Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix

Abstract

This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and thermal steadiness as well as biocompatibility of resultant composites. Electrospun, well-aligned, POSS-grafted PU nanofibers were prepared. Physicochemical investigation was conducted using several experimental techniques, including scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, Fourier transform infrared spectroscopy, and X-ray diffraction pattern. Adding POSS molecules to PU did not influence the processability and morphology of the nanocomposite; however, we observed an obvious mean reduction in fiber diameter, which amplified specific areas of the POSS-grafted PU. Prospective biomedical uses of nanocomposite were also appraised for myoblast cell differentiation in vitro. Little is known about C2C12 cellular responses to PU, and there is no information regarding their interaction with POSS-grafted PU. The antimicrobial potential, anchorage, proliferation, communication, and differentiation of C2C12 on PU and POSS-grafted PU were investigated in this study. In conclusion, preliminary nanocomposites depicted superior cell adhesion due to the elevated free energy of POSS molecules and anti-inflammatory potential. These nanofibers were non-hazardous, and, as such, biomimetic scaffolds show high potential for cellular studies and muscle regeneration.

Chitosan-Functionalized Hydroxyapatite-Cerium Oxide Heterostructure: An Efficient Adsorbent for Dyes Removal and Antimicrobial Agent

“…The virgin HAP and CS-HAP-CeO 2 heterostructure were also evaluated using varying amounts against E. coli [ 66 , 67 ]. The produced heterostructure proved reputable antimicrobial activity against E. coli (MIC-50 μg/mL).…”

Manganese Ferrite–Hydroxyapatite Nanocomposite Synthesis: Biogenic Waste Remodeling for Water Decontamination

“…The virgin HAP and HAP-MnFe 2 O 4 nanocomposites were also evaluated for their consumption of varying amounts of S. aureus and E. coli , applying our earlier established assay [ 33 , 34 ]. The synthesized nanocomposites demonstrated estimable antimicrobial activity against both Gram-negative E. coli and Gram-positive S. aureus , with MICs of 50 μg/mL.…”

NHC‐Rhodium‐Catalyzed Synthesis of Novel Silsesquioxanes Containing S‐Si and S‐Ge Bonds and Their Application in Hydrosilylation Process

“…[1][2][3][4][5] Recently, much attention has been paid to their use biomedical fields, [6][7][8][9][10] mainly due to their biocompatibility, non-toxicity, thermal and chemical stability, the ability to self-assembly and to form porous structures. [11,12] On top of that, they have been shown to facilitate cell proliferation and create superhydrophobic surfaces. Additionally, SQs can be easily modified by the introduction of different organic functional groups to the silica-like core, [13] which allows obtaining new materials showing desired properties.…”