Biocompatibility and functionalization of diamond for neural applications

Yang, Kai‐Hung; Narayan, Roger J.

doi:10.1016/j.cobme.2019.03.002

Cited by 29 publications

(18 citation statements)

References 70 publications

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“…In recent years, diamond has emerged as a promising electrode material for neurophysiological recording and neurotransmitter sensing. Boron-doped polycrystalline diamond (BDD) offers unique properties, including wide aqueous potential window, chemical inertness, capability for surface modification, tunable electrical conductivity, and biocompatibility (Alcaide et al, 2016 ; Hébert et al, 2016 ; McDonald et al, 2017 ; Yang and Narayan, 2019 ). Despite the many benefits of this material, the mechanical property mismatch between BDD (Young's module of ~10 3 GPa) (Wild and Wörner, 2004 ) and soft tissues is a major obstacle that impedes the development of BDD into fully implantable electrochemical devices.…”

Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…Regardless of electrode type, work has identified factors to improve biocompatibility and reduce corrosion and therefore collect more consistent data. Boron-doped diamond electrodes have been developed to improve electrochemical properties and improve corrosion resistance over several months [79,[88][89][90][91]. Platinum electrodes are recommended over stainless steel electrodes to maintain biocompatibility and minimize risk of signal drift [87].…”

Section: Electrode Design and Performancementioning

confidence: 99%

Microdialysis and microperfusion electrodes in neurologic disease monitoring

Stangler

Kouzani

Bennet

et al. 2021

Fluids Barriers CNS

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Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in these patients, enabling individualized insights for therapy and revealing fundamental principles of human neurophysiology. Increasing interest exists in simultaneously measuring neurochemical biomarkers and electrophysiological data to enhance our understanding of human disease mechanisms. This review compares microdialysis, microperfusion, and implanted EEG probe architectures and performance parameters. Invasive consequences of probe implantation are also investigated along with the functional impact of biofouling. Finally, previously developed microdialysis electrodes and microperfusion electrodes are reviewed in preclinical and clinical settings. Critically, current and precedent microdialysis and microperfusion probes lack the ability to collect neurochemical data that is spatially and temporally coincident with EEG data derived from depth electrodes. This ultimately limits diagnostic and therapeutic progress in epilepsy and glioma research. However, this gap also provides a unique opportunity to create a dual-sensing technology that will provide unprecedented insights into the pathogenic mechanisms of human neurologic disease.

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“…Although glassy carbon and diamond are not toxic, carbon nanoparticles cannot be assumed also non-toxic. Because of a variety of processes for purification and different options for surface modification used by various manufacturers, the toxicity caused by NDs is a concern [120][121][122]. In vitro and in vivo properties such as gene program activity, cell viability, and in vivo physiological and mechanistic behavior in the presence of NDs have been investigated [66,120,[123][124][125][126][127].…”

Section: Biocompatibilitymentioning

confidence: 99%