Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen

He, Yaohua; Tao, Hairong; Zhang, Yan; Jiang, Yao; Zhang, ShaoXiang; Zhao, Changli; Li, JiaNan; Zhang, BeiLei; Song, Yang; Zhang, Xiaonong

doi:10.1007/s11434-009-0080-z

Cited by 62 publications

(31 citation statements)

References 9 publications

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“…The application of alloys and implant materials placed into the extracted sockets immediately after tooth extraction have reported beneficial effects; 6,7 however, such techniques could not demonstrate their capability of maintaining the bony crest in its original shape for long periods of time because of their high corrosion and degradation in vivo. The biological and corrosion properties of Mg alloys have been studied in detail, [8][9][10][11] and their application as orthopedic implants has been widely accepted due to (1) their characteristic biodegradability and biocompatibility in vivo, [8][9][10] and (2) their established role in bone formation, eg, ability to influence mineral metabolism in the bone matrix and promotion of osteoblast specific cell signaling in vivo, without causing inflammatory reactions in the neighboring tissues. 12 In addition, mechanical properties such as elastic modulus and compressive yield strength of many Mg based alloys closely match with that of natural bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary

Sravanthi²,

Li³

et al. 2013

IJN

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Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.

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Section: Introductionmentioning

confidence: 99%

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary

Sravanthi²,

Li³

et al. 2013

IJN

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“…However, the commonly used metallic materials, including titanium alloys, stainless steels and cobalt based alloys will cause some problems such as stress shielding effects which lead to decreased bone strength and delay in bone healing, and release of toxic ions or particles which can result in chronic inflammation and bone dissolution [1][2][3][4]. Moreover, the metallic bone implants are permanent and most of them need to be taken out via a second operation, which not only raises the costs, but also brings unwanted suffering to patients.…”

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confidence: 99%

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

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In this study, in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr (NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial. Its corrosion properties were evaluated by static immersion test, electrochemical corrosion test, scanning electron microscopy (SEM), and energy dispersive spectroscopic (EDS) analysis, and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests. Pure magnesium was used as control. The results of static immersion test and electrochemical corrosion test in simulated body fluid (SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance. The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, which was lower than the safe value of 5%. The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC 3 T 3 -E 1 cell viability. Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro. Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.

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“…Ca-P coatings such as HA, DCPD, -Ca 2 P 2 O 7 and -TCP, are close in composition to natural bone and can accelerate the bone growth [4][5][6]. Therefore, in this study, a Ca-P coating is prepared on a ZK60 magnesium alloy substrate, a material compatible with human tissue [7]. Methods reported to form a Ca-P coating on a magnesium alloys substrate include chemical conversion and electro deposition, but so far, little has been published on fabricating a Ca-P coating on Mg alloy by hydrothermal methods.…”

mentioning

confidence: 99%

Preparing Ca-P coating on biodegradable magnesium alloy by hydrothermal method: In vitro degradation behavior

Wang

Yan

et al. 2012

Chin. Sci. Bull.

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Magnesium alloys are potentially attractive biodegradable materials. However, their rapid corrosion rate limits their biomedical application. To slow down the rate of biodegradation, a protective calcium-phosphate coating was formed on a magnesium alloy substrate by a hydrothermal method. Scanning electron microscope results showed that the coating consisted of two layers with different crystalline characteristics. The loose outer layer showed a prism-like crystal structure, while the compact inner layer is a dense ultra-fine regular di-pyramid-like structure with an average grain dimension of ~200 nm. The compositions of the inner layer and outer layer were calcium-deficient hydroxyapatite (Ca-def HA) and dicalcium phosphate (DCPa), respectively. The coating adhered well to the substrate with a thickness of about 15 m. Immersion in Hank's solution indicated that the coating could significantly improve the degradation properties of magnesium alloy. The pH of the solution containing the coated samples increased much more slowly than the untreated control. After 8 d immersion, the uncoated sample had corroded seriously while the coated sample was much less corroded. The Ca/P atom ratio in both the layers of the coating increased and the coating was still protecting the substrate. The two layers of the coating corroded differently because of differences in solubility. The outer layer was more severely attacked and many holes were formed on the surface, the inner layer suffered less attack. In addition, a growth of precipitate on the inner layer was observed, indicating that surface bioactivity was improved by the coating. Thus, magnesium alloys coated with a Ca-P coating prepared by a hydrothermal method are promising candidate biodegradable biomaterials, and further investigation of in vivo degradation behavior is suggested. biomaterials, magnesium alloys, Ca-P coating, hydrothermal method, degradation, hydroxyapatite Citation:Li K K, Wang B, Yan B, et al. Preparing Ca-P coating on biodegradable magnesium alloy by hydrothermal method: In vitro degradation behavior. Chin

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Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen

Cited by 62 publications

References 9 publications

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Preparing Ca-P coating on biodegradable magnesium alloy by hydrothermal method: In vitro degradation behavior

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