Biocompatibility of Ricinus comunnis polymer compared to titanium implant used in artificial hearts. Experimental study in guinea pigs

Kubrusly, Luiz Fernando; Graça, Yorgos Luiz Santos de Salles; Sucharski, Enéas Eduardo; Sobral, Ana Cristina Lira; Olandoski, Márcia; Kubrusly, Fernando Bermudez

doi:10.5935/1678-9741.20120067

Cited by 5 publications

(14 citation statements)

References 17 publications

(16 reference statements)

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“…This conclusion was supported also by Perls stain, which clearly proved hemosiderin accumulation in renal parenchyma-granules of this pigment were observed in cytoplasm of tubular epithelial cells in both experiments. Kubrusly et al showed good tolerance of titanium implant with reduced tissue reaction (25). Consecutive massive hemosiderin depositing in tubular epithelial cells may then lead even to serious renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…So far, the precise mechanisms of long-term effects of titanium on living cells and tissues have not yet been identified. Kubrusly et al showed good tolerance of titanium implant with reduced tissue reaction (25). Microscopic metal particles in the soft tissues surrounding joint arthroplasties have been shown to activate a macrophage response inducing bone resorption and increased inflammation (26); electron microscopy discovered macrophages with numerous lysosomes containing metal debris (26).…”

Section: Discussionmentioning

confidence: 99%

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Histopathology Image Analysis in Two Long‐Term Animal Experiments with Helical Flow Total Artificial Heart

Wotke

Homolka²,

Vasků

et al. 2016

Artificial Organs

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Histopathological analysis can provide important information in long-term experiments with total artificial heart (TAH). Recently, a new type of blood pump, the helical flow total artificial heart (HF-TAH) was developed. This study aimed to investigate the changes in selected vital organs in animal experiments with implanted HF-TAH. Samples from lung, liver, and kidneys from two female goats (No. 1301 and No. 1304) with implanted HF-TAH were analyzed. Tissue samples were fixed in 10% formaldehyde and 4 µm thick transverse sections were stained with hematoxylin-eosin (HE). Additional staining was done for detection of connective tissue (Masson-Goldner stain) and for detection of iron (hemosiderin) deposits (Perls stain). Sections were scanned at 100× and 500× magnification with a light microscope. Experiment no. 1301 survived 100 days (cause of termination was heavy damage of the right pump); experimental goat no.1304 survived 68 days and was sacrificed due to severe right hydrodynamic bearing malfunction. Histopathological analysis of liver samples proved signs of chronic venostasis with limited focal necrotic zones. Dilated tubules, proteinaceous material in tubular lumen, and hemosiderin deposits were detected in kidney samples. Contamination of the organs by embolized micro-particles was suspected at the autopsy after discovery of visible damage (scratches) of the pump impeller surface (made from titanium alloy) in both experiments. Sporadic deposits of foreign micro-particles (presumably titanium) were observed in most of the analyzed parenchymal organs. However, the described deposits were not in direct connection with inflammatory reactions in the analyzed tissues. Histopathological analysis showed the presence of minimal contamination of the lung, kidney, and liver tissue samples by foreign material (titanium very likely). The analysis showed only limited pathological changes, especially in liver and kidneys, which might be attributed to the influence of artificial perfusion often observed in chronic TAH experiments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathology Image Analysis in Two Long‐Term Animal Experiments with Helical Flow Total Artificial Heart

Wotke

Homolka²,

Vasků

et al. 2016

Artificial Organs

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“…As established in the previous study in the same line of research, we maintained the methodology [ 6 ] in order to obtain materials that are low-cost, abundant in nature, and with an acceptable biocompatibility profile that would ideally replace the time-honored materials in medical practice, as these are expensive and difficult to be obtained.…”

Section: Discussionmentioning

confidence: 99%

“…[ 17 ] , Ignácio et al. [ 18 ] , Silva [ 19 ] , and Kubrusly [ 6 ] , thereby opening the way to the use of this polymer in orthopedics, orthodontics, bucomaxilar surgery, neurosurgery, and cardiovascular surgery. Furthermore, the production process of Pm is very attractive, as it needs no catalysts and shows simple processability and flexibility in formulation, thereby enabling the addition of other components- in the present case, CaCO 3 - without interfering with the chemical reaction.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies in vivo with sheep were performed and proved the efficacy of the device. In 2011, Kubrusly et al [ 6 ] initiated studies with a biocompatible material of national origin for the prospective production of a lower-cost device-this marked the beginning of the studies on the use of castor oil polymer (Pm) in the production of CADs. This polymer is formed by the reaction, in equal amounts by weight, between a polyol (OH) and a castor oil prepolymer [ 7 ] .…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility of Ricinus communis polymer with addition of calcium carbonate compared to titanium. Experimental study in guinea pigs

Graça¹,

Opolski²,

Barboza³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveThe aim of the present investigation was to determine whether the difference in inflammatory tissue reaction between the Riccinus communis (castor) polymer with calcium carbonate and the titanium implant is statistically significant.MethodsThirty-two Cavia porcellus were allocated into four groups of eight animals each. We implanted the two types of materials in the retroperitoneal space of all the animals. They were euthanized at 7, 20, 30 and 40 days after surgery, and an histological study of the samples was conducted.ResultsAll implants showed characteristics of chronic inflammation regardless of the material and timepoint of evaluation. There was no statistically significant difference between Pm+CaCO3 and Ti with regard to the presence of granulation tissue, tissue congestion, histiocytes, lymphocytes, neutrophils, giant cells, and fibrosis (P> 0.05).ConclusionThe castor oil polymer plus calcium carbonate implant was not statistically different from the titanium implant regarding inflammatory tissue reaction.

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Reconstruction of the Cranial Vault Contour Using Tissue Expander and Castor Oil Prosthesis

Moraes

Afonso²,

Santos³

et al. 2017

Craniomaxillofacial Trauma & Reconstruction

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Nowadays the reconstruction of craniofacial defects can be performed with different kinds of materials, which include the bone and the so-called biomaterials, which have the advantage of not needing a surgical site donor. Among these materials, great attention is given to polymers. In this large group, current attention is focused on the castor oil polymer, since this polymer is biocompatible, low cost, and has adequate strength for reconstruction of the craniomaxillofacial complex. This study aims to report the use of a prosthetic castor oil polymer for reconstruction of extensive defect, caused by a trauma, in the temporoparietal region.

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Biocompatibility of Ricinus comunnis polymer compared to titanium implant used in artificial hearts. Experimental study in guinea pigs

Cited by 5 publications

References 17 publications

Histopathology Image Analysis in Two Long‐Term Animal Experiments with Helical Flow Total Artificial Heart

Histopathology Image Analysis in Two Long‐Term Animal Experiments with Helical Flow Total Artificial Heart

Biocompatibility of Ricinus communis polymer with addition of calcium carbonate compared to titanium. Experimental study in guinea pigs

Reconstruction of the Cranial Vault Contour Using Tissue Expander and Castor Oil Prosthesis

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