Biocompatibility evaluation of aniline oligomers with different end-functional groups

Qi, Hongxu; Liu, Meiying; Xu, Li Chong; Feng, Lin; Tao, Lei; Ji, Yan; Zhang, Xiaoyong; Wei, Yen

doi:10.1039/c3tx50060h

Cited by 53 publications

(41 citation statements)

References 69 publications

(77 reference statements)

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“…3A-C). [41][42][43] The decrease of the cell viability wasn't obvious when the cell was incubated with the various concentration of Flu-Ply FONs, and the cell viability was still more than 90% even when cells were incubated with as high as 120 mg mL À1 of Flu-Ply FONs. 3D.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

et al. 2015

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Due to the good biocompatibility, 3-polylysine (Ply) has been extensively investigated for various biomedical applications. In this study, a fluorescent monomer (named Flu-MA) was firstly synthesized through acylation reaction of fluorescein by methacryloyl chloride, and the initiator of 3-polylysine bromide (named Ply-Br) was prepared by the introduction of a bromine atom into Ply by the acylation reaction of Ply with abromoisobutyryl bromide. Subsequently, a novel amphiphilic fluorescent polymer (Flu-Ply) was successfully fabricated by ATRP via incorporation of Flu-MA monomer into Ply chains for the first time.The structure and properties of the obtained Flu-Ply fluorescent polymer were investigated in detail by 1 H NMR, TEM, UV-vis, FL and FTIR, and the results confirmed the successful incorporation of Flu-MA into Ply by ATRP. As a result of Flu-MA and Ply respectively endowing the as-prepared Flu-Ply polymer with fluorescence and water dispersibility, it tended to self-assemble into fluorescent organic nanoparticles (FONs) with excellent biocompatibility. More importantly, the good fluorescence, uniform spherical morphology, excellent biocompatibility and water dispersibility of Flu-Ply FONs exhibited an attractive prospect for bioimaging applications.

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Section: Resultsmentioning

confidence: 99%

Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

et al. 2015

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“…The cell viability was further used to quantitatively evaluate the biocompatibility of CNT-PDA-PEGMA using the WST assay as described in our previous reports [51][52][53]. Briefly, cells were seeded in 96-well microplates at a density of 5 × 10 4 cells per mL in 160 L Then the cells were washed with PBS for three times to remove the uninternalized nanoparticles.…”

Section: Biocompatibility Evaluation Of Cnt-pda-pegmamentioning

confidence: 99%

PEGylation of carbon nanotubes via mussel inspired chemistry: Preparation, characterization and biocompatibility evaluation

Zhang

Zeng

Tian

et al. 2015

Applied Surface Science

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a b s t r a c tA novel strategy for surface modification of multi-walled carbon nanotubes (MWCNT) was developed via combination of mussel inspired chemistry and Michael addition reaction. In this procedure, pristine MWCNT were first coated with polydopamine (PDA) through self polymerization of dopamine. The PDA functionalized CNT (CNT-PDA) were further functionalized with amino-terminated polymers (polyPEGMA), which were synthesized via free radical polymerization using cysteamine hydrochloride as the chain transfer agent and poly(ethylene glycol) monomethyl ether methacylate as the monomer. The successful modification of CNT was ascertained by a series of characterization techniques including transmission electron microscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis and X-ray photoelectron spectrometry. The polymer modified CNT showed enhanced dispersibility in aqueous and organic solution. Cytotoxicity evaluation of polymers modified CNT showed that these modified CNT are biocompatible with cells. Finally, due to the universal adhesive of PDA and chain transfer free radical polymerization, this strategy developed in this work can also be extended for surface modification of many other nanomaterials with different functional polymers.

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“…[57] Three erythrocyte suspensions (10% hematocrit per sample) were incubated with 200 µg mL −1 suspensions of GO/AgNPs, respectively. One mixed sample as model group was incubated at 37 °C, the other two mixed samples are added into 100 µL of simvastatin for incubating at 37 °C.…”

Section: Effect Of Simvastatin On Hematology Markers and Pathologicalmentioning

confidence: 99%

Graphene Oxide/Ag Nanoparticles Cooperated with Simvastatin as a High Sensitive X‐Ray Computed Tomography Imaging Agent for Diagnosis of Renal Dysfunctions

Zhan

Tian

Liu

et al. 2017

Adv Healthcare Materials

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Graphene oxides (GO) are attracting much attention in the diagnosis and therapy of the subcutaneous tumor as a novel biomaterial, but its diagnosis to tissue dysfunction is yet to be found. Here, a novel application of GO for diagnosis of renal dysfunction via contrast‐enhanced computed tomography (CT) is proposed. In order to serve as contrast‐enhanced agent, Ag nanoparticles (AgNPs) are composited on the surface of GO to promote its X‐ray absorption, and then simvastatin is coinjected for eliminating in vivo toxicity induced by AgNPs. It is found that GO/AgNPs can enhance the imaging of CT into the lung, liver, and kidney of mice for a long circulation time (≈24 h) and a safety profile in vivo in the presence of simvastatin. Interestingly, the lower dose of GO/AgNPs (≈0.5 mg per kg bw) shows an excellent performance for CT imaging of renal perfusion, and visually exhibits the right renal dysfunction in model mice. Hence, this work suggests that graphene nanoparticles will play a vital role for the future medical translational development including drug carrier, biosensing, and disease therapy.

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Biocompatibility evaluation of aniline oligomers with different end-functional groups

Cited by 53 publications

References 69 publications

Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

PEGylation of carbon nanotubes via mussel inspired chemistry: Preparation, characterization and biocompatibility evaluation

Graphene Oxide/Ag Nanoparticles Cooperated with Simvastatin as a High Sensitive X‐Ray Computed Tomography Imaging Agent for Diagnosis of Renal Dysfunctions

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