Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials

Grobelski, Bartłomiej; Wach, Radosław A.; Adamus, Agnieszka; Olejnik, Alicja K.; Ludwicka, Karolina; Kołodziejczyk, Marek; Bielecki, Stanisław; Rosiak, Janusz M.; Pasieka, Zbigniew

doi:10.1080/00914037.2013.854223

Cited by 13 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The composites were prepared by impregnation of the PCL acetone solution into a dried BC membrane. The BC–PCL composite membranes showed to have improved transparency (transmittance of 85%), be biocompatible and more malleable . To further evaluate the potential clinical applications of these membranes, Sepúlveda et al .…”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

124

View full text Add to dashboard Cite

Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

show abstract

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

124

View full text Add to dashboard Cite

show abstract

“…The PCL is a thermoplastic, biodegradable and biocompatible polymer (Pok et al 2010), also having viscoelasticity (Duling et al 2008). The bacterial cellulose/ polycaprolactone (BC /PCL) composite formed more malleable membranes with high transparency (transmittance 85%) when compared with pure BC membranes (Barud et al 2013) and its biocompatibility has been shown (Grobelski et al 2014). Thus, the objective of this study was to evaluate in vivo the ability of two membranes, BC/PCL and BC, in regenerating superficial corneal ulcers in rabbits with the hypothesis that these membranes are biocompatible and integrated into the cornea, favoring epithelialisation, and therefore the regeneration of experimental ulcers.…”

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose and bacterial cellulose/polycaprolactone composite as tissue substitutes in rabbits' cornea

et al. 2016

View full text Add to dashboard Cite

In order to test the performance of bacterial cellulose/polycaprolactone composite (BC/PCL) and pure bacterial cellulose (BC) as tissue substitutes in rabbits' cornea, a superficial ulcer containing 5mm in diameter and 0.2mm deep was made in the right cornea of 36 rabbits, then a interlayer pocket was created from the basis of this ulcer. Twelve rabbits received BC/PCL membrane and 12 were treated with BC membranes, both membranes with 8mm in diameter. The remaining rabbits received no membrane constituting the control group. The animals were clinically followed up for 45 days. Three animals of each group were euthanized at three, seven, 21, and 45 days after implantation for histological examination of the cornea along with the implant. Clinical observation revealed signs of moderate inflammatory process, decreasing from day 20th in the implanted groups. Histology showed absence of epithelium on the membranes, fibroplasia close to the implants, lymph inflammatory infiltrate with giant cells, collagen disorganization, with a predominance of immature collagen fibers in both groups with implants. Although inflammatory response is acceptable, the membranes used does not satisfactorily played the role of tissue substitute for the cornea during the study period.

show abstract

“…Due to the strong presence of oxygen groups, this polymer can poses a negative charge that can respond to pH changes [177]. Moreover, some polyesters can be enzymatically degraded such as in the case of polycaprolactone (PCL), polylactic acid (PLA), and polyhydroxyalkanoates (PHA), among others [178][179][180][181]. Lipases are an important group of esterases for the biodegradation of aliphatic polyesters.…”

Section: Polyestersmentioning

confidence: 99%

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

et al. 2020

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC.

show abstract

Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials

Cited by 13 publications

References 13 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Bacterial cellulose and bacterial cellulose/polycaprolactone composite as tissue substitutes in rabbits' cornea

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

Contact Info

Product

Resources

About