Biocompatibility and Connectivity of Semiconductor Nanostructures for Cardiac Tissue Engineering Applications

Gaetani, Roberto; Derevyanchuk, Yuriy; Notargiacomo, Andrea; Pea, Marialilia; Renzi, Massimiliano; Messina, Elisa; Palma, F.

doi:10.3390/bioengineering9110621

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Generally, carbon-based nanomaterials like nanotubes, nanofibers and nanoparticles are known to be non-biodegradable which causes toxic effects in body tissues [31,32]. Gaetani et al studied the effects of ZnO nanowires on cardiac tissue and some degree of toxicity was confirmed [33]. ZnO nanostructures are known to produce reactive oxygen species (ROS) and release Zn 2+ ions which exert cytotoxic effects [34].…”

Section: Introductionmentioning

confidence: 99%

Investigation on the non-linear behaviour of silicon nanowires and assessment of the biosensing potential

Hakim

2023

Eng. Res. Express

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We perform a rigorous study on the conduction characteristics of long, low doped and relatively thick p-type silicon nanowire (SiNW) with different bias polarities/strengths to find out the origin of the non-linear electrical characteristics and to find out the applicable bias window for ensuring the gate responsive operation as biosensor. Depending on the polarity and strength of the drain bias (VDS)/liquid gate voltage (VGS), conduction is found to be confined in the bulk, in the surface accumulation region or in a path that comprises both accumulation region and the bulk thereby results in the diode or transistor like non-linear output characteristics. Although the SiNW is long without any junctions in the source/drain, the transfer characteristics exhibits a distinct shift with the increase of VDS when VDS is positive. The non-linear characteristics of SiNW is analysed to extract the gate responsive biasing window and it is found that the positive VDS application provides the flexibility of choosing diverse range of VDS and VGS voltages. As such, the shift in the transfer characteristic which is not appreciated for logic operation appears to be beneficiary for nanowire biosensors. This study sheds light on the variable electrical characteristics of SiNW reported in the literature and shows the way to choose appropriate bias conditions for biosensing applications.

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Section: Introductionmentioning

confidence: 99%

Investigation on the non-linear behaviour of silicon nanowires and assessment of the biosensing potential

Hakim

2023

Eng. Res. Express

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Cell spreading and viability on single-walled carbon nanotube/zinc oxide nanowire heterostructures synthesized by chemical vapor deposition

Luc,

Aziz,

Kim

et al. 2024

Front. Carbon

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Recent studies have shown the wide array of biomedical applications for nanomaterials such as single-walled carbon nanotubes (SWCNTs) and zinc oxide nanowires (ZnO NWs). SWCNTs are non-cytotoxic and have a varying range of mechanical, physical, and electrical properties useful to biomedical research. ZnO NWs are biocompatible, antibacterial, and exhibit piezoelectric properties that could stimulate cell growth. While recent research has been conducted using these nanomaterials independently, our study is focused on testing cell behaviors when seeded on SWCNTs, ZnO NWs and their heterostructure assemblies. ZnO NWs/SWCNTs heterostructures prepared via chemical vapor deposition (CVD) have not been used in biomedical applications to date. Here, we describe fabrication and characterization of the two nanomaterials independently and in a heterostructure formation. The NIH 3T3 fibroblast cells and U87 glioblastoma cells were seeded on all samples, including SiO2/Si control/reference samples, and the cell growth was studied via fluorescence microscopy and scanning electron microscopy. The focus of this study was to evaluate cell spreading, filopodia extensions, and cell viability on these nanomaterial assemblies. Results indicated that cells were able to extend filopodia on all nanostructures, however cell spreading was more pronounced on SWCNTs, and cell viability was compromised on the ZnO NWs and the ZnO NWs/SWCNTs heterostructures. In addition, soluble compounds from the nanomaterials were tested to determine their cytotoxicity towards both NIH 3T3 and U87 cells. Results indicated a significant decrease in filopodia length, cell spreading, and cell viability when cells were exposed to ZnO NWs-conditioned cell media. These findings on cellular behavior involving SWCNTs, ZnO NWs, and ZnO NWs/SWCNTs heterostructure provide valuable information on the suitability of SWCNTs and ZnO NWs for future uses in biomedical applications.

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Biocompatibility and Connectivity of Semiconductor Nanostructures for Cardiac Tissue Engineering Applications

Cited by 2 publications

References 55 publications

Investigation on the non-linear behaviour of silicon nanowires and assessment of the biosensing potential

Investigation on the non-linear behaviour of silicon nanowires and assessment of the biosensing potential

Cell spreading and viability on single-walled carbon nanotube/zinc oxide nanowire heterostructures synthesized by chemical vapor deposition

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