Biocompatibility of conventional acrylic resin versus modified with titanium dioxide nanoparticles in maxillofacial prosthesis. A parallel randomized control trial

Abstract

Statement of the problem: Biocompatibility of the maxillary obturators, is one of the most important bases for excellent prognosis. The modified acrylic resin with titanium dioxide nanoparticles has been shown to be an efficient form of poly (methyl methacrylate) resin for the fabrication of dentures. Objective:The aim of this study is to evaluate the biocompatibility of the obturator constructed with the modified acrylic resin compared to the conventional one. Materials and Methods:Fourteen patients with acquired maxillary defect were selected to participate in this study, the patients were divided randomly into two groups. Group I patients received obturators constructed from the conventional (poly methyl methacrylate) acrylic resin, Group II patients received obturators constructed from (poly methyl methacrylate) acrylic resin modified by the addition of titanium dioxide nanoparticles. Three swabs were taken from each patient (one from the fitting surface of the obturator facing the defect and the two others were obtained from the nasal and palatal surfaces of the defect) these swabs at 3 months and 6 months after insertion. The results were collected, tabulated and statistically analyzed. Results:As regard the incidence of bacteria harbored in the defect there was an increase in the bacterial count throughout the follow up period in both groups. The increase was statistically significant in group 1 while was non-significant in group 2. Conclusion:The use of modified acrylic resin with titanium dioxide nanoparticles in obturators construction obviously improved its biocompatibility