order to assess the proportion of cells with particles, alterations in cellular density and the presence of debris. The in vitro assays demonstrated that cells from different origins are affected differently by the presence of the nanoparticles. Also, the methods followed for GA coating of MNPs endow distinct surface characteristics that probably underlie the observed differences when in contact with the cells. In general, the nanoparticles to which the GA was adsorbed had a smaller ability to attach to the cells' surface and to compromise the viability of the cultures.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Modification Of Mnpsmentioning

confidence: 99%

In vitro studies with mammalian cell lines and gum arabic‐coated magnetic nanoparticles

Bicho

Roque

Cardoso

et al. 2010

J of Molecular Recognition

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“…The pH value of the native gum arabic solution was 4.58, and its isoelectric point was 1.8. At this point, the carboxylic and amino groups carry negative and positive charges, respectively [60]. The carboxylic groups become fully protonated and less hydrophilic in acidic media at pH < pKa, whereas at pH > pKa, the carboxylic groups become ionized and have lower hydrophobicity.…”

Section: Discussionmentioning

confidence: 99%

Formation and Stabilization of Vaterite Calcium Carbonate by Using Natural Polysaccharide

Saraya¹,

Rokbaa²

2017

ANP

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This paper aimed to study the effects of natural polysaccharide (gum arabic, GA) on the formation of vaterite calcium carbonate and its stability in aqueous solution. Gum arabic is a macromolecule that has a high molecular weight and is amphoteric in character. A 0, 2.5, 5 or 10 ml of GA solution (30%) was added to the calcium chloride solution with various initial concentrations to prepare the vaterite calcium carbonate. The calcium carbonate particles were characterized using FTIR, XRD, SEM, TEM and DSC-TG as well as calculation of phase contents. The results of XRD and FTIR analysis were showing that the presence of GA during the precipitation changes the behavior of calcium carbonate to form vaterite until at lower dose used. In addition, the molar content of vaterite increased at the expense of content of calcite with increasing the GA dose. There are slightly improvements in the vaterite content by increasing the initial concentration. The formed vaterite calcium carbonates composed of aggregates as broccoli-like or spherical shape and with particle size 1.6 -2.5 µm in diameter. TEM images showed that these aggregates composed of the sub spherical unit with diameter 15 -30 nm. The thermal behavior of prepared vaterite was conformed the mineral composition of these phases. The prepared calcium carbonate, which is formed in the presence of different doses of gum, has a stability in the aqueous solutions at different temperatures, as the analyzes indicated that a very small percentage of the vaterite were converted to calcite. The gum arabic prevented or depressed the transformation of vaterite to calcite through capped the surface of particles, i.e. it is more effective in stabilizing the vaterite phase with increasing in initial concentration and time.

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“…Commercially, GA is being used as stabilizer, thickening agent and hydrocolloid emulsifier. Recently, the use of GA has been extended to nanotechnology due to its stabilizing nature of nanostructures; it has been probed for the coating over iron oxide (Roque et al 2009) and gold (Kannan et al 2006) nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gum arabic on distribution behavior of nanocellulose fillers in starch film

Vigneshwaran

Ammayappan

2011

Appl Nanosci

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Uniform distribution of nanofillers in polymer matrix is posing a major challenge in exploiting the full potential of nanomaterials. Various fillers are being evaluated to improve the performance of biopolymer films like starch. In this work, nanocellulose is used as fillers to increase the performance characteristics of starch film. Due to high surface energy and hydrophilic nature of nanocellulose, they tend to aggregate during the film forming process. To circumvent this problem, Gum arabic (GA) was added to distribute the nanocellulose uniformly. GA helps in reduction of surface energy (as analyzed by contact angle) and thus facilitates the uniform distribution of nanocellulose (as demonstrated through polarized light microscopy). Nanocellulose as filler improved the tensile strength of starch film by 2.5 times while that of uniformly distributed nanocellulose by 3.5 times. Moreover, while nanocellulose as such could reduce the water vapor permeability of starch film by 1.4 times, uniformly distributed nanocellulose reduced it by 2 times proving the importance of GA. Starch film filled with nanocellulose and GA will be a 100% biopolymer-based system having potential demand in eco-friendly applications.

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Biocompatible and bioactive gum Arabic coated iron oxide magnetic nanoparticles

Cited by 84 publications

References 31 publications

In vitro studies with mammalian cell lines and gum arabic‐coated magnetic nanoparticles

In vitro studies with mammalian cell lines and gum arabic‐coated magnetic nanoparticles

Formation and Stabilization of Vaterite Calcium Carbonate by Using Natural Polysaccharide

Effect of Gum arabic on distribution behavior of nanocellulose fillers in starch film

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