Biocompatibility and small protein permeability of hydrophilic-coated membrane dialyzer (NV) in hemodialysis patients: a pilot study

Kodama, Hirotoshi; Tsuji, Akira; Fujinoki, Akihiro; Ooshima, Koujirou; Ishizeki, Kaori; Inoue, Tatsuo

doi:10.1186/s41100-017-0121-z

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“…A lot of risk factors for mortality have been proposed in hemodialysis patients [6]. Biocompatibility of hemodialysis membranes affects the survival, morbidity, and quality of life of uremic patients undergoing maintenance HD therapy [7]. It is well-known that interactions between blood and the hemodialysis membrane include complement activation, direct activation of cellular components, and initiation of the coagulation cascade [8].…”

Section: Discussionmentioning

confidence: 99%

Comparison of biocompatibility in cellulose triacetate dialysis membranes with homogeneous and asymmetric structures

et al. 2018

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Background: Historically, cellulose-based materials have been used for manufacturing hemodialysis membranes and remain to date as the commonly used materials. Though cellulose triacetate (CTA) membrane originally has a homogeneous structure, recently, CTA membrane with asymmetric structure (ATA®) was developed. By a new spinning technology, irregularities or roughness in the inner surface of ATA have become less than those of the conventional CTA membrane. In this study, a comparison was made between CTA and ATA® membranes in order to evaluate the effect of physical structure of the membrane on the biocompatibility. Methods: We compared the biocompatibility of the following two dialyzers with different triacetate membrane: FB-190UHβ with CTA, and FA-190F with ATA® (both from Nipro, Osaka, Japan). Heparin of 40 units/mL was put in a syringe, and test blood was collected from healthy volunteers. Then, the dialyzer and blood circuit were filled with the test blood. Subsequently, the blood was circulated by a roller pump at the rate of 200 mL/min. We measured the platelet counts, platelet factor 4 (PF4), β-thromboglobulin (β-TG), and CD41 and CD42b platelet surface markers at 30, 120, and 240 min. Results: The average platelet counts at 30, 120, 240 min in CTA and ATA® were similar. The average β-TG and PF4 increased from 87.0 ± 49.0 ng/mL and 30.7 ± 17.3 ng/mL to 1198.5 ± 1017.2 ng/mL and 698.2 ± 574.6 ng/mL with CTA and to 774.3 ± 811.6 ng/mL and 509.0 ± 417.3 ng/mL with ATA®, respectively. The average expression of CD41 and CD42b decreased to 82.8 ± 9.7% and 80.1 ± 11.6% with CTA and 81.9 ± 14.3% and 80.2 ± 13.6% with ATA®, respectively. Conclusions: Observed dialyzers showed less platelet activation as commercial products, and differences between CTA and ATA® were not significant in terms of PF4, β-TG, CD41, and CD42b.

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Section: Discussionmentioning

confidence: 99%

Comparison of biocompatibility in cellulose triacetate dialysis membranes with homogeneous and asymmetric structures

et al. 2018

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Biocompatibility and small protein permeability of hydrophilic-coated membrane dialyzer (NV) in hemodialysis patients: a pilot study

Abstract: Background: We evaluated the biocompatibility and small protein permeability of a newly developed hydrophilic-coated membrane dialyzer (NV) compared with conventional polysulfone dialyzer (APS) for hemodialysis (HD) therapy.

Cited by 1 publication

References 20 publications

Comparison of biocompatibility in cellulose triacetate dialysis membranes with homogeneous and asymmetric structures

Comparison of biocompatibility in cellulose triacetate dialysis membranes with homogeneous and asymmetric structures

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