Biocompatibility, cell growth and clinical relevance of synthetic meshes and biological matrixes for internal support in implant-based breast reconstruction

Dieterich, M.; Stubert, Johannes; Gerber, Bernd; Reimer, Toralf; Richter, Dagmar

doi:10.1007/s00404-014-3578-9

Cited by 25 publications

(19 citation statements)

References 25 publications

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“…[31] Furthermore, PP biomaterials may increase oxidative stress in cultured cells, which is in relation with inflammatory potential. [31] However, the use of novel SCTLAS was able to reduce this inflammatory reaction in host tissues 14 days after grafting and at day 28 with PP/PG-SCTLAS. This could be explained by the presence of SC in the SCTLAS.…”

Section: Discussionmentioning

confidence: 99%

Generation and Evaluation of Novel Stromal Cell‐Containing Tissue Engineered Artificial Stromas for the Surgical Repair of Abdominal Defects

Martín-Piedra

Garzón

Gómez-Sotelo

et al. 2017

Biotechnology Journal

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Repair of abdominal wall defects is one of the major clinical challenges in abdominal surgery. Most biomaterials are associated to infection and severe complications, making necessary safer and more biocompatible approaches. In the present work, the adequate mechanical properties of synthetic polymer meshes with tissue-engineered matrices containing stromal mesenchymal cells is combined to generate a novel cell-containing tissue-like artificial stroma (SCTLAS) for use in abdominal wall repair. SCTLAS consisting on fibrin-agarose hydrogels seeded with stromal cells and reinforced with commercial surgical meshes (SM) are evaluated in vitro and in vivo in animal models of abdominal wall defect. Inflammatory cells, collagen, and extracellular matrix (ECM) components are analyzed and compared with grafted SM. Use of SCTLAS results in less inflammation and less fibrosis than SM, with most ECM components being very similar to control abdominal wall tissues. Cell migration and ECM remodeling within SCTLAS is comparable to control tissues. The use of SCTLAS could contribute to reduce the side-effects associated to currently available SM and regenerated tissues are more similar to control abdominal wall tissues. Bioengineered SCTLAS could contribute to a safer treatment of abdominal wall defects with higher biocompatibility than currently available SM.

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Section: Discussionmentioning

confidence: 99%

Generation and Evaluation of Novel Stromal Cell‐Containing Tissue Engineered Artificial Stromas for the Surgical Repair of Abdominal Defects

Martín-Piedra

Garzón

Gómez-Sotelo

et al. 2017

Biotechnology Journal

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“…Where a mesh was used, it was TiLOOP Bra (pfm medical, Cologne, Germany), which is made of nonresorbable, titanized, lightweight polypropylene with a monofilament structure …”

Section: Methodsmentioning

confidence: 99%

Direct-to-implant breast reconstruction: Higher complication rate vs cosmetic benefits

et al. 2018

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“…In comparison to other MS, the TiLOOP ® sling is coated with titanium. The titanium-coated mesh has proven advantages with marginal shrinking characteristics, less inflammatory reactions than conventional mesh [6], and good biocompatibility [7]. So far, there has been only one abstract with preliminary results of the TiLOOP ® male sling in a prospective study with 25 patients published [14].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to other MS, the TiLOOP ® mesh is titanium coated. This is characterised by favourable bioinert qualities [6] and the advantage of minimal shrinking [7]. This is the first study to investigate the efficacy and complication rates of the TiLOOP ® sling.…”

Section: Introductionmentioning

confidence: 99%

The TiLOOP® Male Sling: Did We Forejudge

Hüsch

Kretschmer²,

Thomsen³

et al. 2017

Urol Int

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Introduction: To evaluate the safety and efficacy of the TiLOOP® male sling (pfm medical, Cologne, Germany) used in the treatment for male stress urinary incontinence (SUI). Material and Methods: We retrospectively evaluated a total of 34 patients with a TiLOOP® male sling. Perioperative complication rates were assessed and validated questionnaires were prospectively evaluated to assess quality of life and satisfaction rate. Outcome and complication rates were analysed by using descriptive statistics. Correlation of continence outcome and risk factors was performed with the chi-square test. A p value below 0.05 was considered statistically significant. Results: The majority of patients (70.6%) were diagnosed with mild or moderate male SUI. During surgery, one instance (2.9%) of intraoperative urethral injury was observed. There were no immediate postoperative complications. The mean follow-up time was 44.6 months. An improvement of male SUI was reported by 61.9% of the patients and 38.1% reported no change according the Patient Global Impression of Improvement. The mean perineal pain score was 0.5 according to the international index of pain. Conclusions: The TiLOOP® is a safe treatment option for male SUI in our cohort with a low complication rate. However, the functional outcome of the TiLOOP® was inferior when compared to the outcome of the AdVance® male sling.

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Biocompatibility, cell growth and clinical relevance of synthetic meshes and biological matrixes for internal support in implant-based breast reconstruction

Abstract: Biochemical examination showed good biocompatibility for the investigated meshes and matrix. All products seem to have their value in IBBR and can be recommended for IBBR.

Cited by 25 publications

References 25 publications

Generation and Evaluation of Novel Stromal Cell‐Containing Tissue Engineered Artificial Stromas for the Surgical Repair of Abdominal Defects

Generation and Evaluation of Novel Stromal Cell‐Containing Tissue Engineered Artificial Stromas for the Surgical Repair of Abdominal Defects

Direct-to-implant breast reconstruction: Higher complication rate vs cosmetic benefits

The TiLOOP® Male Sling: Did We Forejudge

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