Biocompatibility and Biological Corrosion Resistance of Ti–39Nb–6Zr+0.45Al Implant Alloy

Hwang, Yujin; Choi, Young-Sin; Hwang, Yunho; Cho, Hyunwook; Lee, Dong‐Geun

doi:10.3390/jfb12010002

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…The key to determining the implantation status depends on the interaction between the biomaterial and host tissue. Unfortunately, conventional biomaterials have related issues in guiding tissues for implantation at specific sites and influencing cellular functions, e.g., metals have greater stiffness and elastic modulus than physiological bone, leading to stress shielding [ 169 ], whereas bioceramics lack ductility and fracture toughness [ 170 ]. In addition, polymeric materials suffer from progressive wear and temperature-dependent deformation under loading conditions [ 171 ].…”

Section: Nano-medicine In Bone Repairmentioning

confidence: 99%

The advances in nanomedicine for bone and cartilage repair

Qiao

Tang

et al. 2022

J Nanobiotechnol

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With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimulate the necessary cellular response to promote sufficient cartilage regeneration, bone remodeling and osseointegration. In recent years, the rapid development of nanomedicine has initiated a revolution in orthopedics, especially in tissue engineering and regenerative medicine, due to their capacity to effectively stimulate cellular responses on a nanoscale with enhanced drug loading efficiency, targeted capability, increased mechanical properties and improved uptake rate, resulting in an improved therapeutic effect. Therefore, a comprehensive review of advancements in nanomedicine for bone and cartilage diseases is timely and beneficial. This review firstly summarized the wide range of existing nanotechnology applications in the medical field. The progressive development of nano delivery systems in nanomedicine, including nanoparticles and biomimetic techniques, which are lacking in the current literature, is further described. More importantly, we also highlighted the research advancements of nanomedicine in bone and cartilage repair using the latest preclinical and clinical examples, and further discussed the research directions of nano-therapies in future clinical practice. Graphical Abstract

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Section: Nano-medicine In Bone Repairmentioning

confidence: 99%

The advances in nanomedicine for bone and cartilage repair

Qiao

Tang

et al. 2022

J Nanobiotechnol

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show abstract

“…Biocompatibility has shown to be dependent on the interrelation of various factors influencing the bulk and surface properties of biomaterials, which include surface topography (e.g., surface roughness), surface chemistry (e.g., surface tension and purity for wetting), and nature of tissue integration (e.g., fibrous, osseous, or mixed) [ 146 – 148 ].…”

Section: Surface Modifications Of Titaniummentioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of α, β, and α + β. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. Graphic abstract

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“…The oxidized coating adheres strongly to the tissue and is insoluble and chemically impermeable, which prevents it from reacting with the surrounding environment [ 48 ]. The biological neutrality of titanium is used in surgery in the form of implants, i.e., spinal implants, dental implants and knee or hip endoprostheses [ 49 , 50 ]. Recent developments in β-type Ti-based alloys for biomedical applications have been provided by Chen et al [ 51 ].…”

Section: Incremental Sheet Forming Towards Biomedical Applicationsmentioning

confidence: 99%

Single-Point Incremental Forming of Titanium and Titanium Alloy Sheets

et al. 2021

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Incremental sheet forming of titanium and its alloys has a significant role in modern manufacturing techniques because it allows for the production of high-quality products with complex shapes at low production costs. Stamping processes are a major contributor to plastic working techniques in industries such as automotive, aerospace and medicine. This article reviews the development of the single-point incremental forming (SPIF) technique in titanium and its alloys. Problems of a tribological and microstructural nature that make it difficult to obtain components with the desired geometric and shape accuracy are discussed. Great emphasis is placed on current trends in SPIF of difficult-to-form α-, α + β- and β-type titanium alloys. Potential uses of SPIF for forming products in various industries are also indicated, with a particular focus on medical applications. The conclusions of the review provide a structured guideline for scientists and practitioners working on incremental forming of titanium and titanium alloy sheets. One of the ways to increase the formability and minimize the springback of titanium alloys is to treat them at elevated temperatures. The main approaches developed for introducing temperature into a workpiece are friction heating, electrical heating and laser heating. The selection of an appropriate lubricant is a key aspect of the forming process of titanium and its alloys, which exhibit unfavorable tribological properties such as high adhesion and a tendency to adhesive wear. A review of the literature showed that there are insufficient investigations into the synergistic effect of rotational speed and tool rotation direction on the surface roughness of workpieces.

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Biocompatibility and Biological Corrosion Resistance of Ti–39Nb–6Zr+0.45Al Implant Alloy

Cited by 20 publications

References 27 publications

The advances in nanomedicine for bone and cartilage repair

The advances in nanomedicine for bone and cartilage repair

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Single-Point Incremental Forming of Titanium and Titanium Alloy Sheets

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