Biocompatibility and electrochemical evaluation of ZrO2 thin films deposited by reactive magnetron sputtering on MgZnCa alloy

Millán-Ramos, Benjamín; Morquecho-Marín, Daniela; Silva-Bermúdez, Phaedra; Ramírez-Ortega, David; Depablos-Rivera, Osmary; García-López, Julieta; Fernández-Lizárraga, Mariana; Victoria-Hernández, José; Letzig, Dietmar; Almaguer‐Flores, Argelia; Rodil, Sandra E.

doi:10.1016/j.jma.2021.07.010

Cited by 14 publications

(4 citation statements)

References 61 publications

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“…Although both in vitro and in vivo studies emphasized that ZrO 2 -NP have high biocompatibility (Millán-Ramos et al, 2021), the ability of nanoparticles to pass through cell barriers and interfere with intracellular processes may cause serious problems (Asadpour et al, 2016). Administration of ZrO 2 -NP 1 into alveolar macrophages NR8383 cells and isolated mouse lung cells showed high potential for lung toxicity via lactate dehydrogenase and glucuronidase activation, and overproduction of inflammatory mediators (Vennemann et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Alavi,

Asadpour,

Boroushaki

et al. 2024

Toxicol Ind Health

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During recent decades, the application of zirconium dioxide nanoparticles (ZrO2-NP) has been expanded in various fields ranging from medicine to industry. It has been shown that ZrO2-NP has the potential to cross the blood–brain barrier (BBB) and induce neurotoxicity. In the current study, we investigated the in vivo neurotoxicity, as well as, the cellular mechanism of ZrO2-NP toxicity on two neuronal-like cell lines, PC12 and N2a. PC12 and N2a cells were exposed to increasing concentrations of ZrO2-NP (0-2000 µg/ml) for 48 h. The apoptotic effect of ZrO2-NP was determined using annexin V/propidium iodide double staining (by flow cytometry), and western blot analysis of relative apoptotic proteins, including caspase-3, caspase-9, bax, and bcl2. Based on our results, ZrO2-NP at concentrations of 250-2000 μg/mL increased both early and late-stage apoptosis in a concentration-dependent manner. Moreover, the expressions of cleaved-caspase-3 and -9 proteins and the bax/bcl2 ratio were significantly increased. In addition, oral administration of ZrO2-NP (50 mg/kg) to male Wistar rats for 28 days led to the loss of neuronal cells in the cerebral cortex. Taken together, our findings highlighted the role of apoptosis on cytotoxicity induced by ZrO2-NP.

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Section: Introductionmentioning

confidence: 99%

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Alavi,

Asadpour,

Boroushaki

et al. 2024

Toxicol Ind Health

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“…Based on the encouraging results obtained for ceria, we have chosen to use another ceramic material, zirconia, widely used also in dentistry surgery for its mechanical and biocompatibility properties. 25,26 Moreover, ZrO 2 has also been widely used for a huge amount of hydrogenation reactions due to its hydrogen spillover effect.…”

Section: Introductionmentioning

confidence: 99%

Highly active Pd–ZrO₂ electrodes for hydrogen evolution reaction

Minelli

Rondinini

et al. 2023

Sustainable Energy Fuels

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“…Zirconium oxide (ZrO2) is a widely studied and utilized material due to its various exceptional properties, such as biocompatibility 1 , good chemical resistance 2,3 , high transparency in the visible and near-infrared range 4 , high refractive index (2.1 at 633 nm) 5 , wide band gap 6 , high hardness (11)(12)(13)(14)(15)(16)(17)(18), and high melting point (2700 °C) 2,7 as well as photoluminescence properties 8,9 . These properties make ZrO2 useful in various applications such as in the dental field 10,11 , anti-counterfeiting solutions 9 , optical applications [12][13][14][15] , and protective coatings 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Micro-nanostructuring of ZrO2 sol-gel by optical and nanoimprint lithography on various substrate for optical applications

Otero

Crespo‐Monteiro

Gamet

et al. 2023

Novel Patterning Technologies 2023

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Zirconium oxide (ZrO2) is an intensively studied and used material due to its many remarkable physical and chemical properties. The high performances of ZrO2 allows its use in many applications such as coatings against corrosion, wear and oxidation, optical applications, anti-counterfeiting, or in medical applications such as dental or prosthesis. There are many methods to synthesize ZrO2 among which we can mention reactive sputtering, chemical vapor deposition, atomic layer deposition. These techniques are well known in thin film deposition processes. However, they do not allow to easily structure the coatings to produce complex patterns (shapes, micro-nanostructures) on variable substrates in shape and size. Another process of elaboration of ZrO2 thin films is the sol-gel method. This technique makes possible the micro-nanostructuring of the films by optical and nanoimprint-based lithography. In this paper, the authors will describe how the ZrO2 sol-gel can be used to obtain both complex patterns (shapes, micro-nanostructures) by optical lithography (mask lithography, colloidal lithography) and by nanoimprint lithography. The authors will also show the possibility to use this versatile sol-gel and the associated structuring methods to structure complex patterns on variable substrates in their nature and geometry, as well as the possibility of using this process in optical applications. Preliminary results will be presented through several microstructured ZrO2 demonstrators obtained from the microstructuring process on sol-gel layers. The produced layers have been characterized by Raman spectroscopy, scanning electron microscopy, atomic force microscopy. The optical properties (transmittance, reflectance) have also been investigated and a study of the influence of a thermal treatment on the refractive index and thickness of the layer has been carried out.

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Biocompatibility and electrochemical evaluation of ZrO2 thin films deposited by reactive magnetron sputtering on MgZnCa alloy

Cited by 14 publications

References 61 publications

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Highly active Pd–ZrO₂ electrodes for hydrogen evolution reaction

Micro-nanostructuring of ZrO2 sol-gel by optical and nanoimprint lithography on various substrate for optical applications

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Biocompatibility and electrochemical evaluation of ZrO2 thin films deposited by reactive magnetron sputtering on MgZnCa alloy

Cited by 14 publications

References 61 publications

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Zirconium dioxide nanoparticles induced cytotoxicity in rat cerebral cortical neurons and apoptosis in neuron-like N2a and PC12 cell lines

Highly active Pd–ZrO2 electrodes for hydrogen evolution reaction

Micro-nanostructuring of ZrO2 sol-gel by optical and nanoimprint lithography on various substrate for optical applications

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Highly active Pd–ZrO₂ electrodes for hydrogen evolution reaction