Biocompatibility Testing of Branched and Linear Polyglycidol

Kainthan, Rajesh K.; Janzen, Johan; Levin, E.J.; Devine, Dana V.; Brooks, Donald E.

doi:10.1021/bm0504882

Cited by 371 publications

(365 citation statements)

References 28 publications

(55 reference statements)

Supporting

Mentioning

344

Contrasting

Unclassified

Order By: Relevance

“…[8][9][10][11] Similar to PEO, the polyglycidol is also biocompatible. 12 The hydroxyl groups introduced to polyether-polyester block copolymers open new possibilities for further functionalizations. On the other hand, the synthesis of the polyglycidol block requires protection-deprotection reactions which can destroy the sensitive polyester block.…”

Section: Introductionmentioning

confidence: 99%

Selective cleavage of acetal bonds in copolymers with polylactide block

Sosnowski

2008

J. Polym. Sci. A Polym. Chem.

View full text Add to dashboard Cite

A polyester‐polyether copolymer containing hydroxyls protected by 1‐ethoxyethyl groups was subjected to the reaction of acetal cleavage. It was found that under mild conditions: room temperature, 10‐fold excess of methanol, and 1 mol% of AlCl3·6H2O as catalyst, reaction time equal 1 hour, the reaction is quantitative and selective toward acetal groups and not harmful to the ester bonds. The molecular weight of the copolymer was equal to expected one and did not change during threefold prolongation of time of the reaction.

show abstract

Section: Introductionmentioning

confidence: 99%

Selective cleavage of acetal bonds in copolymers with polylactide block

Sosnowski

2008

J. Polym. Sci. A Polym. Chem.

View full text Add to dashboard Cite

show abstract

“…These unique macromolecules are highly biocompatible and can present multiple functionalities on their surface (16). In contrast to biological macromolecules, a very high number of functional groups can interact with the respective binding region, which results in a significant increase of binding affinity.…”

mentioning

confidence: 99%

Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation

Dernedde

Rausch

Weinhart

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

247

294

View full text Add to dashboard Cite

Adhesive interactions of leukocytes and endothelial cells initiate leukocyte migration to inflamed tissue and are important for immune surveillance. Acute and chronic inflammatory diseases show a dysregulated immune response and result in a massive efflux of leukocytes that contributes to further tissue damage. Therefore, targeting leukocyte trafficking may provide a potent form of antiinflammatory therapy. Leukocyte migration is initiated by interactions of the cell adhesion molecules E-, L-, and P-selectin and their corresponding carbohydrate ligands. Compounds that efficiently address these interactions are therefore of high therapeutic interest. Based on this rationale we investigated synthetic dendritic polyglycerol sulfates (dPGS) as macromolecular inhibitors that operate via a multivalent binding mechanism mimicking naturally occurring ligands. dPGS inhibited both leukocytic L-selectin and endothelial P-selectin with high efficacy. Size and degree of sulfation of the polymer core determined selectin binding affinity. Administration of dPGS in a contact dermatitis mouse model dampened leukocyte extravasation as effectively as glucocorticoids did and edema formation was significantly reduced. In addition, dPGS interacted with the complement factors C3 and C5 as was shown in vitro and reduced C5a levels in a mouse model of complement activation. Thus, dPGS represent an innovative class of a fully synthetic polymer therapeutics that may be used for the treatment of inflammatory diseases.anti-inflammatory drug | complement inhibition | multiple target binding | multivalent selectin inhibitor | synthetic polymer

show abstract

“…injection at a dose of 1 g kg À1 . 117 Also very high molecular weight hyperbranched PG (up to 700 kDa) appears to have little effect on the biocompatibility in vitro for blood compatibility, viscosity, complement activation, platelet activation, plasma protein precipitation, and cytotoxicity. 118 Although the biocompatibility of polymers in general is a function of molecular weight, the inherently compact hyperbranched structure appears to remove many of the disadvantages associated with the exposure of high molecular weight linear polymers to blood and cells: in solution, hbPG s behave more like proteins than linear polymers.…”

Section: Biocompatibilitymentioning

confidence: 97%

Hyperbranched aliphatic polyether polyols

Schömer

Schüll

Frey

2012

J. Polym. Sci. A Polym. Chem.

View full text Add to dashboard Cite

Hyperbranched polymers, dendritic macromolecules with branch-on-branch structures, have become an important polymer class since the early 1990s. They combine several advantages of the perfectly branched dendrimers with easy accessibility, typically in a one-step synthesis. Hyperbranched polyethers are a particularly interesting class of chemically stable and often biocompatible materials. Multifunctional hyperbranched polyethers with controllable molar mass and comparably low polydispersities can been prepared using hydroxyl-functional epoxides or oxetanes for polymerization via anionic and cationic polymerization mechanisms. Here, we review the progress in the preparation, characterization, and application of these uniquely versatile aliphatic polyether polyols. Their unusual mechanical, thermal, and solution properties render them useful for a variety of applications, for example, as building blocks for various complex macromolecular architectures or in biomedical applications.

show abstract

Biocompatibility Testing of Branched and Linear Polyglycidol

Cited by 371 publications

References 28 publications

Selective cleavage of acetal bonds in copolymers with polylactide block

Selective cleavage of acetal bonds in copolymers with polylactide block

Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation

Hyperbranched aliphatic polyether polyols

Contact Info

Product

Resources

About