Biocompatibility of gold nanoparticles: In-vitro and In-vivo study

Kadhim, Rua J.; Karsh, Esraa H.; Taqi, Zainab J.; Jabir, Majid S.

doi:10.1016/j.matpr.2020.12.826

Cited by 41 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, research was conducted to develop different Au-based metal alloy nanoparticle systems (e.g., Au-Ag, Au-Pd, Au-Pt) [6], among which Cu-Au-based systems have aroused high interest for various applications in catalysis (CO 2 and p-nitrophenol reduction, methanol, and CO oxidation [6]), photonics (sensors for the detection of persistent toxic organic pollutants [26]), or biomedical research (photothermal therapy [27]). The alloying of copper with gold is an effective method to reduce the gold costs and to improve the stability of copper, while benefiting from their individual properties: Au is a biocompatible element with high stability, size-tunable surface plasmon resonance, fluorescence, and easy-surface functionalization [28], and copper has unique catalytic and optical properties [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

High-Efficiency Biocidal Solution Based on Radiochemically Synthesized Cu-Au Alloy Nanoparticles

Lungulescu¹,

Setnescu

Patroi³

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

The use of nanotechnologies in the applied biomedical sciences can offer a new way to treat infections and disinfect surfaces, materials, and products contaminated with various types of viruses, bacteria, and fungi. The Cu-Au nanoparticles (NPs) were obtained by an eco-friendly method that allowed the obtaining in a one-step process of size controlled, well dispersed, fully reduced, highly stable NPs at very mild conditions, using high energy ionizing radiations. The gamma irradiation was performed in an aqueous system of Cu2+/Au3+/Sodium Dodecyl Sulfate (SDS)/Ethylene Glycol. After irradiation, the change of color to ruby-red was the first indicator for the formation of NPs. Moreover, the UV-Vis spectra showed a maximum absorption peak between 524 and 540 nm, depending on the copper amount. The Cu-Au NPs presented nearly spherical shapes, sizes between 20 and 90 nm, and a zeta potential of about −44 mV indicating a good electrostatic stability. The biocidal properties performed according to various standards applied in the medical area, in dirty conditions, showed a 5 lg reduction for Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus hirae, a 5 lg reduction for both enveloped and non-enveloped viruses such as Adenovirus type 5, Murine Norovirus, and human Coronavirus 229E, and a 4 lg reduction for Candida albicans, respectively. Thus, the radiochemically synthesized Cu-Au alloy NPs proved to have high biocide efficiency against the tested bacteria, fungi, and viruses (both encapsulated and non-encapsulated). Therefore, these nanoparticle solutions are suitable to be used as disinfectants in the decontamination of hospital surfaces or public areas characterized by high levels of microbiological contamination.

show abstract

Section: Introductionmentioning

confidence: 99%

High-Efficiency Biocidal Solution Based on Radiochemically Synthesized Cu-Au Alloy Nanoparticles

Lungulescu¹,

Setnescu

Patroi³

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Moreover, nanoparticles did not affect the bodyweight of mice. The results of these in vitro and in vivo tests therefore confirmed the safety of gold nanoparticle use at low concentrations [ 45 ].…”

Section: Nanoparticle Toxicitymentioning

confidence: 70%

“…Therefore, they are mainly applied in the biomedical industry due to their unique surface, electronic, and optical properties. They are also used as innovative tools in diagnostic research, e.g., the detection of heart disease or cancer biomarkers, and in drug delivery systems [ 16 , 42 , 43 , 44 , 45 , 46 , 47 ]. Numerous reports have been published regarding the toxicity of gold nanoparticles depending on their size, shape, or structure of the coating and the spectrum of experimentally measured parameters.…”

Section: Nanoparticle Applicationsmentioning

confidence: 99%

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

2021

View full text Add to dashboard Cite

Silver and gold nanoparticles can be found in a range of household products related to almost every area of life, including patches, bandages, paints, sportswear, personal care products, food storage equipment, cosmetics, disinfectants, etc. Their confirmed ability to enter the organism through respiratory and digestive systems, skin, and crossing the blood–brain barrier raises questions of their potential effect on cell function. Therefore, this manuscript aimed to summarize recent reports concerning the influence of variables such as size, shape, concentration, type of coating, or incubation time, on effects of gold and silver nanoparticles on cultured cell lines. Due to the increasingly common use of AgNP and AuNP in multiple branches of the industry, further studies on the effects of nanoparticles on different types of cells and the general natural environment are needed to enable their long-term use. However, some environmentally friendly solutions to chemically synthesized nanoparticles are also investigated, such as plant-based synthesis methods.

show abstract

“…Another highly biocompatible element that belongs to the same family as Ag and Cu is gold (Au) [ 34 ]. Recently, a simulative first principle study reported that alloying Au with Ti, can result in an Ti 3 Au intermetallic structure, possessing extremely high hardness [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Thermal activation of Ti(1-x)Au(x) thin films with enhanced hardness and biocompatibility

Lukose

Anestopoulos

Mantso

et al. 2022

Bioactive Materials

View full text Add to dashboard Cite

Biocompatibility of gold nanoparticles: In-vitro and In-vivo study

Cited by 41 publications

References 21 publications

High-Efficiency Biocidal Solution Based on Radiochemically Synthesized Cu-Au Alloy Nanoparticles

High-Efficiency Biocidal Solution Based on Radiochemically Synthesized Cu-Au Alloy Nanoparticles

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

Thermal activation of Ti(1-x)Au(x) thin films with enhanced hardness and biocompatibility

Contact Info

Product

Resources

About