Biocompatibility of boron nitride nanosheets

Mateti, Srikanth; Wong, Cynthia S.; Liu, Zhen; Yang, Wenrong; Li, Yuncang; Li, Lu Hua; Chen, Ying

doi:10.1007/s12274-017-1635-y

Cited by 120 publications

(90 citation statements)

References 38 publications

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“…Mateti et al 42 reported another interesting observation on the biocompatibility of boron nitride nanosheets. They produced nanoparticles in different dimensions through a process of ball milling in argon, and ammonia for nanosheets in order to allow the exfoliation of sheets.…”

Section: Ivan Mijakovicmentioning

confidence: 98%

Boron nitride nanomaterials: biocompatibility and bio-applications

et al. 2018

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Boron nitride has structural characteristics similar to carbon 2D materials (graphene and its derivatives) and its layered structure has been exploited to form different nanostructures such as nanohorns, nanotubes, nanoparticles and nanosheets. Unlike graphene and other carbon based 2D materials, boron nitride has a higher chemical stability. Owing to these properties, boron nitride has been used in different applications as a filler, lubricant and as a protective coating. Boron nitride has also been applied in the biomedical field to some extent, but far less than other 2D carbon materials. This review explores the potential of boron nitride for biomedical applications where the focus is on boron nitride biocompatibility in vivo and in vitro, its applicability as a coating material/composite and its anti-bacterial properties. Geometry, material processing and the type of biological analysis appear to be relevant parameters in assessing boron nitride bio-compatibility. Engineering of both these variables and the coating would open the door for some applications in the medical field for boron nitride, such as drug delivery, imaging and cell stimulation.

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Section: Ivan Mijakovicmentioning

confidence: 98%

Boron nitride nanomaterials: biocompatibility and bio-applications

et al. 2018

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“…Thanks to these features, graphene has long been studied for applications in the field of biomedical technologies. In the last decades, an increasing interest rose in the scientific community for the development of novel graphene-based scaffolds characterized by biocompatibility [2,3], long-term durability [4], and flexibility [5]. Prototypes under study are wearable devices [6], implantable microelectrodes and microtransistors [7], or in vivo cortical, retinal and peripheral nerve probes [8].…”

Section: Introductionmentioning

confidence: 99%

A hybrid P3HT-Graphene interface for efficient photostimulation of neurons

DiFrancesco

Colombo

Papaleo

et al. 2020

Carbon

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a b s t r a c tGraphene conductive properties have been long exploited in the field of organic photovoltaics and optoelectronics by the scientific community worldwide. We engineered and characterized a hybrid biointerface in which graphene is coupled with photosensitive polymers, and tested its ability to elicit lighttriggered neural activity modulation in primary neurons and blind retina explants. We designed such a graphene-based device by modifying a photoactive P3HT-based retinal interface, previously reported to rescue light sensitivity in blind rodents, with a CVD graphene layer replacing the conductive PEDOT:PSS layer to enhance charge separation. The new graphene-based device was characterized for its electrochemical features and for the ability to photostimulate primary neurons and blind retina explants, while preserving biocompatibility. Light-triggered responses, recorded by patch-clamp in vitro or MEA ex vivo, show a stronger light-transduction efficiency when the neurons are interfaced with the graphene-based device with respect to the PEDOT:PSS-based one. The possibility to ameliorate flexible photo-stimulating devices via the insertion of graphene, paves the way for potential biomedical applications of graphenebased neuronal interfaces in the context of retinal implants.

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“…Pure and Zr-doped BN nanosheets as indicated in Fig. 5(a-d) are produced as a result of chemical exfoliation of bulk BN which exhibit good antimicrobial activity because of their change in size from bulk to nanoscale (Mateti et al 2018). Experimental results indicate that FESEM and HRTEM analysis agree well with each other.…”

Section: Resultsmentioning

confidence: 58%

“…Interaction of BN nanosheets to exhibit biocompatibility has been reported using molecular dynamic simulation. Few experimental investigations have been reported to highlight the biocompatibility of BN nanosheets with kidney such that the BN nanosheets with optimum length of 10 mm, synthesized by chemical vapor deposition process exhibited zero cytotoxicity (Mateti et al 2018). Cytotoxic and cell viability experiments showed direct proportionality between concentration and exposure time of BN nanosheets with regard to its biocompatibilty performance (Horvath et al 2011;Ciofani et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Bactericidal behavior of chemically exfoliated boron nitride nanosheets doped with zirconium

et al. 2020

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In this work, boron nitride nanosheets (BNNS) were produced through chemical exfoliation of bulk boron nitride (BN). Furthermore, hydrothermal technique was used to incorporate various concentrations (2.5, 5, 7.5, and 10 wt%) of zirconium (Zr) as a dopant. The prepared undoped and doped BN samples were evaluated for its antimicrobial activity against E. coli and S. aureus. Structural analysis was undertaken using x-ray diffraction which identified the presence of hexagonal BN. FTIR and Raman spectroscopy were utilized to outline IR fingerprint and electronic properties of the synthesized material. Morphological information was obtained through micrographs extracted using field emission scanning electron spectroscope (FESEM) and high resolution transmission electron microscope (HRTEM), while d-spacing was also calculated through HRTEM analysis. Optical properties and emission spectra were examined by applying UV-vis and photoluminescence spectroscope (PL); whereas, band gap analysis was carried out via Tauc plot. Zr-doped BN nanosheets at increasing concentrations (0.5, 1.0 mg/50 μl) revealed enhanced antibacterial activity against E. coli compared to S. aureus (p < 0.05).

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Biocompatibility of boron nitride nanosheets

Cited by 120 publications

References 38 publications

Boron nitride nanomaterials: biocompatibility and bio-applications

Boron nitride nanomaterials: biocompatibility and bio-applications

A hybrid P3HT-Graphene interface for efficient photostimulation of neurons

Bactericidal behavior of chemically exfoliated boron nitride nanosheets doped with zirconium

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