Biocompatibility studies of human fetal osteoblast cells cultured on gamma titanium aluminide

Rivera-Denizard, Omayra; Diffoot-Carlo, N.; Navas, Vivian; Sundaram, P.A.

doi:10.1007/s10856-006-0039-4

Cited by 32 publications

(20 citation statements)

References 31 publications

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“…Based on previous results [23] in which no significant differences in cell attachment and growth on Ti alloys with varying surface roughness were observed, all samples were mechanically ground using 600 grit silicon carbide paper. After surface preparation, the samples were subjected to a rigorous cleaning procedure in order to avoid contamination.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical characterization of MC3T3-E1 cells cultured on γTiAl and Ti–6Al–4V alloys

Bueno-Vera

Torres-Zapata

Sundaram

et al. 2015

Bioelectrochemistry

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Electrochemical Impedance Spectroscopy (EIS) was used to study the behavior of MC3T3-E1cells cultured in αMEM+FBS solution on two Ti-based alloys (Ti-6Al-4V and γTiAl) during 4, 7 and 14 days. EIS measurements were carried out at the open-circuit potential in the 1 mHz to 100 kHz frequency range. Results indicate a general increase in impedance on the Ti alloy surfaces with cells as a function of time. Bode plots indicate changes corresponding to the passive oxide film, adsorption of proteins and cell tissue on surfaces with the passage of time. Normal cellular activity based on the polygonal morphology, with long and fine cytoplasmic prolongations of the cells on Ti-6Al-4V and γTiAl was observed from SEM images. Similarly, mineralization nodules corresponding to cell differentiation associated with the osseogenetic process were observed confirmed by Alizarin Red S staining. Immunofluorescence analysis to detect the presence of collagen Type I showed an increase in the segregation of collagen as a function of time. The impedance values obtained from EIS testing are indicative of the corrosion protection offered to the Ti alloy substrates by the cell layer. This study shows that γTiAl has better corrosion resistance than Ti-6Al-4V in the αMEM+FBS environment in the presence of MC3T3-E1 cells.

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Section: Methodsmentioning

confidence: 99%

Electrochemical characterization of MC3T3-E1 cells cultured on γTiAl and Ti–6Al–4V alloys

Bueno-Vera

Torres-Zapata

Sundaram

et al. 2015

Bioelectrochemistry

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“…Rivera-Denizard et al argued that γ-TiAl has certain advantages over Ti-6Al-4V as a bio-implant material [14]. For instance, γ-TiAl does not contain vanadium, a toxic element; aluminum oxide, the predominant oxide of γ-TiAl, might prove better than titanium oxide, which erodes easily.…”

Section: Introductionmentioning

confidence: 99%

Porous γ-TiAl Structures Fabricated by Electron Beam Melting Process

Mohammad

Al‐Ahmari

Moiduddin

et al. 2016

Metals

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Porous metal structures have many benefits over fully dense structures for use in bio-implants. The designs of porous structures can be made more sophisticated by altering their pore volume and strut orientation. Porous structures made from biocompatible materials such as titanium and its alloys can be produced using electron-beam melting, and recent reports have shown the biocompatibility of titanium aluminide (γ-TiAl). In the present work, we produced porous γ-TiAl structures by electron-beam melting, incorporating varying pore volumes. To achieve this, the individual pore dimensions were kept constant, and only the strut thickness was altered. Thus, for the highest pore volume of~77%, the struts had to be as thin as half a millimeter. To accomplish such fine struts, we used various beam currents and scan strategies. Microscopy showed that selecting a proper scan strategy was most important in producing these fine struts. Microcomputed tomography revealed no major gaps in the struts, and the fine struts displayed compressive stiffness similar to that of natural bone. The characteristics of these highly-porous structures suggest their promise for use in bio-implants.

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“…A titanium-based alloy which is being currently studied for possible implant application is Ti-48Al-2Nb-2Cr (at. %) [17][18][19] . Oxidation of this alloy (henceforth also referred to as gamma-TiAl) at 500°C and 800°C has shown contrasting behavior in terms of cytotoxicity of the oxidized surfaces [20] .…”

Section: Introductionmentioning

confidence: 99%

Wear behavior of oxidized Ti-48Al-2Cr-2Nb (at. %), Ti-6Al-4V and Cp-Ti under dry and lubricated conditions

Ramos-Saenz

Sundaram

2015

JBEI

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Gamma titanium aluminide (gamma-TiAl) is a titanium alloy which contains no vanadium and appears to have potential for biomedical applications such as joint prostheses. The tribomechanical properties of Ti-48Al-2Cr-2Nb (at. %) (gammaTiAl) subjected to oxidation in air at 500°C and 800°C were determined by standard wear tests using a hardened stainless steel (SS) pin in a linearly reciprocating mode under both dry and lubricated (Ringer's solution) media. Similar properties for CP-Ti and Ti-6Al-4V were measured for comparison. The lowest mean mass loss was obtained for oxidized gamma-TiAl alloy indicating excellent wear resistance. The dominant wear mechanism on all the Ti alloy samples was abrasion. The oxidation temperature had a minimal effect on the wear of gamma-TiAl but was significant for the other two alloys.

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Biocompatibility studies of human fetal osteoblast cells cultured on gamma titanium aluminide

Cited by 32 publications

References 31 publications

Electrochemical characterization of MC3T3-E1 cells cultured on γTiAl and Ti–6Al–4V alloys

Electrochemical characterization of MC3T3-E1 cells cultured on γTiAl and Ti–6Al–4V alloys

Porous γ-TiAl Structures Fabricated by Electron Beam Melting Process

Wear behavior of oxidized Ti-48Al-2Cr-2Nb (at. %), Ti-6Al-4V and Cp-Ti under dry and lubricated conditions

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