Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal

Willbold, Elmar; Kalla, Katharina; Bartsch, Ivonne; Bobe, Katharina; Brauneis, Maria; Remennik, Sergei; Shechtman, D.; Nellesen, J.; Tillmann, Wolfgang; Vogt, Carsten; Witte, Frank

doi:10.1016/j.actbio.2013.02.015

Cited by 84 publications

(75 citation statements)

References 27 publications

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“…87 Numerous in vitro and in vivo studies have demonstrated the 88 biocompatibility and osteoconductivity of these materials. Indirect 89 assays, in which cells are exposed to media treated with Mg such as guinea pig [16], rat [17], and rabbit femora [18] 16,19,20]. 100 These data support the use of Mg implants as orthopedic 101 devices; however there remains a lack of in vivo data assessing the-102 se materials as actual fixation plates and screws.…”

Section: Introductionmentioning

confidence: 94%

In vivo study of magnesium plate and screw degradation and bone fracture healing

et al. 2015

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Section: Introductionmentioning

confidence: 94%

In vivo study of magnesium plate and screw degradation and bone fracture healing

et al. 2015

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“…Samples were implanted (i) into the medial femur (bone), (ii) under the skin of the back (subcutaneous) and (iii) into the lumbar musculature (intramuscular). The corrosion rates for various time points are presented in Table 8 [128]. After 1 week, the corrosion rates of the subcutaneous and intramuscular samples were quite similar (5.70 and 5.34 mm y −1 , respectively), and both substantially higher than the samples implanted into bone (1.65 mm y −1 ).…”

Section: Consideration For Selecting An Appropriate In Vivo Modelmentioning

confidence: 83%

“…Willbold et al [128] explored the influence of implant site on the corrosion of RS66 samples in New Zealand white rabbits. Samples were implanted (i) into the medial femur (bone), (ii) under the skin of the back (subcutaneous) and (iii) into the lumbar musculature (intramuscular).…”

Section: Consideration For Selecting An Appropriate In Vivo Modelmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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“…[1][2][3][4] Unlike titanium and stainless steel, Mg is resorbable, allowing it to be used in nonretrieving orthopedic implants, where tensile, shear, and compressive loads are low. In addition, Mg implants do not pose the problems of stress shielding, permanent physical irritation, and chronic inflammatory local reactions, which permanent metallic implants do.…”

Section: Introductionmentioning

confidence: 99%

Bioeffects of micron‐size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro

Guo

She

et al. 2015

J Biomed Mater Res

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Magnesium (Mg) is a promising biodegradable metal offering many potential advantages over current scaffold technologies. Many studies have reported on the corrosion characteristics the Mg and its bioeffects in vitro and in vivo, but there are few studies on the biological effects of the corrosive products of Mg - the micron-size Mg particles (MgMPs). In this study, the effects of size-selected commercial MgMPs on bone turnover and macrophages were investigated in vivo and in vitro. We found that MgMPs were susceptible to engulfment by macrophages, leading to cell lysis, likely resulting from H2 gas production. We also found that the inflammatory cytokines IL-1, IL-6, and TNF-α were induced more strongly by titanium particles (TiMPs) group than by either MgMPs or control. Examination of the expression of bone remodeling markers revealed that MgMPs are beneficial for bone regeneration. Micro-CT scanning indicated that, 30 days postimplantation, unlike TiMPs, MgMPs had no adverse effect on either bone quality or quantity. We have investigated the bioeffects of micron-size MgMPs in vivo and in vitro, and our results indicate that MgMPs may promote bone regeneration without inducing inflammation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 923-931, 2016.

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Biocompatibility of rapidly solidified magnesium alloy RS66 as a temporary biodegradable metal

Cited by 84 publications

References 27 publications

In vivo study of magnesium plate and screw degradation and bone fracture healing

In vivo study of magnesium plate and screw degradation and bone fracture healing

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Bioeffects of micron‐size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro

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