Biocompatibility of nanostructured boron doped diamond for the attachment and proliferation of human neural stem cells

Taylor, Alice C.; Vagaska, Barbora; Edgington, Robert; Hébert, Clément; Ferretti, Patrizia; Bergonzo, P.; Jackman, Richard B.

doi:10.1088/1741-2560/12/6/066016

Cited by 40 publications

(35 citation statements)

References 49 publications

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“…Three key areas rapidly hastening the onset of effective intra-cortical BCIs include developments in: Electrodes and other implantable materials with reduced neuro-inflammatory responses, including recent advances in carbon nanotube (CNT) electrodes [16,17,18,19,20,21,22],Novel fabrications allowing much greater sensor density [23,24,25,26], andImproved wireless communication and power transmission technologies [27,28,29]. …”

Section: Introductionmentioning

confidence: 99%

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The Cluster Variation Method: A Primer for Neuroscientists

Maren

2016

Brain Sciences

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Effective Brain–Computer Interfaces (BCIs) require that the time-varying activation patterns of 2-D neural ensembles be modelled. The cluster variation method (CVM) offers a means for the characterization of 2-D local pattern distributions. This paper provides neuroscientists and BCI researchers with a CVM tutorial that will help them to understand how the CVM statistical thermodynamics formulation can model 2-D pattern distributions expressing structural and functional dynamics in the brain. The premise is that local-in-time free energy minimization works alongside neural connectivity adaptation, supporting the development and stabilization of consistent stimulus-specific responsive activation patterns. The equilibrium distribution of local patterns, or configuration variables, is defined in terms of a single interaction enthalpy parameter (h) for the case of an equiprobable distribution of bistate (neural/neural ensemble) units. Thus, either one enthalpy parameter (or two, for the case of non-equiprobable distribution) yields equilibrium configuration variable values. Modeling 2-D neural activation distribution patterns with the representational layer of a computational engine, we can thus correlate variational free energy minimization with specific configuration variable distributions. The CVM triplet configuration variables also map well to the notion of a M = 3 functional motif. This paper addresses the special case of an equiprobable unit distribution, for which an analytic solution can be found.

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Section: Introductionmentioning

confidence: 99%

“…Electrodes and other implantable materials with reduced neuro-inflammatory responses, including recent advances in carbon nanotube (CNT) electrodes [16,17,18,19,20,21,22],…”

Section: Introductionmentioning

confidence: 99%

The Cluster Variation Method: A Primer for Neuroscientists

Maren

2016

Brain Sciences

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“…All three cell lines formed dense neural networks and neurite extensions on the aminated ND substrates over long periods of culture (3 weeks). Electrically conductive ND substrates can also be obtained by boron-doping of ND [145]. Full factorial studies should be conducted in the future to gain further insight on the role of substrate topography and surface chemistry on the adhesion of both bone and neural cell lines.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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“…Hence, more robust and more biocompatible thin film materials are sought in order to induce neither immune response in tissue nor degradation over time. In this context, conductive diamond is seen as a promising electrode material because it is physically and chemically highly stable as well as biocompatible and reduced glial formation has been observed when compared with other electrode materials, thus promoting long term stability of the neural stimulation [8][9][10][11][12][13]. Also, diamond offers a quality interface with biological tissues since the development of neurons and glial cells on diamond was proven to be comparable to the one on glass substrate [14].…”

Section: Accepted Manuscriptmentioning

confidence: 99%