Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3

Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment

“…18,19 Solubilizing agents, such as cyclodextrin, polyvinylpyrrolidone, calixarene, and liposome, were used to wrap fullerenes and make them soluble in water. [20][21][22][23][24][25] A variety of hydrophilic and biomolecular units, such as hydroxyl, [26][27][28] carboxyl, [29][30][31] amino acid, [32][33][34] peptide, 19,35,36 and sugar, 2,37,38 were conjugated to the surface of fullerene, resulting in many kinds of water-soluble fullerene derivatives. Besides these, water-soluble polymers conjugated to the fullerene surface, [39][40][41] fullerene as the end cap of water-soluble polymers, 42,43 fullerene connected to the side chain of water-soluble polymers, 44,45 main chain water-soluble fullerene-polymers, 46 copolymerization of fullerene functionalized monomer with N-vinylpyrrolidone 47 are also useful methods to achieve water-soluble targets.…”