Biocompatibility study of poly(vinyl alcohol)-based electrospun scaffold for hernia repair

Molnár, Kristóf; Voniatis, Constantinos; Fehér, D.; Ferencz, Andrea; Fónyad, László; Reiniger, Lilla; Zrı́nyi, Miklós; Wéber, György; Jedlovszky-Hajdú, Angéla

doi:10.3144/expresspolymlett.2018.58

Cited by 17 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, in controlled drug release applications, encapsulation enhances and prolongs the effectiveness of active ingredients, while in drug targeting, polymeric-based particles can be used as carriers for the targeted delivery of the drug to a specific site of action [4]. One class of the wide range of applied materials are the polymers like polystyrene (PS), N-Isopropylacrylamide (NIPAM) and PLA/PLGA [5,6]. The excellent biocompatibility, low cost and good material properties of PLA would open many applications in the medical field, such as drug delivery systems [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles

Varga

Hornok

Janovák

et al. 2019

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles

Varga

Hornok

Janovák

et al. 2019

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…Various PCL-based electrospun fibers for hernia applications have previously been presented 49 , 50 , for instance, drug-loaded nanofibers with the antibiotic levofloxacin and antibacterial agent irgasan for the prevention of potential bacterial infections 38 . Nevertheless, this approach might promote the prevalence of multiantibiotic resistant organisms 51 .…”

Section: Resultsmentioning

confidence: 99%

Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

et al. 2021

View full text Add to dashboard Cite

The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.

show abstract

“…To evaluate the suture retention capacity, knots were sewed into the bioscaffold‐8 with surgical sutures and a stress–strain test was performed until the sutures tore through the bioscaffold. [ 35 ] This study revealed that the bioscaffold‐8 could retain the sutures for up to 100 kPa without failure, which is ≈5 times that of the maximum intra‐abdominal pressure (20 kPa) developed in healthy individuals (Figure 2G). These studies have demonstrated the tunability of elastic modulus and suture holding capacity of the bioscaffold by optimizing the number of printed layers in the bioscaffold.…”

Section: Figurementioning

confidence: 91%

3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair

et al. 2020

View full text Add to dashboard Cite

creates a defect that intra-abdominal contents may protrude through. [1] The most common types of hernias are incisional, inguinal, femoral, umbilical and hiatal hernias. [2] Hernia repair for many defects is performed by the surgical implantation of a prosthetic mesh to firmly support and reinforce the damaged abdominal wall and facilitate the healing process (Figure 1A,B). Each year, over 400 000 incisional hernia repair surgeries are performed with a cost of ≈$15 billion in US healthcare expenditures. [3-5] Prosthetic hernia mesh implants are developed using synthetic, biologic, and coated materials. [6,7] Despite their specific advantages, these mesh implants are not very effective in minimizing potential adverse postsurgical complications. [8] Surgical hernia repair with mesh implants mostly fail due to the formation of visceral adhesions, hardening, and shrinking of the mesh after its implantation. Visceral adhesions are fibrous tissues developed from the underlying serosal membrane of stomach, intestine or colon, that attach to the implanted mesh. [9] These adhesions are mainly composed of collagen and fibroblasts that grow on the mesh and adhere to the nearby tissue, nerves and organs. [10] The mesh shrinks as the adhesions grow and scar tissue hardens, thus forming a hard, fibrous mass that may cause chronic pain, bowel obstruction, enteric fistula, infertility, poor quality of life, and failure of the surgical hernia repair. [11-13] To remove the failed hernia mesh, a complicated surgery needs to be performed, wherein the mesh must be peeled off bladder, stomach, intestine, colon, or a major blood vessel, that may adversely affect the clinical outcomes. [14] To minimize adhesions formation, graft contraction, and foreign body reactions, absorbable and biological meshes have been developed. However, these meshes are not significantly effective because of very high hernia recurrence rates. [15-17] Causative factors for adverse complications arising due to surgical mesh implantation are chronic inflammatory responses, poor mesh-tissue integration, rapid degradation of the materials, surface chemistry and topochemical design of the mesh. [18,19] We herein present the development of an intrinsically inflammation modulating 3D-fabricated biomaterial scaffold (bioscaffold) for soft tissue repair and demonstrate its in vivo efficacy in a rat ventral hernia Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard of care soft tissue repair meshes for hernia repair is highly inflammatory and initiates a dysregulated inflammatory process causing visceral adhesions and postsurgical complications. Herein, the development of an inflammation modulating biomaterial scaffold (bioscaffold) for soft tissue repair is presented. The bioscaffold design is based on the idea that, if the excess proinflammatory cytokines are sequestered from the site of injury by the surgical implantation of a bioscaffold,...

show abstract

Biocompatibility study of poly(vinyl alcohol)-based electrospun scaffold for hernia repair

Cited by 17 publications

References 0 publications

The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles

The effect of synthesis conditions and tunable hydrophilicity on the drug encapsulation capability of PLA and PLGA nanoparticles

Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair

Contact Info

Product

Resources

About