Biocompatibility of Polylactic Acid as a Bone Substitute: An In Vitro Study

Meenapriya, M

doi:10.21786/bbrc/13.8/144

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Studies show promising results for alloplastic substitutes as successful bone substitutes for enhanced regenerative properties. PLGA bio-polymers have been instrumental in applications in tissue engineering [12][13][14][15]. Many challenges faced in this research include potential risks like immunogenicity, toxicity, and prone to infections.…”

Section: Introductionmentioning

confidence: 99%

Maxillofacial Reconstruction With Three Dimensional Resin Bone Substitutes as an Alternative to Transition Group of Metals: A Structured Review

Rajaraman,

Ariga

et al. 2024

Cureus

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In recent years, novel technologies and techniques have allowed today the production of controlled architecture materials. Although autogenous bone graft substitutes remain the gold standard, enormous defects require supplementary alloplastic substitutes for reconstruction. Polymers have lately been explored for the same purpose and their biological performance has been under research since the last decade. The aim of this review is to analyse maxillofacial reconstruction with three-dimensional resin bone substitutes. A Problem Intervention Comparison Outcomes (PICO) analysis was done and a search was carried out in the Cochrane Database, PubMed, Google Scholar etc databases and a hand search was done to collect the related literature. All articles for maxillofacial reconstruction with three-dimensional resin bone substitutes were scrutinised. The manuscripts published from 1990 till May 2021, were included in this review. A total of 106 articles were obtained from a PICO-based keyword search, and 91 manuscripts were retrieved after excluding the duplicates. Out of these 57 manuscripts were excluded on the basis of title and abstract. From the remaining 34 studies, 17 were excluded after reading the full text based on the inclusion and exclusion criteria. During data extraction, four studies were removed and finally, 13 studies were included in this research. From this scoping review, we could conclude that polymethylmethacrylate and polylactic acid formulations are very promising resin bone substitutes for 3-dimensional reconstruction of maxillofacial defects. However, rigorous long-term clinical trials are needed to validate this conclusion.

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Section: Introductionmentioning

confidence: 99%

Maxillofacial Reconstruction With Three Dimensional Resin Bone Substitutes as an Alternative to Transition Group of Metals: A Structured Review

Rajaraman,

Ariga

et al. 2024

Cureus

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Adoption of Composite Bone Scaffold Loaded with Osteoporosis Drugs in the Repair of Bone Defects in an Osteoporotic Animal Model

Tang,

Xue,

Yue

et al. 2023

sci adv mater

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To promote the differentiation of mesenchymal stem cells (MSCs) into osteogenic lineages, icariin (ICA) was utilized. A composite scaffold material of ICA-bone powder/poly lactic acid (PLA) was constructed using biotechnology, and its therapeutic effects on osteoporotic bone defects were visualized. During the experiment, the physicochemical properties and biocompatibility of the material were analyzed, and a rat model of osteoporotic bone defects was constructed. The prepared material was implanted into the osteoporotic bone defect region, and according to the drug-loading amount (10−5 M, 10−6 M, and 10−7 M), the experimental rats were assigned into three groups (group A, group B and group C) to verify its bone defect repair performance. The results revealed that the porosity and pore size of bone powder/PLA material were (91.75±2.36)% and (213.42±16.37) μm, respectively. The addition of the Chinese herbal medicine caused a decrease in the porosity of the ICA-bone powder/PLA material, but it still exceeded 85%. After 48 h of co-culturing with human adipose-derived stem cells (hADSCs) using various drug loading amounts (10−5 M, 10−6 M, and 10−7 M) of the composite bone scaffold material, no obvious cell death was visualized. After 7 days of co-culturing, ALP staining showed that the cells grown on the prepared material surface secreted a large amount of extracellular matrix. In particular, the composite bone scaffold material with a loading amount of 10−7 M demonstrated strong positive ALP staining. The repair progress of group C rats was faster at 4 weeks and 8 weeks after surgery versus group A and group B (P < 0.05). According to ALP expression analysis, at 4 weeks after surgery, group C rats had higher ALP positive expression versus group A and group B rats (P < 0.05), and at 8 weeks after surgery, group B and group C rats had higher ALP positive expression versus group A rats (P < 0.05). These findings demonstrated that the bone powder/PLA material loaded with ICA has favorable adoption value in the repair of osteoporotic bone defects.

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Biological Characteristics of Polyurethane-Based Bone-Replacement Materials

et al. 2023

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A study is presented on four polymers of the polyurethane family, obtained using a two-stage process. The first composition is the basic polymer; the others differ from it by the presence of a variety of fillers, introduced to provide radiopacity. The fillers used were 15% bismuth oxide (Composition 2), 15% tantalum pentoxide (Composition 3), or 15% zirconium oxide (Composition 4). Using a test culture of human fibroblasts enabled the level of cytotoxicity of the compositions to be determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, along with variations in the characteristics of the cells resulting from their culture directly on the specimens. The condition of cells on the surfaces of the specimens was assessed using fluorescence microscopy. It was shown that introducing 15% bismuth, tantalum, or zinc compounds as fillers produced a range of effects on the biological characteristics of the compositions. With the different fillers, the levels of toxicity differed and the cells’ proliferative activity or adhesion was affected. However, in general, all the studied compositions may be considered cytocompatible in respect of their biological characteristics and are promising for further development as bases for bone-substituting materials. The results obtained also open up prospects for further investigations of polyurethane compounds.

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Biocompatibility of Polylactic Acid as a Bone Substitute: An In Vitro Study

Cited by 3 publications

References 22 publications

Maxillofacial Reconstruction With Three Dimensional Resin Bone Substitutes as an Alternative to Transition Group of Metals: A Structured Review

Maxillofacial Reconstruction With Three Dimensional Resin Bone Substitutes as an Alternative to Transition Group of Metals: A Structured Review

Adoption of Composite Bone Scaffold Loaded with Osteoporosis Drugs in the Repair of Bone Defects in an Osteoporotic Animal Model

Biological Characteristics of Polyurethane-Based Bone-Replacement Materials

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