Biocompatibility of Dental Adhesives

Abstract

The accomplishment of developing a truly adhesive bond between a restorative material and the natural tooth structures is the goal of adhesive dentistry. Dentine adhesive systems come into close contact with dental and oral tissue, especially the pulp and gingival cells. Due to this close and long-term contact, adhesives should exhibit a high degree of biocompatibility. "iocompatibility is one of the most important properties of dental materials, and adhesives are no exception. It has been long demonstrated that diferent components of adhesives can be released. Numerous in vitro investigations have shown that released monomers and other components can cause damage to cultured cells. In addition, many in vivo studies have shown that uncured components which reach the pulpal space cause inlammatory response and tissue disorganization. Only a combination of various in vitro and in vivo tests can provide an overview of the interaction of biomaterials with the host. Therefore, it is necessary on a regular basis to carry out and re-verify the biological compatibility of the increasing number of new dental materials. "dhesives should be biofunctional, protective, and preventive, with health-promoting efects that contribute to a beter prognosis for restorative treatments and its biocompatibility.

Evaluation of biocompatibility of four different one-step self-etching adhesives by animal experimental method

“…18 In the first 24-48 hours following the polymerization of the monomers, the rate of cytotoxicity is at its highest level. 19 This reveals the importance of the remaining dentin thickness Differences Over Time (20). In a study.…”

“…21 Today, many materials are offered for clinical use without concern about their biocompatibility. 20 The effects of dental materials on teeth and surrounding tissues, their safety, and their biocompatibility should be investigated before clinical use. 22,23 In studies, it is mentioned that these components released from adhesive materials into the oral environment cause a number of local and systemic side effects or allergic reactions.…”

Effects of Short-Term Exposure of Chloramine-T Solution on the Characteristics of Light-Cured and Chemical-Cured Adhesives

“…Nonetheless, it is very important to evaluate the clinical performance of dental adhesives in a more clinically relevant environment [64]. Also, considering the direct contact of dental adhesives with both hard and soft dental tissues, the evaluation of biocompatibility, bioactivity, and biodegradability of dental adhesives needs to be addressed critically [65,66]. To the best of our knowledge, no study has been conducted to evaluate the cytotoxic and other biological effects of these two dental adhesives.…”

Synthesis of di- and triacrylamides with tertiary amine cores and their evaluation as monomers in dental adhesive interfaces

“…Dental adhesives intimately interact with vital dentine and, in many cases, are placed in close contact with the pulp chamber, which facilitates the diffusion of leachates and unreacted monomers through the dentinal tubules into the pulp cavity at toxic concentrations [42]. It has been claimed that the release of certain adhesive components can cause genotoxic, allergic, cytotoxic, mutagenic, and estrogenic effects [42]. Despite the extensive use of acrylamides in wastewater treatment, general polymer industry, cosmetics and foods, they are identified as potentially cytotoxic for certain cell lines [43].…”