Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo

Sevostyanov, M. A.; Nasakina, E. O.; Баикин, А. С.; Sergienko, K. V.; Konushkin, S. V.; Kaplan, M. A.; Seregin, Alexey; Леонов, А. В.; Козлов, В. А.; Shkirin, A. V.; Bunkin, N. F.; Колмаков, А. Г.; Simakov, S. V.; Gudkov, Sergey V.

doi:10.1007/s10856-018-6039-3

Cited by 41 publications

(15 citation statements)

References 55 publications

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“…Ni ions gradually accumulated in cells also affect the ability of bone morphogenetic protein (BMP-2) to induce alkaline phosphatase (ALP) formation [58,59]. Some studies have shown that compared with Nitinol, the surface layer rich in Ti or Ta can significantly reduce the formation of ROS and longevity protein free radicals [60]. Qiao et al found that among the concentrations of metal ions causing DNA damage in vitro, Cr(III), Fe(II) and Al(III) were 50 μM, while Ni(II) 10uM could cause DNA damage, so different metal ions with the same concentration had different toxic effects on cells [61].…”

Section: Different Metal Ions Can Induce Cell Damagementioning

confidence: 99%

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Li¹,

Yao²,

Zhang³

et al. 2020

SN Appl. Sci.

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Repair, reconstruction, and replacement of congenital malformations, either in case of exogenous or iatrogenic tissue and organ defects, requires utilization of a large number of personalized biomaterials. In recent decades, the improvement of people's quality of life and the prolongation of life expectancy have promoted the development of medical and material science. In addition to the traditionally used stainless steel, other materials such as cobalt-chromium alloy, pure titanium, titanium alloy, and the newly alloy materials continue to emerge, such as tantalum-based alloy materials which have been used in clinic, especially the application of porous tantalum trabecular metal in orthopedics. This paper which has provided good preliminary works for the development of tantalum biomaterials with more advantages in the future such as tantalum dental implants summarizes in detail the progress of tantalum materials in physicochemical properties and biocompatibility in recent years. From the comparison of surface passivation films of different metals in different environments, the electrochemical corrosion behavior of tantalum, the release of different metal ions and the damage to cells, it is concluded that tantalum has excellent corrosion resistance. Besides, the excellent biocompatibility of tantalum metals concluded by cytology, molecular biology, protein adsorption experiment, and hematology experiment, as well as regular follow-up observation of patients with porous tantalum trabecular metal in clinic. The excellent corrosion resistance and biocompatibility of the tantalum metal have a very wide prospect in clinical application.

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Section: Different Metal Ions Can Induce Cell Damagementioning

confidence: 99%

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Li¹,

Yao²,

Zhang³

et al. 2020

SN Appl. Sci.

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“…The surgery was carried out under Zoletil/xylazine anesthesia (6/12 mg per 1 kg of body weight). The operated animals were sacrificed 60 days after the implantation [25].…”

Section: Implantation Testsmentioning

confidence: 99%

Polylactide-Based Stent Coatings: Biodegradable Polymeric Coatings Capable of Maintaining Sustained Release of the Thrombolytic Enzyme Prourokinase

et al. 2019

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The novelty of the study is the development, creation, and investigation of biodegradable polymeric membranes based on polylactide, that are capable of directed release of large molecular weight biomolecules, particularly, prourokinase protein (MW = 46 kDa). Prourokinase is a medication with significant thrombolytic activity. The created membranes possess the required mechanical properties (relative extension value from 2% to 10%, tensile strength from 40 to 85 MPa). The membranes are biodegradable, but in the absence of living cells in a water solution they decompose by less than 10% in half a year. The created membranes are capable of controlled prourokinase release into intercellular space, and the total enzymatic activity of prourokinase does not decrease by more than 12%. The daily release of prourokinase from one square centimeter of the membrane ranges from 1 to 40 μg per day depending on the technique of membrane preparation. The membranes have no acute toxic effect on cells accreting these surfaces de novo. The number of viable cells is at least 96%−97% of the overall cell count. The mitotic index of the cells growing on the surface of the polymeric films comprised around 1.5%. Histological examination did not reveal any disorders in tissues of the animals after the implantation of polymer membranes based on polylactide, both alone and as components of stent cover. Implantation of stents covered with prourokinase-containing polymers led to the formation of a mature connective tissue capsule that is thicker than in the case of uncovered stents. Thus, various polylactide-based biodegradable polymeric membranes possessing the required mechanical properties and capable of prolonged and directed release of prourokinase macromolecules are developed and investigated in the study.

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“…Moreover, the toxic properties of nickel and the likelihood of corrosion failure of the material (damage to the product in the environment of operation) limit their applicability [10][11][12][13][14][15][16][17]. The inhibitory effect of nickel ions on cell growth and survival [10,15] and the inflammatory effect of the nickel implant on surrounding tissues [14] have been shown.…”

Section: Introductionmentioning

confidence: 99%

Obtaining a Wire of Biocompatible Superelastic Alloy Ti–28Nb–5Zr

et al. 2020

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Using the methods of electric arc melting, intermediate heat treatments, and consecutive intensive plastic deformation, a Ti–Nb–Zr alloy wire with a diameter of 1200 μm was obtained with a homogeneous chemical and phase (β-Ti body-centered crystal lattice) composition corresponding to the presence of superelasticity and shape memory effect, corrosion resistance and biocompatibility. Perhaps the wire structure is represented by grains with a nanoscale diameter. For the wire obtained after stabilizing annealing, the proof strength Rp0.2 is 635 MPa, tensile strength is 840 MPa and Young’s modulus is 22 GPa, relative elongation is 6.76%. No toxicity was detected. The resulting wire is considered to be promising for medical use.

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Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo

Cited by 41 publications

References 55 publications

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Polylactide-Based Stent Coatings: Biodegradable Polymeric Coatings Capable of Maintaining Sustained Release of the Thrombolytic Enzyme Prourokinase

Obtaining a Wire of Biocompatible Superelastic Alloy Ti–28Nb–5Zr

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