Biocompatibility of a Glucose-Polymer-Containing Peritoneal Dialysis Fluid

Fijter, C. W. H. De; Verbrugh, Henri A.; Oe, Liem P.; Heezius, Erik; Donker, A. J. M.; Verhoef, J.; Gokal, Ram

doi:10.1016/s0272-6386(12)80270-8

Cited by 80 publications

(38 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over the past few decades, a glucose polymer with an average molecular weight of 12,000–20,000 daltons has increasingly been used as an alternative osmotic agent to glucose [4, 5]. It has been shown that a 7.5% glucose polymer-based peritoneal dialysis (PD) solution can provide sustained positive ultrafiltration that is equivalent to the effect of a 3.86% glucose solution.…”

Section: Introductionmentioning

confidence: 99%

Effect of Glucose Polymer on the Intercellular Junctions of Cultured Human Peritoneal Mesothelial Cells

Ito

Yorioka²,

Kyuden³

et al. 2004

Nephron Clin Pract

View full text Add to dashboard Cite

Background: Glucose polymer is an active osmotic agent that is increasingly used as an alternative to glucose in peritoneal dialysis fluids. It was recently reported that the duration of peritoneal dialysis can be extended by using glucose polymer in patients with poor ultrafiltration. We previously demonstrated that high glucose levels damage the intercellular junctions of cultured human peritoneal mesothelial cells (HPMC), but little is known about the influence of glucose polymer. Therefore, we investigated the effects of glucose polymer on the intercellular junctions of HPMC. Methods: HPMC were isolated, cultured, and identified according to the modified method of Stylianou. M199 medium was supplemented with peritoneal dialysis solutions containing 7.5% glucose polymer or 1.5, 2.5, and 4.25% glucose. After 6 h, cell viability was assessed, intercellular junction proteins were examined by immunofluorescence techniques, and the concentration of transforming growth factor-β1 in the culture supernatant was determined. Results: Glucose significantly suppressed cell viability and significantly increased transforming growth factor-β1 production when compared with control or glucose polymer cultures. Peritoneal dialysis solutions containing 4.25% glucose caused the detachment of HPMC. Immunofluorescence of intercellular junction proteins (tight junctions: ZO-1, occludin, and claudin-1; adherens junctions: β-catenin) became weak and uneven after culture with glucose. On the other hand, glucose polymer caused little change in the immunofluorescence of these proteins when compared with control cultures. Conclusions: Glucose polymer seems to be less toxic to HPMC than glucose itself, suggesting that the glucose polymer may be better for peritoneal dialysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Glucose Polymer on the Intercellular Junctions of Cultured Human Peritoneal Mesothelial Cells

Ito

Yorioka²,

Kyuden³

et al. 2004

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…Icodextrin is a glucose polymer that has increasingly been used as an alternative osmotic agent to glucose [50,51]. It has been shown that a 7.5% icodextrin-based PD solution can provide sustained positive ultrafiltration equivalent to that achieved with a 3.86% glucose-based PD solution [52].…”

Section: Icodextrinmentioning

confidence: 99%

Peritoneal damage by peritoneal dialysis solutions

Ito

Yorioka

2008

Clin Exp Nephrol

View full text Add to dashboard Cite

Continuous ambulatory peritoneal dialysis is a well-accepted treatment for end-stage renal disease, but its long-term success is limited. Peritoneal sclerosis is still one of the most important complications of long-term peritoneal dialysis and the low biocompatibility of peritoneal dialysis solutions plays a major role in the development of such sclerosis. In this review, we summarize recent experimental data about the biocompatibility of peritoneal dialysis solutions.

show abstract

“…de Fijter et al have shown that granulocytes and monocytes have better phagocytic function in icodextrin than glucose-based PDF. They have also shown that this advantage is lost when osmolality of icodextrin fluid is increased [72]. A 7.5% icodextrin results in less in vitro AGE formation [73], and less fibroblast proliferation [74].…”

Section: Icodextrin-based Pdfsmentioning

confidence: 99%

Prevention of membrane damage in patient on peritoneal dialysis with new peritoneal dialysis solutions

et al. 2006

View full text Add to dashboard Cite

Peritoneal dialysis (PD) is now an established and successful alternative to hemodialysis. Multiple studies have confirmed its equivalent dialysis adequacy, mortality and fluid balance status, at least for the first 4-5 years. Peritoneal membrane failure is now one of the leading cause of technique failure. This review describes the role of glucose, glucose degradation product, pH, lactate, advanced glycosylation end product (AGE) in causing this membrane damage, and gives insight how the use of newer peritoneal dialysis fluids (PDFs) containing icodextrin, amino acids and bicarbonate buffer can prevent peritoneal membrane damage.

show abstract

Biocompatibility of a Glucose-Polymer-Containing Peritoneal Dialysis Fluid

Cited by 80 publications

References 25 publications

Effect of Glucose Polymer on the Intercellular Junctions of Cultured Human Peritoneal Mesothelial Cells

Effect of Glucose Polymer on the Intercellular Junctions of Cultured Human Peritoneal Mesothelial Cells

Peritoneal damage by peritoneal dialysis solutions

Prevention of membrane damage in patient on peritoneal dialysis with new peritoneal dialysis solutions

Contact Info

Product

Resources

About