Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites

Page, Jonathan; Prieto, Edna M.; Dumas, Jerald E.; Zienkiewicz, Katarzyna J.; Wenke, Joseph C.; Baer, Pamela R. Brown; Guelcher, Scott A.

doi:10.1016/j.actbio.2012.07.037

Cited by 40 publications

(62 citation statements)

References 50 publications

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“…An index of 140 was chosen for the studies in this work to ensure complete crosslinking and a more rigid composite as reported previously. 8, 28, 35 …”

Section: Resultsmentioning

confidence: 99%

“…The isocyanate index (NCO:OH equivalent ratio * 100) was 140 for all materials. 8 TK diol, LTI-TK prepolymer, and 55 wt% MG or 60 wt% nHA particles were hand-mixed to yield a reactive paste. These concentrations of the ceramic particles were selected as the maximum values that could be added while maintaining a cohesive reactive paste.…”

Section: Methodsmentioning

confidence: 99%

“…8, 27 ATR-FTIR was used to evaluate the reaction rate of the isocyanate-terminated LTI-TK prepolymer with the other components of the composite individually by quantifying the disappearance of the isocyanate peak (around 2270 cm −1 ). The isocyanate peaks were calibrated to a standard curve of known NCO concentrations to find an initial rate constant for each reaction during the first 6 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…4, 5 Lysine-derived PEUR composites incorporating ceramic particles or allograft bone set in situ with no surgical complications and support bone remodeling in sheep, rats, and rabbits. 4–8 Previous work has shown lysine triisocyanate (LTI)-derived PEURs undergo autocatalytic hydrolytic degradation in which the acidic breakdown products accelerate resorption. 9, 10 A degradation mechanism that allows for a more controlled and predictable degradation rate is desired to ensure that the graft degrades at a rate complementary to bone formation and remodeling.…”

Section: Introductionmentioning

confidence: 99%

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Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

McEnery

Gupta

et al. 2016

RSC Adv.

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Synthetic bone cements are commonly used in orthopaedic procedures to aid in bone regeneration following trauma or disease. Polymeric cements like PMMA provide the mechanical strength necessary for orthopaedic applications, but they are not resorbable and do not integrate with host bone. Ceramic cements have a chemical composition similar to that of bone, but their brittle mechanical properties limit their use in weight-bearing applications. In this study, we designed oxidatively degradable, polymeric bone cements with mechanical properties suitable for bone tissue engineering applications. We synthesized a novel thioketal (TK) diol, which was crosslinked with a lysine triisocyanate (LTI) prepolymer to create hydrolytically stable poly(thioketal urethane)s (PTKUR) that degrade in the oxidative environment associated with bone defects. PTKUR films were hydrolytically stable for up to 6 months, but degraded rapidly (<1 week) under simulated oxidative conditions in vitro. When combined with ceramic micro- or nanoparticles, PTKUR cements exhibited working times comparable to calcium phosphate cements and strengths exceeding those of trabecular bone. PTKUR/ceramic composite cements supported appositional bone growth and integrated with host bone near the bone-cement interface at 6 and 12 weeks post-implantation in rabbit femoral condyle plug defects. Histological evidence of osteoclast-mediated resorption of the cements was observed at 6 and 12 weeks. These findings demonstrate that a PTKUR bone cement with bone-like strength can be selectively resorbed by cells involved in bone remodeling, and thus represent an important initial step toward the development of resorbable bone cements for weight-bearing applications.

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“…An index of 140 was chosen for the studies in this work to ensure complete crosslinking and a more rigid composite as reported previously. 8, 28, 35 …”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

McEnery

Gupta

et al. 2016

RSC Adv.

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“…The influence of the BG particle size on the dynamic rheological changes over time (viscosity, storage and loss moduli) was recently investigated [6][7][8]. The main efforts aimed at tailoring the compositions and the textural properties of BG-organic carriers in order to improve the biomineralisation kinetics, i.e., the deposition of a surface apatite layer [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles

et al. 2016

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Injectable bioglass (BG) pastes were produced using a melt-quenched glass based on CaO-MgO-SiO 2 -Na 2 O-P 2 O 5 -CaF 2 and two organic carriers, namely polyethylene glycol (PEG) and glycerol (Gly). The interactions between the organic carriers and the surface of the BG particles were assessed by spectroscopic methods (Fourier Transform Infrared, Raman, as well as 29Si and 13C solid-state NMR spectroscopy) in order to understand their effects on the viscoelastic properties of the biocomposites. While pure physical interactions were detected between PEG and the surface of the BG particles, chemical bonding was observed between glycerol and BG, enhancing the network cross-linking degree. Accordingly, the BG network of Gly-BG pastes was more condensed (higher fraction of Q [3] units detected by Raman spectroscopy) in comparison to that of PEG-BG and bare BG. Such chemical interactions between the organic carrier and BG were shown to negatively affect the viscoelastic behaviour of the resulting pastes. Thus, the PEG-based biocomposite exhibited improved flowability in comparison to its analogous Gly-BG biocomposite.

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Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth

Waugh

Cosgrove

Hussain

et al. 2019

Advances in Contact Angle, Wettability and Adhesion

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Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites

Cited by 40 publications

References 50 publications

Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles

Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth

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