Biocompatibility and Electrical Stimulation of Skeletal and Smooth Muscle Cells Cultured on Piezoelectric Nanogenerators

Blanquer, Andreu; Careta, Oriol; Anido-Varela, Laura; Aranda, Aida; Ibáñez, Elena; Estéve, J.; Nogués, Carme; Murillo, Gonzalo

doi:10.3390/ijms23010432

Cited by 7 publications

(5 citation statements)

References 36 publications

(41 reference statements)

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“…Most inorganic piezoelectric materials usually exhibit high piezoelectric properties, such as BaTiO 3 , [64,125] ZnO, [66,[126][127][128] and KNN. [129] However, they often face challenges in practical applications due to issues such as low toughness and poor deformation resistance.…”

Section: Inorganic Piezoelectric Materialsmentioning

confidence: 99%

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Li,

Pan,

Wang

et al. 2024

Small Science

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Tissue damage often causes considerable suffering to patients due to slow recovery and poor prognosis. The use of electroactive materials to deliver biophysical signals plays a key role in regulating tissue regeneration processes. Among these materials, piezoelectric materials have unique electromechanical conversion capabilities, making them suitable for use as cell scaffolds. They can deform and emit electrical signals in response to external stimuli, thereby regulating cell proliferation and differentiation. In this review, recent advances are presented in piezoelectric materials as physical signaling mediators that regulate cell differentiation. The basic mechanisms, classification of these materials, and their different applications in tissue regeneration are described. Finally, a comprehensive discussion of current challenges and prospects in the field is provided. Together, existing experimental results basically show that piezoelectric materials can improve the process and effect of tissue repair, providing new technical options for the development of tissue engineering in the future.

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Section: Inorganic Piezoelectric Materialsmentioning

confidence: 99%

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Li,

Pan,

Wang

et al. 2024

Small Science

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“…In recent years, due to its excellent piezoelectric properties, stable chemical properties, abundant yield in Nature and other advantages, researchers from various backgrounds have taken an interest in researching ZnO, which has become a popular material for biomedical sensors and piezoelectric nanogenerators [ 78 ]. The amount of Zn ions released by the nanogenerator does not interfere with cellular activity or trigger an associated inflammatory response, and the nanogenerator itself is biocompatible and does not elicit an inflammatory response [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

“…Blanquer et al . demonstrated that both smooth muscle cells and skeletal muscle cells can adhere, proliferate and migrate on ZnO nanogenerators [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Wu,

Zou,

Tang

et al. 2024

Burns &Amp; Trauma

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The unique ability of piezoelectric materials to generate electricity spontaneously has attracted widespread interest in the medical field. In addition to the ability to convert mechanical stress into electrical energy, piezoelectric materials offer the advantages of high sensitivity, stability, accuracy and low power consumption. Because of these characteristics, they are widely applied in devices such as sensors, controllers and actuators. However, piezoelectric materials also show great potential for the medical manufacturing of artificial organs and for tissue regeneration and repair applications. For example, the use of piezoelectric materials in cochlear implants, cardiac pacemakers and other equipment may help to restore body function. Moreover, recent studies have shown that electrical signals play key roles in promoting tissue regeneration. In this context, the application of electrical signals generated by piezoelectric materials in processes such as bone healing, nerve regeneration and skin repair has become a prospective strategy. By mimicking the natural bioelectrical environment, piezoelectric materials can stimulate cell proliferation, differentiation and connection, thereby accelerating the process of self-repair in the body. However, many challenges remain to be overcome before these concepts can be applied in clinical practice, including material selection, biocompatibility and equipment design. On the basis of the principle of electrical signal regulation, this article reviews the definition, mechanism of action, classification, preparation and current biomedical applications of piezoelectric materials and discusses opportunities and challenges for their future clinical translation.

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“…The use of nanogenerators (NG), in the way of piezoelectric nanostructures, for the stimulation of bone and muscle cells has been recently reported. [48,49] The electromechanical NG-cell interaction triggered the opening of ion channels present in the plasma membrane of osteoblast-like cells (Saos-2) and muscle cells inducing intracellular calcium transients, which at the same time is known to regulate muscle contraction. Poly(vinylidene fluoride) (PVDF) has also been explored for bone and neural tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Improved Performance of Biohybrid Muscle‐Based Bio‐Bots Doped with Piezoelectric Boron Nitride Nanotubes

Mestre

Fuentes

Lefaix

et al. 2022

Adv Materials Technologies

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their materials, such as compliance, flexibility, and overall safety for human interaction. Commonly, the rigidity and stiffness of conventional materials in robotics limit their applications into certain healthcare or biomedical disciplines. [1][2][3] Recent developments in material science have made possible the fabrication of biomimetic soft robots that are able to perform some simple types of actuation [4] including crawling, [5] gripping, [6] or change its shape, [7] but they are still far from the degree of complexity and movement sophistication in living organisms.One of the most investigated applications of soft robotics is the development of artificial muscles that can mimic the performance of native muscle tissue in mammals. Muscle tissue is inherently complex, being simultaneously strong and fast while enabling a wide variety of movements through an efficient self-organization of its fiber bundles. However, current materials still lack the ability to fully replicate these properties. [8] Even more, other features from biological tissues, such as self-healing, energy efficiency, power-to-weight ratio, adaptability or bio-sensing, to name only a few, are strongly desired but difficult to achieve with artificial soft materials. [9] Bio-hybrid robotics is born at this point as a synergistic strategy to integrate the best characteristics of biological entities and artificial materials into more efficient and complex systems, hoping to overcome the difficulties that current soft robots face. Several strategies to unify the development of bio-hybrid devices have Biohybrid robots, or bio-bots, integrate living and synthetic materials following a synergistic strategy to acquire some of the unique properties of biological organisms, like adaptability or bio-sensing, which are difficult to obtain exclusively using artificial materials. Skeletal muscle is one of the preferred candidates to power bio-bots, enabling a wide variety of movements from walking to swimming. Conductive nanocomposites, like gold nanoparticles or graphene, can provide benefits to muscle cells by improving the scaffolds' mechanical and conductive properties. Here, boron nitride nanotubes (BNNTs), with piezoelectric properties, are integrated in musclebased bio-bots and an improvement in their force output and motion speed is demonstrated. A full characterization of the BNNTs is provided, and their piezoelectric behavior with piezometer and dynamometer measurements is confirmed. It is hypothesized that the improved performance is a result of an electric field generated by the nanocomposites due to stresses produced by the cells during differentiation. This hypothesis is backed with finite element simulations supporting that this stress can generate a non-zero electric field within the matrix. With this work, it is shown that the integration of nanocomposite into muscle-based bio-bots can improve their performance, paving the way toward stronger and faster bio-hybrid robots.

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Biocompatibility and Electrical Stimulation of Skeletal and Smooth Muscle Cells Cultured on Piezoelectric Nanogenerators

Cited by 7 publications

References 36 publications

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration

Improved Performance of Biohybrid Muscle‐Based Bio‐Bots Doped with Piezoelectric Boron Nitride Nanotubes

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