Biocompatibility of a New Polycarbonate Dialysis Membrane

Abstract

The present report summarizes our experience with a new polycarbonate (PC)- based dialysis membrane (Gambro Lundia® PRO-5) compared with a cuprophan (CP)-based membrane (Gambro Lundia® 10-5N).Platelet count decreased during dialysis with CP, but was unchanged with PC membranes. Platelet injury, reflected by decreased platelet aggregation and increase in plasma β-thrombo-globulin, occurred equally with both membranes. Complement activation (C3d and C5a), leukopenia and release of granulocyte-derived elastase was more extensive with CP than with PC membranes. The new membrane represents an improvement of biocompatibility with respect to the complement-leukocyte system, whereas the effect on platelets resembles the injury caused by CP membranes.

Efficacy and Safety of a Polyester Leukocyte Removal Filter for Whole Blood and Red Cell Concentrate Filtration

“…Frequently observed adverse clinical reactions to other models of extracorporeal blood circuits, such äs haemodialysis and cardiopulmonary bypass, have been ascribed to granulocyte activation with the concomitant generation of large amounts of toxic oxygen species (e. g. Superoxide anion, hydrogen peroxide), discharge of primary and secondary granule contents (e. g. elastase, cathepsin) and complement activation (7)(8)(9)(10)(11)(12).…”

Η Λειτουργία Των Αιμοπεταλίων Στη Χρόνια Νεφρική Ανεπάρκεια Και Στη Συνεχή Φορητή Περιτοναϊκή Κάθαρση

“…Ετσι, οι Remmuzi και συν. 89 παρατήρησαν ότι τα αιμο πετάλια ουραιμικών αρρώστων, λίγο πριν από την προγραμματισμένη συνεδρία αιμοκάθαρσης, ήταν πιο ευαίσθητα απ' ότι των υγιών στη διέγερση με χαμηλές συγκεντρώσεις αραχιδονικού οξέος (ΑΑ), όπως φάνηκε από τη μεγαλύτερη παραγωγή MDA και ΤΧΒ2 αλλά και τη μεγαλύτερη ικανότητα συσσώρευσης. Στις μεγαλύτερες συγκεντρώσεις ΑΑ παρατηρήθηκε το αντίθετο.…”